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Wikipedia: Heraclitus of Ephesus
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Heraclitus of Ephesus disagreed with Thales, Anaximander, and Pythagoras about the nature of the ultimate substance. Claiming instead that everything was derived from fire, rather than air, water, or earth. This lead to the belief that change was real, and stability illusory. For Heraclitus of Ephesus "everything is in flux?."
He is famous for saying "No man can cross the same river twice, because nether the man, nor the river are the same."
Hericlitus' view that an explanation of change was foundational to any theory of nature was, of course, strongly opposed by Parmenides who argued that change is an illusion and everything is fundamentally static.