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With its source in Minnesota, it is joined by the Missouri at Saint Louis and by the Ohio at [Cairo, Illinois]? -- it drains most of the are between the Rocky Mountains and the [Appalachian Mountains]?, except for the area drained by the Great Lakes.
It runs through, or borders, a number of states in the United States, including Minnesota, Iowa, Illinois, Missouri, Tennessee, Mississippi, and Louisiana? before emptying into the [Gulf of Mexico]? a small distance downstream from New Orleans.