Wikipedia
gpewiki
https://gpe.wikipedia.org/wiki/Main_Page
MediaWiki 1.47.0-wmf.2
first-letter
Media
Special
Talk
User
User talk
Wikipedia
Wikipedia talk
File
File talk
MediaWiki
MediaWiki talk
Template
Template talk
Help
Help talk
Category
Category talk
TimedText
TimedText talk
Module
Module talk
Event
Event talk
Permethrin
0
26902
98180
2026-05-17T14:00:04Z
DaSupremo
9
Created by translating the page [[:mdwiki:Special:Redirect/revision/1469123|Permethrin]] to:gpe #mdwikicx
98180
wikitext
text/x-wiki
[[Category:Translated from MDWiki]]
r0gf7axtnvt68k0p85plnlehx64o08u
98181
98180
2026-05-17T14:04:27Z
DaSupremo
9
Improve article
98181
wikitext
text/x-wiki
{{Databox}}
'''Permethrin''' be a medication den an insecticide.<ref name=AHFS2016 /><ref name=Key2013>{{cite book | vauthors = Keystone JS, Kozarsky PE, Freedman DO, Connor BA | date = 2013 | title = Travel Medicine | publisher = Elsevier Health Sciences | page = 58 | isbn = 978-1-4557-1076-8 | url = https://books.google.com/books?id=hSf30j2YFSMC&pg=PA58 | archive-date = 20 December 2016 | archive-url = https://web.archive.org/web/20161220155051/https://books.google.ca/books?id=hSf30j2YFSMC&pg=PA58 | url-status = live }}</ref> As a medication, e be used to treat [[scabies]] den lice.<ref name=WHO2008>{{cite book | year = 2009 | veditors = Stuart MC, Kouimtzi M, Hill SR | title = WHO Model Formulary 2008 | publisher = [[World Health Organization]] | page = 213 | isbn = 978-92-4-154765-9 | hdl = 10665/44053 }}</ref> E be applied to de skin as a cream anaa lotion.<ref name=AHFS2016>{{cite web|title=Permethrin|url=https://www.drugs.com/monograph/permethrin.html|publisher=The American Society of Health-System Pharmacists|access-date=8 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161221013040/https://www.drugs.com/monograph/permethrin.html|archive-date=21 December 2016}}</ref> As an insecticide, e fi be sprayed onto outer clothing anaa mosquito nets to kill de insects wey touch dem.<ref name=Key2013 /><ref name="usepa">{{cite web |title=Repellent-Treated Clothing |date=15 July 2013 |url=https://www.epa.gov/insect-repellents/repellent-treated-clothing |publisher=United States Environmental Protection Agency |access-date=28 May 2023}}</ref>
== References ==
[[Category:Translated from MDWiki]]
67ai9oz3brdjwvlhstgas2qtrggsrzh
98182
98181
2026-05-17T14:08:47Z
DaSupremo
9
Improve article
98182
wikitext
text/x-wiki
{{Databox}}
'''Permethrin''' be a medication den an insecticide.<ref name=AHFS2016 /><ref name=Key2013>{{cite book | vauthors = Keystone JS, Kozarsky PE, Freedman DO, Connor BA | date = 2013 | title = Travel Medicine | publisher = Elsevier Health Sciences | page = 58 | isbn = 978-1-4557-1076-8 | url = https://books.google.com/books?id=hSf30j2YFSMC&pg=PA58 | archive-date = 20 December 2016 | archive-url = https://web.archive.org/web/20161220155051/https://books.google.ca/books?id=hSf30j2YFSMC&pg=PA58 | url-status = live }}</ref> As a medication, e be used to treat [[scabies]] den lice.<ref name=WHO2008>{{cite book | year = 2009 | veditors = Stuart MC, Kouimtzi M, Hill SR | title = WHO Model Formulary 2008 | publisher = [[World Health Organization]] | page = 213 | isbn = 978-92-4-154765-9 | hdl = 10665/44053 }}</ref> E be applied to de skin as a cream anaa lotion.<ref name=AHFS2016>{{cite web|title=Permethrin|url=https://www.drugs.com/monograph/permethrin.html|publisher=The American Society of Health-System Pharmacists|access-date=8 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161221013040/https://www.drugs.com/monograph/permethrin.html|archive-date=21 December 2016}}</ref> As an insecticide, e fi be sprayed onto outer clothing anaa mosquito nets to kill de insects wey touch dem.<ref name=Key2013 /><ref name="usepa">{{cite web |title=Repellent-Treated Clothing |date=15 July 2013 |url=https://www.epa.gov/insect-repellents/repellent-treated-clothing |publisher=United States Environmental Protection Agency |access-date=28 May 2023}}</ref>
Side effects dey include rash den irritation wer e be applied.<ref name=WHO2008 /> Use during [[pregnancy]] dey appear to be safe, wey e be approved for use on den around people over de age of two months insyd de [[United States]].<ref name=AHFS2016 /> Permethrin dey insyd de pyrethroid family of medications.<ref name=AHFS2016 /> E dey work by disrupting de function of de neurons of arthropods such as lice, mites,<ref name=AHFS2016 /> insects, den shrimp, wey dey make am highly toxic to dese animals. E sanso be highly toxic to fish.<ref name="RED2">{{cite web |author=Environmental Protection Agency |author-link=United States Environmental Protection Agency |date=June 2006 |title=Permethrin Facts (Reregistration Eligibility Decision (RED) Fact Sheet) |url=https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-109701_1-Jun-06.pdf |url-status=live |archive-url=https://web.archive.org/web/20200806094905/https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-109701_1-Jun-06.pdf |archive-date=6 August 2020 |access-date=13 May 2020 |website=epa.gov |publisher=EPA Special Review and Reregistration Division}}</ref> E be of low toxicity to birds den mammals. However, cats be more sensitive to am dan oda mammals secof much slower metabolism.<ref name="PermGen2">{{cite web |title=Permethrin General Fact Sheet |url=http://npic.orst.edu/factsheets/PermGen.html#wildlife |archive-url=https://web.archive.org/web/20180103154911/http://npic.orst.edu/factsheets/PermGen.html#wildlife |archive-date=3 January 2018 |access-date=6 January 2018 |website=npic.orst.edu}}</ref>
== References ==
[[Category:Translated from MDWiki]]
<references />
== External links ==
79kpxfocan07kjw6rwlu9wpjyatjqsn
98183
98182
2026-05-17T14:11:14Z
DaSupremo
9
Improve article
98183
wikitext
text/x-wiki
{{Databox}}
'''Permethrin''' be a medication den an insecticide.<ref name=AHFS2016 /><ref name=Key2013>{{cite book | vauthors = Keystone JS, Kozarsky PE, Freedman DO, Connor BA | date = 2013 | title = Travel Medicine | publisher = Elsevier Health Sciences | page = 58 | isbn = 978-1-4557-1076-8 | url = https://books.google.com/books?id=hSf30j2YFSMC&pg=PA58 | archive-date = 20 December 2016 | archive-url = https://web.archive.org/web/20161220155051/https://books.google.ca/books?id=hSf30j2YFSMC&pg=PA58 | url-status = live }}</ref> As a medication, e be used to treat [[scabies]] den lice.<ref name=WHO2008>{{cite book | year = 2009 | veditors = Stuart MC, Kouimtzi M, Hill SR | title = WHO Model Formulary 2008 | publisher = [[World Health Organization]] | page = 213 | isbn = 978-92-4-154765-9 | hdl = 10665/44053 }}</ref> E be applied to de skin as a cream anaa lotion.<ref name=AHFS2016>{{cite web|title=Permethrin|url=https://www.drugs.com/monograph/permethrin.html|publisher=The American Society of Health-System Pharmacists|access-date=8 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161221013040/https://www.drugs.com/monograph/permethrin.html|archive-date=21 December 2016}}</ref> As an insecticide, e fi be sprayed onto outer clothing anaa mosquito nets to kill de insects wey touch dem.<ref name=Key2013 /><ref name="usepa">{{cite web |title=Repellent-Treated Clothing |date=15 July 2013 |url=https://www.epa.gov/insect-repellents/repellent-treated-clothing |publisher=United States Environmental Protection Agency |access-date=28 May 2023}}</ref>
Side effects dey include rash den irritation wer e be applied.<ref name=WHO2008 /> Use during [[pregnancy]] dey appear to be safe, wey e be approved for use on den around people over de age of two months insyd de [[United States]].<ref name=AHFS2016 /> Permethrin dey insyd de pyrethroid family of medications.<ref name=AHFS2016 /> E dey work by disrupting de function of de neurons of arthropods such as lice, mites,<ref name=AHFS2016 /> insects, den shrimp, wey dey make am highly toxic to dese animals. E sanso be highly toxic to fish.<ref name="RED2">{{cite web |author=Environmental Protection Agency |author-link=United States Environmental Protection Agency |date=June 2006 |title=Permethrin Facts (Reregistration Eligibility Decision (RED) Fact Sheet) |url=https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-109701_1-Jun-06.pdf |url-status=live |archive-url=https://web.archive.org/web/20200806094905/https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-109701_1-Jun-06.pdf |archive-date=6 August 2020 |access-date=13 May 2020 |website=epa.gov |publisher=EPA Special Review and Reregistration Division}}</ref> E be of low toxicity to birds den mammals. However, cats be more sensitive to am dan oda mammals secof much slower metabolism.<ref name="PermGen2">{{cite web |title=Permethrin General Fact Sheet |url=http://npic.orst.edu/factsheets/PermGen.html#wildlife |archive-url=https://web.archive.org/web/20180103154911/http://npic.orst.edu/factsheets/PermGen.html#wildlife |archive-date=3 January 2018 |access-date=6 January 2018 |website=npic.orst.edu}}</ref>
Na dem discover permethrin insyd 1972.<ref name=":02">{{cite journal |vauthors=Elliott M, Farnham AW, Janes NF, Needham PH, Pulman DA, Stevenson JH |date=November 1973 |title=A photostable pyrethroid |journal=Nature |volume=246 |issue=5429 |pages=169–170 |bibcode=1973Natur.246..169E |doi=10.1038/246169a0 |pmid=4586114 |s2cid=4176154}}</ref> E be on de World Health Organization's List of Essential Medicines.<ref name="WHO23rd">{{cite book | year = 2023 | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | publisher = [[World Health Organization]] | hdl = 10665/371090 | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access = free }}</ref> Insyd 2022, na e be de 351st most commonly prescribed medication insyd de United States, plus more dan 40,000 prescriptions.<ref>{{cite web | title = Permethrin Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Permethrin | access-date = 30 August 2024 }}</ref>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
j21qwzx4lmretwj90050c0bk4igvrhr
98184
98183
2026-05-17T14:16:12Z
DaSupremo
9
/* External links */ Improve article
98184
wikitext
text/x-wiki
{{Databox}}
'''Permethrin''' be a medication den an insecticide.<ref name=AHFS2016 /><ref name=Key2013>{{cite book | vauthors = Keystone JS, Kozarsky PE, Freedman DO, Connor BA | date = 2013 | title = Travel Medicine | publisher = Elsevier Health Sciences | page = 58 | isbn = 978-1-4557-1076-8 | url = https://books.google.com/books?id=hSf30j2YFSMC&pg=PA58 | archive-date = 20 December 2016 | archive-url = https://web.archive.org/web/20161220155051/https://books.google.ca/books?id=hSf30j2YFSMC&pg=PA58 | url-status = live }}</ref> As a medication, e be used to treat [[scabies]] den lice.<ref name=WHO2008>{{cite book | year = 2009 | veditors = Stuart MC, Kouimtzi M, Hill SR | title = WHO Model Formulary 2008 | publisher = [[World Health Organization]] | page = 213 | isbn = 978-92-4-154765-9 | hdl = 10665/44053 }}</ref> E be applied to de skin as a cream anaa lotion.<ref name=AHFS2016>{{cite web|title=Permethrin|url=https://www.drugs.com/monograph/permethrin.html|publisher=The American Society of Health-System Pharmacists|access-date=8 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161221013040/https://www.drugs.com/monograph/permethrin.html|archive-date=21 December 2016}}</ref> As an insecticide, e fi be sprayed onto outer clothing anaa mosquito nets to kill de insects wey touch dem.<ref name=Key2013 /><ref name="usepa">{{cite web |title=Repellent-Treated Clothing |date=15 July 2013 |url=https://www.epa.gov/insect-repellents/repellent-treated-clothing |publisher=United States Environmental Protection Agency |access-date=28 May 2023}}</ref>
Side effects dey include rash den irritation wer e be applied.<ref name=WHO2008 /> Use during [[pregnancy]] dey appear to be safe, wey e be approved for use on den around people over de age of two months insyd de [[United States]].<ref name=AHFS2016 /> Permethrin dey insyd de pyrethroid family of medications.<ref name=AHFS2016 /> E dey work by disrupting de function of de neurons of arthropods such as lice, mites,<ref name=AHFS2016 /> insects, den shrimp, wey dey make am highly toxic to dese animals. E sanso be highly toxic to fish.<ref name="RED2">{{cite web |author=Environmental Protection Agency |author-link=United States Environmental Protection Agency |date=June 2006 |title=Permethrin Facts (Reregistration Eligibility Decision (RED) Fact Sheet) |url=https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-109701_1-Jun-06.pdf |url-status=live |archive-url=https://web.archive.org/web/20200806094905/https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-109701_1-Jun-06.pdf |archive-date=6 August 2020 |access-date=13 May 2020 |website=epa.gov |publisher=EPA Special Review and Reregistration Division}}</ref> E be of low toxicity to birds den mammals. However, cats be more sensitive to am dan oda mammals secof much slower metabolism.<ref name="PermGen2">{{cite web |title=Permethrin General Fact Sheet |url=http://npic.orst.edu/factsheets/PermGen.html#wildlife |archive-url=https://web.archive.org/web/20180103154911/http://npic.orst.edu/factsheets/PermGen.html#wildlife |archive-date=3 January 2018 |access-date=6 January 2018 |website=npic.orst.edu}}</ref>
Na dem discover permethrin insyd 1972.<ref name=":02">{{cite journal |vauthors=Elliott M, Farnham AW, Janes NF, Needham PH, Pulman DA, Stevenson JH |date=November 1973 |title=A photostable pyrethroid |journal=Nature |volume=246 |issue=5429 |pages=169–170 |bibcode=1973Natur.246..169E |doi=10.1038/246169a0 |pmid=4586114 |s2cid=4176154}}</ref> E be on de World Health Organization's List of Essential Medicines.<ref name="WHO23rd">{{cite book | year = 2023 | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | publisher = [[World Health Organization]] | hdl = 10665/371090 | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access = free }}</ref> Insyd 2022, na e be de 351st most commonly prescribed medication insyd de United States, plus more dan 40,000 prescriptions.<ref>{{cite web | title = Permethrin Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Permethrin | access-date = 30 August 2024 }}</ref>
== References ==
<references />
== External links ==
{{Commons}}
* ''[http://sitem.herts.ac.uk/aeru/ppdb/en/Reports/515.htm Permethrin]'' in the Pesticide Properties DataBase (PPDB)
* [https://npic.orst.edu/factsheets/PermGen.pdf Permethrin General Fact Sheet] National Pesticide Information Center
** [https://npic.orst.edu/factsheets/archive/Permtech.html Permethrin Technical Fact Sheet] National Pesticide Information Center
** [https://npic.orst.edu/pest/mosquito/ptc.html Permethrin-treated Clothing] National Pesticide Information Center
* [https://nap.nationalacademies.org/catalog/9274/health-effects-of-permethrin-impregnated-army-battle-dress-uniforms "Health Effects of Permethrin-Impregnated Army Battle-Dress Uniforms"] National Research Council
* [https://extoxnet.orst.edu/pips/permethr.htm Permethrin Pesticide Information Profile] Extension Toxicology Network
[[Category:Translated from MDWiki]]
sxi3bfyxmway7mendyixtr666gklbsc
98185
98184
2026-05-17T14:17:08Z
DaSupremo
9
Add categories
98185
wikitext
text/x-wiki
{{Databox}}
'''Permethrin''' be a medication den an insecticide.<ref name=AHFS2016 /><ref name=Key2013>{{cite book | vauthors = Keystone JS, Kozarsky PE, Freedman DO, Connor BA | date = 2013 | title = Travel Medicine | publisher = Elsevier Health Sciences | page = 58 | isbn = 978-1-4557-1076-8 | url = https://books.google.com/books?id=hSf30j2YFSMC&pg=PA58 | archive-date = 20 December 2016 | archive-url = https://web.archive.org/web/20161220155051/https://books.google.ca/books?id=hSf30j2YFSMC&pg=PA58 | url-status = live }}</ref> As a medication, e be used to treat [[scabies]] den lice.<ref name=WHO2008>{{cite book | year = 2009 | veditors = Stuart MC, Kouimtzi M, Hill SR | title = WHO Model Formulary 2008 | publisher = [[World Health Organization]] | page = 213 | isbn = 978-92-4-154765-9 | hdl = 10665/44053 }}</ref> E be applied to de skin as a cream anaa lotion.<ref name=AHFS2016>{{cite web|title=Permethrin|url=https://www.drugs.com/monograph/permethrin.html|publisher=The American Society of Health-System Pharmacists|access-date=8 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161221013040/https://www.drugs.com/monograph/permethrin.html|archive-date=21 December 2016}}</ref> As an insecticide, e fi be sprayed onto outer clothing anaa mosquito nets to kill de insects wey touch dem.<ref name=Key2013 /><ref name="usepa">{{cite web |title=Repellent-Treated Clothing |date=15 July 2013 |url=https://www.epa.gov/insect-repellents/repellent-treated-clothing |publisher=United States Environmental Protection Agency |access-date=28 May 2023}}</ref>
Side effects dey include rash den irritation wer e be applied.<ref name=WHO2008 /> Use during [[pregnancy]] dey appear to be safe, wey e be approved for use on den around people over de age of two months insyd de [[United States]].<ref name=AHFS2016 /> Permethrin dey insyd de pyrethroid family of medications.<ref name=AHFS2016 /> E dey work by disrupting de function of de neurons of arthropods such as lice, mites,<ref name=AHFS2016 /> insects, den shrimp, wey dey make am highly toxic to dese animals. E sanso be highly toxic to fish.<ref name="RED2">{{cite web |author=Environmental Protection Agency |author-link=United States Environmental Protection Agency |date=June 2006 |title=Permethrin Facts (Reregistration Eligibility Decision (RED) Fact Sheet) |url=https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-109701_1-Jun-06.pdf |url-status=live |archive-url=https://web.archive.org/web/20200806094905/https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_PC-109701_1-Jun-06.pdf |archive-date=6 August 2020 |access-date=13 May 2020 |website=epa.gov |publisher=EPA Special Review and Reregistration Division}}</ref> E be of low toxicity to birds den mammals. However, cats be more sensitive to am dan oda mammals secof much slower metabolism.<ref name="PermGen2">{{cite web |title=Permethrin General Fact Sheet |url=http://npic.orst.edu/factsheets/PermGen.html#wildlife |archive-url=https://web.archive.org/web/20180103154911/http://npic.orst.edu/factsheets/PermGen.html#wildlife |archive-date=3 January 2018 |access-date=6 January 2018 |website=npic.orst.edu}}</ref>
Na dem discover permethrin insyd 1972.<ref name=":02">{{cite journal |vauthors=Elliott M, Farnham AW, Janes NF, Needham PH, Pulman DA, Stevenson JH |date=November 1973 |title=A photostable pyrethroid |journal=Nature |volume=246 |issue=5429 |pages=169–170 |bibcode=1973Natur.246..169E |doi=10.1038/246169a0 |pmid=4586114 |s2cid=4176154}}</ref> E be on de World Health Organization's List of Essential Medicines.<ref name="WHO23rd">{{cite book | year = 2023 | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | publisher = [[World Health Organization]] | hdl = 10665/371090 | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access = free }}</ref> Insyd 2022, na e be de 351st most commonly prescribed medication insyd de United States, plus more dan 40,000 prescriptions.<ref>{{cite web | title = Permethrin Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Permethrin | access-date = 30 August 2024 }}</ref>
== References ==
<references />
== External links ==
{{Commons}}
* ''[http://sitem.herts.ac.uk/aeru/ppdb/en/Reports/515.htm Permethrin]'' in the Pesticide Properties DataBase (PPDB)
* [https://npic.orst.edu/factsheets/PermGen.pdf Permethrin General Fact Sheet] National Pesticide Information Center
** [https://npic.orst.edu/factsheets/archive/Permtech.html Permethrin Technical Fact Sheet] National Pesticide Information Center
** [https://npic.orst.edu/pest/mosquito/ptc.html Permethrin-treated Clothing] National Pesticide Information Center
* [https://nap.nationalacademies.org/catalog/9274/health-effects-of-permethrin-impregnated-army-battle-dress-uniforms "Health Effects of Permethrin-Impregnated Army Battle-Dress Uniforms"] National Research Council
* [https://extoxnet.orst.edu/pips/permethr.htm Permethrin Pesticide Information Profile] Extension Toxicology Network
[[Category:Antiparasitic agents]]
[[Category:Household chemicals]]
[[Category:Organochlorides]]
[[Category:Endocrine disruptors]]
[[Category:(3-phenoxyphenyl)methyl 2,2,3-trimethylcyclopropane-1-carboxylates]]
[[Category:Acaricides]]
[[Category:Over-the-counter drugs insyd de United States]]
[[Category:World Health Organization essential medicines]]
[[Category:Translated from MDWiki]]
kl55vk043gyssjvl44yyuq932lyqajw
Category:Household chemicals
14
26903
98186
2026-05-17T14:17:54Z
DaSupremo
9
Fresh category
98186
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:Organochlorides
14
26904
98187
2026-05-17T14:18:04Z
DaSupremo
9
Fresh category
98187
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:Endocrine disruptors
14
26905
98188
2026-05-17T14:18:15Z
DaSupremo
9
Fresh category
98188
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:(3-phenoxyphenyl)methyl 2,2,3-trimethylcyclopropane-1-carboxylates
14
26906
98189
2026-05-17T14:18:25Z
DaSupremo
9
Fresh category
98189
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Famotidine
0
26907
98190
2026-05-17T14:19:41Z
DaSupremo
9
Created by translating the page [[:mdwiki:Special:Redirect/revision/1456953|Famotidine]] to:gpe #mdwikicx
98190
wikitext
text/x-wiki
[[Category:Translated from MDWiki]]
r0gf7axtnvt68k0p85plnlehx64o08u
98191
98190
2026-05-17T14:27:05Z
DaSupremo
9
Improve article
98191
wikitext
text/x-wiki
{{Databox}}
'''Famotidine''', dem sell under de brand name '''Pepcid''' among odas, be a histamine H<sub>2</sub> receptor antagonist medication wey dey decrease stomach acid production.<ref name="AHFS2019">{{cite web |title=Famotidine Monograph for Professionals |url=https://www.drugs.com/monograph/famotidine.html |access-date=3 March 2019 |website=Drugs.com |publisher=American Society of Health-System Pharmacists |archive-date=17 June 2019 |archive-url=https://web.archive.org/web/20190617034316/https://www.drugs.com/monograph/famotidine.html |url-status=live }}</ref> E be used to treat peptic ulcer disease, [[gastroesophageal reflux disease]], den Zollinger–Ellison syndrome.<ref name=AHFS2019/> Dem dey take am by mouth anaa by injection into a vein.<ref name=AHFS2019/> E dey begin dey work within an hour.<ref name=AHFS2019/>
== References ==
[[Category:Translated from MDWiki]]
<references />
== External links ==
fpknenxnutkybaq2g7jtaefh4m2u3tu
98192
98191
2026-05-17T14:30:53Z
DaSupremo
9
Improve article
98192
wikitext
text/x-wiki
{{Databox}}
'''Famotidine''', dem sell under de brand name '''Pepcid''' among odas, be a histamine H<sub>2</sub> receptor antagonist medication wey dey decrease stomach acid production.<ref name="AHFS2019">{{cite web |title=Famotidine Monograph for Professionals |url=https://www.drugs.com/monograph/famotidine.html |access-date=3 March 2019 |website=Drugs.com |publisher=American Society of Health-System Pharmacists |archive-date=17 June 2019 |archive-url=https://web.archive.org/web/20190617034316/https://www.drugs.com/monograph/famotidine.html |url-status=live }}</ref> E be used to treat peptic ulcer disease, [[gastroesophageal reflux disease]], den Zollinger–Ellison syndrome.<ref name=AHFS2019/> Dem dey take am by mouth anaa by injection into a vein.<ref name=AHFS2019/> E dey begin dey work within an hour.<ref name=AHFS2019/>
Common side effects dey include headache, abdominal pain, [[diarrhea]] anaa constipation, den dizziness.<ref name=AHFS2019/> Serious side effects fi include [[pneumonia]] den seizures.<ref name=AHFS2019/><ref name="BNF762">{{cite book |title=British national formulary : BNF 76 |date=2018 |publisher=Pharmaceutical Press |isbn=9780857113382 |edition=76 |pages=74–75}}</ref> Ein use insyd [[pregnancy]] dey appear safe buh e no be well studied, while use during [[breastfeeding]] no be recommended.<ref name=Preg2019>{{cite web |title=Famotidine Pregnancy and Breastfeeding Warnings |url=https://www.drugs.com/pregnancy/famotidine.html |website=Drugs.com |access-date=3 March 2019 |archive-date=16 December 2023 |archive-url=https://web.archive.org/web/20231216171826/https://www.drugs.com/pregnancy/famotidine.html |url-status=live }}</ref>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
5i64w5n29pze2m5k5am2ghgzzqu4gs5
98193
98192
2026-05-17T14:33:08Z
DaSupremo
9
Improve article
98193
wikitext
text/x-wiki
{{Databox}}
'''Famotidine''', dem sell under de brand name '''Pepcid''' among odas, be a histamine H<sub>2</sub> receptor antagonist medication wey dey decrease stomach acid production.<ref name="AHFS2019">{{cite web |title=Famotidine Monograph for Professionals |url=https://www.drugs.com/monograph/famotidine.html |access-date=3 March 2019 |website=Drugs.com |publisher=American Society of Health-System Pharmacists |archive-date=17 June 2019 |archive-url=https://web.archive.org/web/20190617034316/https://www.drugs.com/monograph/famotidine.html |url-status=live }}</ref> E be used to treat peptic ulcer disease, [[gastroesophageal reflux disease]], den Zollinger–Ellison syndrome.<ref name=AHFS2019/> Dem dey take am by mouth anaa by injection into a vein.<ref name=AHFS2019/> E dey begin dey work within an hour.<ref name=AHFS2019/>
Common side effects dey include headache, abdominal pain, [[diarrhea]] anaa constipation, den dizziness.<ref name=AHFS2019/> Serious side effects fi include [[pneumonia]] den seizures.<ref name=AHFS2019/><ref name="BNF762">{{cite book |title=British national formulary : BNF 76 |date=2018 |publisher=Pharmaceutical Press |isbn=9780857113382 |edition=76 |pages=74–75}}</ref> Ein use insyd [[pregnancy]] dey appear safe buh e no be well studied, while use during [[breastfeeding]] no be recommended.<ref name=Preg2019>{{cite web |title=Famotidine Pregnancy and Breastfeeding Warnings |url=https://www.drugs.com/pregnancy/famotidine.html |website=Drugs.com |access-date=3 March 2019 |archive-date=16 December 2023 |archive-url=https://web.archive.org/web/20231216171826/https://www.drugs.com/pregnancy/famotidine.html |url-status=live }}</ref>
Dem patent famotidine insyd 1979 wey e cam into medical use insyd 1985.<ref name="Fischer-2006">{{cite book |vauthors=Fischer J, Ganellin CR |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=444 |url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA444 |access-date=7 May 2020 |archive-date=29 July 2020 |archive-url=https://web.archive.org/web/20200729131140/https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA444 |url-status=live }}</ref> E be available as a generic medication.<ref name=BNF76>{{cite book|title=British national formulary : BNF 76|date=2018|publisher=Pharmaceutical Press|isbn=9780857113382|pages=74–75|edition=76}}</ref> Insyd 2023, na e be de 33rd most commonly prescribed medication insyd de [[United States]], plus more dan 16{{nbsp}}million prescriptions.<ref name="Top300Drugs">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Famotidine Drug Usage Statistics, United States, 2014 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Famotidine | access-date = 17 August 2025 }}</ref>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
mfy2c88fvjfmw24novbm9yyhz2cvak8
98194
98193
2026-05-17T14:35:28Z
DaSupremo
9
Improve article
98194
wikitext
text/x-wiki
{{Databox}}
'''Famotidine''', dem sell under de brand name '''Pepcid''' among odas, be a histamine H<sub>2</sub> receptor antagonist medication wey dey decrease stomach acid production.<ref name="AHFS2019">{{cite web |title=Famotidine Monograph for Professionals |url=https://www.drugs.com/monograph/famotidine.html |access-date=3 March 2019 |website=Drugs.com |publisher=American Society of Health-System Pharmacists |archive-date=17 June 2019 |archive-url=https://web.archive.org/web/20190617034316/https://www.drugs.com/monograph/famotidine.html |url-status=live }}</ref> E be used to treat peptic ulcer disease, [[gastroesophageal reflux disease]], den Zollinger–Ellison syndrome.<ref name=AHFS2019/> Dem dey take am by mouth anaa by injection into a vein.<ref name=AHFS2019/> E dey begin dey work within an hour.<ref name=AHFS2019/>
Common side effects dey include headache, abdominal pain, [[diarrhea]] anaa constipation, den dizziness.<ref name=AHFS2019/> Serious side effects fi include [[pneumonia]] den seizures.<ref name=AHFS2019/><ref name="BNF762">{{cite book |title=British national formulary : BNF 76 |date=2018 |publisher=Pharmaceutical Press |isbn=9780857113382 |edition=76 |pages=74–75}}</ref> Ein use insyd [[pregnancy]] dey appear safe buh e no be well studied, while use during [[breastfeeding]] no be recommended.<ref name=Preg2019>{{cite web |title=Famotidine Pregnancy and Breastfeeding Warnings |url=https://www.drugs.com/pregnancy/famotidine.html |website=Drugs.com |access-date=3 March 2019 |archive-date=16 December 2023 |archive-url=https://web.archive.org/web/20231216171826/https://www.drugs.com/pregnancy/famotidine.html |url-status=live }}</ref>
Dem patent famotidine insyd 1979 wey e cam into medical use insyd 1985.<ref name="Fischer-2006">{{cite book |vauthors=Fischer J, Ganellin CR |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=444 |url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA444 |access-date=7 May 2020 |archive-date=29 July 2020 |archive-url=https://web.archive.org/web/20200729131140/https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA444 |url-status=live }}</ref> E be available as a generic medication.<ref name=BNF76>{{cite book|title=British national formulary : BNF 76|date=2018|publisher=Pharmaceutical Press|isbn=9780857113382|pages=74–75|edition=76}}</ref> Insyd 2023, na e be de 33rd most commonly prescribed medication insyd de [[United States]], plus more dan 16{{nbsp}}million prescriptions.<ref name="Top300Drugs">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Famotidine Drug Usage Statistics, United States, 2014 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Famotidine | access-date = 17 August 2025 }}</ref>
== References ==
<references />
== External links ==
{{Commons}}
[[Category:Amidines]]
[[Category:Guanidines]]
[[Category:H2 receptor antagonists]]
[[Category:Sulfamides]]
[[Category:Thiazoles]]
[[Category:Thioethers]]
[[Category:Over-the-counter drugs insyd de United States]]
[[Category:Antihistamines]]
[[Category:Translated from MDWiki]]
2ha0tf8vlg11yvqcrbjw8xyxujy40ee
Category:Sulfamides
14
26908
98195
2026-05-17T14:36:01Z
DaSupremo
9
Fresh category
98195
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:Thioethers
14
26909
98196
2026-05-17T14:36:12Z
DaSupremo
9
Fresh category
98196
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Haloperidol
0
26910
98197
2026-05-17T14:42:17Z
DaSupremo
9
Created by translating the page [[:mdwiki:Special:Redirect/revision/1458267|Haloperidol]] to:gpe #mdwikicx
98197
wikitext
text/x-wiki
[[Category:Translated from MDWiki]]
r0gf7axtnvt68k0p85plnlehx64o08u
98198
98197
2026-05-17T14:57:00Z
DaSupremo
9
Improve article
98198
wikitext
text/x-wiki
{{Databox}}
'''Haloperidol''', dem sell under de brand name '''Haldol''' among odas, be a typical antipsychotic medication.<ref name="AHFS20152">{{cite web |title=Haloperidol |url=https://www.drugs.com/monograph/haloperidol.html |url-status=live |archive-url=https://web.archive.org/web/20150102120426/http://www.drugs.com/monograph/haloperidol.html |archive-date=2 January 2015 |access-date=2 January 2015 |publisher=The American Society of Health-System Pharmacists}}</ref> Haloperidol be used insyd de treatment of [[schizophrenia]], tics insyd [[Tourette syndrome]], [[mania]] insyd [[bipolar disorder]], [[delirium]], agitation, acute [[psychosis]], den hallucinations from alcohol withdrawal.<ref name="AHFS20152" /><ref name= NEJM2014>{{cite journal | vauthors = Schuckit MA | title = Recognition and management of withdrawal delirium (delirium tremens) | journal = The New England Journal of Medicine | volume = 371 | issue = 22 | pages = 2109–2113 | date = November 2014 | pmid = 25427113 | doi = 10.1056/NEJMra1407298 | s2cid = 205116954 | url = https://escholarship.org/uc/item/08b9z9th }}</ref><ref>{{cite journal | vauthors = Plosker GL | title = Quetiapine: a pharmacoeconomic review of its use in bipolar disorder | journal = PharmacoEconomics | volume = 30 | issue = 7 | pages = 611–631 | date = July 2012 | pmid = 22559293 | doi = 10.2165/11208500-000000000-00000 }}</ref> E fi be used by mouth anaa injection into a muscle anaa a vein.<ref name="AHFS20152" /> Haloperidol typically dey work within 30 to 60 minutes.<ref name="AHFS20152" /> A long-acting formulation fi be used as an injection every four weeks for people plus schizophrenia anaa related illnesses, wey either forget anaa refuse to take de medication by mouth.<ref name="AHFS20152" />
== References ==
[[Category:Translated from MDWiki]]
<references />
== External links ==
l14fxco8slwrtdtrd5u3lluwrwpwo49
98199
98198
2026-05-17T15:02:38Z
DaSupremo
9
Improve article
98199
wikitext
text/x-wiki
{{Databox}}
'''Haloperidol''', dem sell under de brand name '''Haldol''' among odas, be a typical antipsychotic medication.<ref name="AHFS20152">{{cite web |title=Haloperidol |url=https://www.drugs.com/monograph/haloperidol.html |url-status=live |archive-url=https://web.archive.org/web/20150102120426/http://www.drugs.com/monograph/haloperidol.html |archive-date=2 January 2015 |access-date=2 January 2015 |publisher=The American Society of Health-System Pharmacists}}</ref> Haloperidol be used insyd de treatment of [[schizophrenia]], tics insyd [[Tourette syndrome]], [[mania]] insyd [[bipolar disorder]], [[delirium]], agitation, acute [[psychosis]], den hallucinations from alcohol withdrawal.<ref name="AHFS20152" /><ref name= NEJM2014>{{cite journal | vauthors = Schuckit MA | title = Recognition and management of withdrawal delirium (delirium tremens) | journal = The New England Journal of Medicine | volume = 371 | issue = 22 | pages = 2109–2113 | date = November 2014 | pmid = 25427113 | doi = 10.1056/NEJMra1407298 | s2cid = 205116954 | url = https://escholarship.org/uc/item/08b9z9th }}</ref><ref>{{cite journal | vauthors = Plosker GL | title = Quetiapine: a pharmacoeconomic review of its use in bipolar disorder | journal = PharmacoEconomics | volume = 30 | issue = 7 | pages = 611–631 | date = July 2012 | pmid = 22559293 | doi = 10.2165/11208500-000000000-00000 }}</ref> E fi be used by mouth anaa injection into a muscle anaa a vein.<ref name="AHFS20152" /> Haloperidol typically dey work within 30 to 60 minutes.<ref name="AHFS20152" /> A long-acting formulation fi be used as an injection every four weeks for people plus schizophrenia anaa related illnesses, wey either forget anaa refuse to take de medication by mouth.<ref name="AHFS20152" />
Haloperidol fi result in movement disorders such as tardive dyskinesia, den [[akathisia]], both of wich fi be permanent.<ref name=AHFS2015 /> Neuroleptic malignant syndrome den QT interval prolongation fi occur, de latter particularly plus IV administration.<ref name=AHFS2015 /> Insyd older people plus psychosis secof [[dementia]] e dey result in an increased risk of death.<ref name= AHFS2015>{{cite web |title = Haloperidol |url = https://www.drugs.com/monograph/haloperidol.html |publisher = The American Society of Health-System Pharmacists |access-date = 2 January 2015 |url-status = live |archive-url = https://web.archive.org/web/20150102120426/http://www.drugs.com/monograph/haloperidol.html |archive-date = 2 January 2015 }}</ref> Wen dem take am during pregnancy e fi result in problems insyd de infant.<ref name=AHFS2015 /><ref name=TGA2015>{{cite web |title = Prescribing medicines in pregnancy database |url = http://www.tga.gov.au/hp/medicines-pregnancy.htm |work = Australian Government |access-date = 2 January 2015 |date = 3 March 2014 |url-status = live |archive-url = https://web.archive.org/web/20140408040902/http://www.tga.gov.au/hp/medicines-pregnancy.htm |archive-date = 8 April 2014 }}</ref> E for no be be used by people plus [[Parkinson's disease]].<ref name=AHFS2015 />
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
b7o0ibsm62z7ms58tk1aqb3ijms98fr
98200
98199
2026-05-17T15:06:06Z
DaSupremo
9
Improve article
98200
wikitext
text/x-wiki
{{Databox}}
'''Haloperidol''', dem sell under de brand name '''Haldol''' among odas, be a typical antipsychotic medication.<ref name="AHFS20152">{{cite web |title=Haloperidol |url=https://www.drugs.com/monograph/haloperidol.html |url-status=live |archive-url=https://web.archive.org/web/20150102120426/http://www.drugs.com/monograph/haloperidol.html |archive-date=2 January 2015 |access-date=2 January 2015 |publisher=The American Society of Health-System Pharmacists}}</ref> Haloperidol be used insyd de treatment of [[schizophrenia]], tics insyd [[Tourette syndrome]], [[mania]] insyd [[bipolar disorder]], [[delirium]], agitation, acute [[psychosis]], den hallucinations from alcohol withdrawal.<ref name="AHFS20152" /><ref name= NEJM2014>{{cite journal | vauthors = Schuckit MA | title = Recognition and management of withdrawal delirium (delirium tremens) | journal = The New England Journal of Medicine | volume = 371 | issue = 22 | pages = 2109–2113 | date = November 2014 | pmid = 25427113 | doi = 10.1056/NEJMra1407298 | s2cid = 205116954 | url = https://escholarship.org/uc/item/08b9z9th }}</ref><ref>{{cite journal | vauthors = Plosker GL | title = Quetiapine: a pharmacoeconomic review of its use in bipolar disorder | journal = PharmacoEconomics | volume = 30 | issue = 7 | pages = 611–631 | date = July 2012 | pmid = 22559293 | doi = 10.2165/11208500-000000000-00000 }}</ref> E fi be used by mouth anaa injection into a muscle anaa a vein.<ref name="AHFS20152" /> Haloperidol typically dey work within 30 to 60 minutes.<ref name="AHFS20152" /> A long-acting formulation fi be used as an injection every four weeks for people plus schizophrenia anaa related illnesses, wey either forget anaa refuse to take de medication by mouth.<ref name="AHFS20152" />
Haloperidol fi result in movement disorders such as tardive dyskinesia, den [[akathisia]], both of wich fi be permanent.<ref name=AHFS2015 /> Neuroleptic malignant syndrome den QT interval prolongation fi occur, de latter particularly plus IV administration.<ref name=AHFS2015 /> Insyd older people plus psychosis secof [[dementia]] e dey result in an increased risk of death.<ref name= AHFS2015>{{cite web |title = Haloperidol |url = https://www.drugs.com/monograph/haloperidol.html |publisher = The American Society of Health-System Pharmacists |access-date = 2 January 2015 |url-status = live |archive-url = https://web.archive.org/web/20150102120426/http://www.drugs.com/monograph/haloperidol.html |archive-date = 2 January 2015 }}</ref> Wen dem take am during pregnancy e fi result in problems insyd de infant.<ref name=AHFS2015 /><ref name=TGA2015>{{cite web |title = Prescribing medicines in pregnancy database |url = http://www.tga.gov.au/hp/medicines-pregnancy.htm |work = Australian Government |access-date = 2 January 2015 |date = 3 March 2014 |url-status = live |archive-url = https://web.archive.org/web/20140408040902/http://www.tga.gov.au/hp/medicines-pregnancy.htm |archive-date = 8 April 2014 }}</ref> E for no be be used by people plus [[Parkinson's disease]].<ref name=AHFS2015 />
Na dem discover haloperidol insyd 1958 by de team of Paul Janssen,<ref>{{cite book | vauthors = Sneader W |title = Drug discovery: a history |date = 2005 |publisher = Wiley |location = Chichester |isbn = 978-0-471-89979-2 |page = 124 |edition = Rev. and updated |url = https://books.google.com/books?id=Cb6BOkj9fK4C&pg=PA124 |url-status = live |archive-url = https://web.archive.org/web/20151208072014/https://books.google.ca/books?id=Cb6BOkj9fK4C&pg=PA124 |archive-date = 8 December 2015 }}</ref> dem prepare as part of a structure-activity relationship investigation into analogs of pethidine (meperidine).<ref>{{cite book | vauthors = Ravina E |title = The evolution of drug discovery: from traditional medicines to modern drugs |date = 2011 |publisher = Wiley-VCH |location = Weinheim |isbn = 978-3-527-32669-3 |page = 62 |edition = 1. Aufl. |url = https://books.google.com/books?id=iDNy0XxGqT8C&pg=PA62 |url-status = live |archive-url = https://web.archive.org/web/20151208071857/https://books.google.ca/books?id=iDNy0XxGqT8C&pg=PA62 |archive-date = 8 December 2015 }}</ref> E dey on de World Health Organization's List of Essential Medicines.<ref name="WHO22nd">{{cite book | title = World Health Organization model list of essential medicines: 22nd list (2021) | year = 2021 | hdl = 10665/345533 | publisher = [[World Health Organization]] | location = Geneva | id = WHO/MHP/HPS/EML/2021.02 | hdl-access=free }}</ref> E be de most commonly used typical antipsychotic.<ref name=Ste2004>{{cite book | vauthors = Stevens A |title = Health care needs assessment: the epidemiologically based needs assessment reviews |date = 2004 |publisher = Radcliffe Medical |location = Abingdon |isbn = 978-1-85775-892-4 |page = 202 |edition = 2nd |url = https://books.google.com/books?id=HCLIeMG9WgoC&pg=PA202 |url-status = live |archive-url = https://web.archive.org/web/20151208072515/https://books.google.ca/books?id=HCLIeMG9WgoC&pg=PA202 |archive-date = 8 December 2015 }}</ref> Insyd 2020, na e be de 303rd most commonly prescribed medication insyd de [[United States]], plus more dan 1{{nbsp}}million prescriptions.<ref>{{cite web | title = Haloperidol - Drug Usage Statistics | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Haloperidol | access-date = 7 October 2022}}</ref>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
hnq9y9fv8r8ifsyxkyqjdlsg0rvw17u
98201
98200
2026-05-17T15:10:37Z
DaSupremo
9
Improve article
98201
wikitext
text/x-wiki
{{Databox}}
'''Haloperidol''', dem sell under de brand name '''Haldol''' among odas, be a typical antipsychotic medication.<ref name="AHFS20152">{{cite web |title=Haloperidol |url=https://www.drugs.com/monograph/haloperidol.html |url-status=live |archive-url=https://web.archive.org/web/20150102120426/http://www.drugs.com/monograph/haloperidol.html |archive-date=2 January 2015 |access-date=2 January 2015 |publisher=The American Society of Health-System Pharmacists}}</ref> Haloperidol be used insyd de treatment of [[schizophrenia]], tics insyd [[Tourette syndrome]], [[mania]] insyd [[bipolar disorder]], [[delirium]], agitation, acute [[psychosis]], den hallucinations from alcohol withdrawal.<ref name="AHFS20152" /><ref name= NEJM2014>{{cite journal | vauthors = Schuckit MA | title = Recognition and management of withdrawal delirium (delirium tremens) | journal = The New England Journal of Medicine | volume = 371 | issue = 22 | pages = 2109–2113 | date = November 2014 | pmid = 25427113 | doi = 10.1056/NEJMra1407298 | s2cid = 205116954 | url = https://escholarship.org/uc/item/08b9z9th }}</ref><ref>{{cite journal | vauthors = Plosker GL | title = Quetiapine: a pharmacoeconomic review of its use in bipolar disorder | journal = PharmacoEconomics | volume = 30 | issue = 7 | pages = 611–631 | date = July 2012 | pmid = 22559293 | doi = 10.2165/11208500-000000000-00000 }}</ref> E fi be used by mouth anaa injection into a muscle anaa a vein.<ref name="AHFS20152" /> Haloperidol typically dey work within 30 to 60 minutes.<ref name="AHFS20152" /> A long-acting formulation fi be used as an injection every four weeks for people plus schizophrenia anaa related illnesses, wey either forget anaa refuse to take de medication by mouth.<ref name="AHFS20152" />
Haloperidol fi result in movement disorders such as tardive dyskinesia, den [[akathisia]], both of wich fi be permanent.<ref name=AHFS2015 /> Neuroleptic malignant syndrome den QT interval prolongation fi occur, de latter particularly plus IV administration.<ref name=AHFS2015 /> Insyd older people plus psychosis secof [[dementia]] e dey result in an increased risk of death.<ref name= AHFS2015>{{cite web |title = Haloperidol |url = https://www.drugs.com/monograph/haloperidol.html |publisher = The American Society of Health-System Pharmacists |access-date = 2 January 2015 |url-status = live |archive-url = https://web.archive.org/web/20150102120426/http://www.drugs.com/monograph/haloperidol.html |archive-date = 2 January 2015 }}</ref> Wen dem take am during pregnancy e fi result in problems insyd de infant.<ref name=AHFS2015 /><ref name=TGA2015>{{cite web |title = Prescribing medicines in pregnancy database |url = http://www.tga.gov.au/hp/medicines-pregnancy.htm |work = Australian Government |access-date = 2 January 2015 |date = 3 March 2014 |url-status = live |archive-url = https://web.archive.org/web/20140408040902/http://www.tga.gov.au/hp/medicines-pregnancy.htm |archive-date = 8 April 2014 }}</ref> E for no be be used by people plus [[Parkinson's disease]].<ref name=AHFS2015 />
Na dem discover haloperidol insyd 1958 by de team of Paul Janssen,<ref>{{cite book | vauthors = Sneader W |title = Drug discovery: a history |date = 2005 |publisher = Wiley |location = Chichester |isbn = 978-0-471-89979-2 |page = 124 |edition = Rev. and updated |url = https://books.google.com/books?id=Cb6BOkj9fK4C&pg=PA124 |url-status = live |archive-url = https://web.archive.org/web/20151208072014/https://books.google.ca/books?id=Cb6BOkj9fK4C&pg=PA124 |archive-date = 8 December 2015 }}</ref> dem prepare as part of a structure-activity relationship investigation into analogs of pethidine (meperidine).<ref>{{cite book | vauthors = Ravina E |title = The evolution of drug discovery: from traditional medicines to modern drugs |date = 2011 |publisher = Wiley-VCH |location = Weinheim |isbn = 978-3-527-32669-3 |page = 62 |edition = 1. Aufl. |url = https://books.google.com/books?id=iDNy0XxGqT8C&pg=PA62 |url-status = live |archive-url = https://web.archive.org/web/20151208071857/https://books.google.ca/books?id=iDNy0XxGqT8C&pg=PA62 |archive-date = 8 December 2015 }}</ref> E dey on de World Health Organization's List of Essential Medicines.<ref name="WHO22nd">{{cite book | title = World Health Organization model list of essential medicines: 22nd list (2021) | year = 2021 | hdl = 10665/345533 | publisher = [[World Health Organization]] | location = Geneva | id = WHO/MHP/HPS/EML/2021.02 | hdl-access=free }}</ref> E be de most commonly used typical antipsychotic.<ref name=Ste2004>{{cite book | vauthors = Stevens A |title = Health care needs assessment: the epidemiologically based needs assessment reviews |date = 2004 |publisher = Radcliffe Medical |location = Abingdon |isbn = 978-1-85775-892-4 |page = 202 |edition = 2nd |url = https://books.google.com/books?id=HCLIeMG9WgoC&pg=PA202 |url-status = live |archive-url = https://web.archive.org/web/20151208072515/https://books.google.ca/books?id=HCLIeMG9WgoC&pg=PA202 |archive-date = 8 December 2015 }}</ref> Insyd 2020, na e be de 303rd most commonly prescribed medication insyd de [[United States]], plus more dan 1{{nbsp}}million prescriptions.<ref>{{cite web | title = Haloperidol - Drug Usage Statistics | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Haloperidol | access-date = 7 October 2022}}</ref>
== References ==
<references />
== External links ==
{{Commons}}
[[Category:4-Chlorophenyl compounds]]
[[Category:4-Fluorophenyl compounds]]
[[Category:4-Phenylpiperidines]]
[[Category:Antiaggressive drugs]]
[[Category:Antiemetics]]
[[Category:Belgian inventions]]
[[Category:Butyrophenone antipsychotics]]
[[Category:Chemical substances for emergency medicine]]
[[Category:CYP2D6 inducers]]
[[Category:CYP2D6 inhibitors]]
[[Category:Drugs wey Johnson & Johnson develop]]
[[Category:HERG blocker]]
[[Category:Janssen Pharmaceutica]]
[[Category:Monoaminergic neurotoxins]]
[[Category:NMDA receptor antagonists]]
[[Category:Prolactin releasers]]
[[Category:Suspected embryotoxicants]]
[[Category:Suspected fetotoxicants]]
[[Category:Tertiary alcohols]]
[[Category:Typical antipsychotics]]
[[Category:World Health Organization essential medicines]]
[[Category:Translated from MDWiki]]
93eo4dr0qiyrfq326ghcj7tow99e77i
Category:4-Chlorophenyl compounds
14
26911
98202
2026-05-17T15:11:27Z
DaSupremo
9
Fresh category
98202
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:4-Phenylpiperidines
14
26912
98203
2026-05-17T15:11:37Z
DaSupremo
9
Fresh category
98203
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:Butyrophenone antipsychotics
14
26913
98204
2026-05-17T15:11:47Z
DaSupremo
9
Fresh category
98204
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:CYP2D6 inducers
14
26914
98205
2026-05-17T15:12:12Z
DaSupremo
9
Fresh category
98205
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:Monoaminergic neurotoxins
14
26915
98206
2026-05-17T15:12:42Z
DaSupremo
9
Fresh category
98206
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:Suspected embryotoxicants
14
26916
98207
2026-05-17T15:12:54Z
DaSupremo
9
Fresh category
98207
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:Suspected fetotoxicants
14
26917
98208
2026-05-17T15:13:06Z
DaSupremo
9
Fresh category
98208
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:Typical antipsychotics
14
26918
98209
2026-05-17T15:13:19Z
DaSupremo
9
Fresh category
98209
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Paroxetine
0
26919
98210
2026-05-17T15:14:33Z
DaSupremo
9
Created by translating the page [[:mdwiki:Special:Redirect/revision/1468981|Paroxetine]] to:gpe #mdwikicx
98210
wikitext
text/x-wiki
[[Category:Translated from MDWiki]]
r0gf7axtnvt68k0p85plnlehx64o08u
98211
98210
2026-05-17T15:22:26Z
DaSupremo
9
Improve article
98211
wikitext
text/x-wiki
{{Databox}}
'''Paroxetine''', dem sell under de brand name '''Paxil''' among odas, be an antidepressant medication of de [[selective serotonin reuptake inhibitor]] (SSRI) class<ref name=AHFS2019>{{cite web|url=https://www.drugs.com/monograph/paroxetine-hydrochloride.html|title=Paroxetine Hydrochloride Monograph for Professionals|website=Drugs.com|publisher=American Society of Health-System Pharmacists|access-date=3 March 2019|archive-url=https://web.archive.org/web/20190306043802/https://www.drugs.com/monograph/paroxetine-hydrochloride.html|archive-date=6 March 2019|url-status=live}}</ref> dem use to treat [[major depressive disorder]], obsessive–compulsive disorder (OCD), [[panic disorder]], [[social anxiety disorder]], [[post-traumatic stress disorder]] (PTSD), [[generalized anxiety disorder]], den premenstrual dysphoric disorder.<ref name=AHFS2019/> E sanso be used insyd de treatment of premature ejaculation,<ref name=":22">{{cite journal |vauthors=Raisi F, Soleimani R, Ahmadzadeh A, Sadati SN, Fakhrian A, Jalali MM |date=June 2025 |title=Efficacy and safety of pharmacological treatments in patients with premature ejaculation: an umbrella review of meta-analyses of randomized controlled trials |journal=The Journal of Sexual Medicine |volume=22 |issue=6 |pages=1014–1023 |doi=10.1093/jsxmed/qdaf094 |pmid=40326158}}</ref> den hot flashes secof [[menopause]].<ref name=AHFS2019/><ref name=FDA2013>{{cite press release|title=FDA approves the first non-hormonal treatment for hot flashes associated with menopause| vauthors = Fischer A |publisher=Food and Drug Administration|date=28 June 2013|url=https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm359030.htm|archive-url=https://web.archive.org/web/20170118091242/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm359030.htm |archive-date=18 January 2017}}</ref> Dem dey take am orally (by mouth).<ref name=AHFS2019/>
== References ==
[[Category:Translated from MDWiki]]
<references />
== External links ==
dvi7xcfke5ke05eij97fvy3r7vevifg
98212
98211
2026-05-17T15:50:44Z
DaSupremo
9
Improve article
98212
wikitext
text/x-wiki
{{Databox}}
'''Paroxetine''', dem sell under de brand name '''Paxil''' among odas, be an antidepressant medication of de [[selective serotonin reuptake inhibitor]] (SSRI) class<ref name=AHFS2019>{{cite web|url=https://www.drugs.com/monograph/paroxetine-hydrochloride.html|title=Paroxetine Hydrochloride Monograph for Professionals|website=Drugs.com|publisher=American Society of Health-System Pharmacists|access-date=3 March 2019|archive-url=https://web.archive.org/web/20190306043802/https://www.drugs.com/monograph/paroxetine-hydrochloride.html|archive-date=6 March 2019|url-status=live}}</ref> dem use to treat [[major depressive disorder]], obsessive–compulsive disorder (OCD), [[panic disorder]], [[social anxiety disorder]], [[post-traumatic stress disorder]] (PTSD), [[generalized anxiety disorder]], den premenstrual dysphoric disorder.<ref name=AHFS2019/> E sanso be used insyd de treatment of premature ejaculation,<ref name=":22">{{cite journal |vauthors=Raisi F, Soleimani R, Ahmadzadeh A, Sadati SN, Fakhrian A, Jalali MM |date=June 2025 |title=Efficacy and safety of pharmacological treatments in patients with premature ejaculation: an umbrella review of meta-analyses of randomized controlled trials |journal=The Journal of Sexual Medicine |volume=22 |issue=6 |pages=1014–1023 |doi=10.1093/jsxmed/qdaf094 |pmid=40326158}}</ref> den hot flashes secof [[menopause]].<ref name=AHFS2019/><ref name=FDA2013>{{cite press release|title=FDA approves the first non-hormonal treatment for hot flashes associated with menopause| vauthors = Fischer A |publisher=Food and Drug Administration|date=28 June 2013|url=https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm359030.htm|archive-url=https://web.archive.org/web/20170118091242/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm359030.htm |archive-date=18 January 2017}}</ref> Dem dey take am orally (by mouth).<ref name=AHFS2019/>
Common side effects dey include drowsiness, dry mouth, loss of appetite, sweating, [[insomnia|trouble sleeping]], den sexual dysfunction.<ref name="AHFS2019" /> Insyd sam patients, sexual dysfunction fi persist even after de drug be discontinued, a condition dem know as post-SSRI sexual dysfunction; regulatory agencies wey dey include de European Medicines Agency den Health Canada recommend say paroxetine ein product labeling warn of dis risk.<ref name="Healy2022">{{cite journal |vauthors=Healy D, Bahrick A, Bak M, Barbato A, Calabro RS, Chubak BM |date=2022 |title=Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin |journal=International Journal of Risk & Safety in Medicine |volume=33 |issue=1 |pages=65–76 |doi=10.3233/JRS-210023 |pmc=8925105 |pmid=34719438}}</ref><ref name="PRAC2019">{{cite web |date=11 June 2019 |title=PRAC recommendations on signals adopted at the 13-16 May 2019 PRAC meeting |url=https://www.ema.europa.eu/en/documents/prac-recommendation/prac-recommendations-signals-adopted-13-16-may-2019-prac-meeting_en.pdf |access-date=8 April 2026 |publisher=European Medicines Agency}}</ref> Serious side effects fi include suicidal thoughts insyd those under de age of 25, [[serotonin syndrome]], den [[mania]].<ref name=AHFS2019/>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
3ckgu753cub3jrw32xfgmiuay12ejld
98213
98212
2026-05-17T15:54:37Z
DaSupremo
9
Improve article
98213
wikitext
text/x-wiki
{{Databox}}
'''Paroxetine''', dem sell under de brand name '''Paxil''' among odas, be an antidepressant medication of de [[selective serotonin reuptake inhibitor]] (SSRI) class<ref name=AHFS2019>{{cite web|url=https://www.drugs.com/monograph/paroxetine-hydrochloride.html|title=Paroxetine Hydrochloride Monograph for Professionals|website=Drugs.com|publisher=American Society of Health-System Pharmacists|access-date=3 March 2019|archive-url=https://web.archive.org/web/20190306043802/https://www.drugs.com/monograph/paroxetine-hydrochloride.html|archive-date=6 March 2019|url-status=live}}</ref> dem use to treat [[major depressive disorder]], obsessive–compulsive disorder (OCD), [[panic disorder]], [[social anxiety disorder]], [[post-traumatic stress disorder]] (PTSD), [[generalized anxiety disorder]], den premenstrual dysphoric disorder.<ref name=AHFS2019/> E sanso be used insyd de treatment of premature ejaculation,<ref name=":22">{{cite journal |vauthors=Raisi F, Soleimani R, Ahmadzadeh A, Sadati SN, Fakhrian A, Jalali MM |date=June 2025 |title=Efficacy and safety of pharmacological treatments in patients with premature ejaculation: an umbrella review of meta-analyses of randomized controlled trials |journal=The Journal of Sexual Medicine |volume=22 |issue=6 |pages=1014–1023 |doi=10.1093/jsxmed/qdaf094 |pmid=40326158}}</ref> den hot flashes secof [[menopause]].<ref name=AHFS2019/><ref name=FDA2013>{{cite press release|title=FDA approves the first non-hormonal treatment for hot flashes associated with menopause| vauthors = Fischer A |publisher=Food and Drug Administration|date=28 June 2013|url=https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm359030.htm|archive-url=https://web.archive.org/web/20170118091242/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm359030.htm |archive-date=18 January 2017}}</ref> Dem dey take am orally (by mouth).<ref name=AHFS2019/>
Common side effects dey include drowsiness, dry mouth, loss of appetite, sweating, [[insomnia|trouble sleeping]], den sexual dysfunction.<ref name="AHFS2019" /> Insyd sam patients, sexual dysfunction fi persist even after de drug be discontinued, a condition dem know as post-SSRI sexual dysfunction; regulatory agencies wey dey include de European Medicines Agency den Health Canada recommend say paroxetine ein product labeling warn of dis risk.<ref name="Healy2022">{{cite journal |vauthors=Healy D, Bahrick A, Bak M, Barbato A, Calabro RS, Chubak BM |date=2022 |title=Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin |journal=International Journal of Risk & Safety in Medicine |volume=33 |issue=1 |pages=65–76 |doi=10.3233/JRS-210023 |pmc=8925105 |pmid=34719438}}</ref><ref name="PRAC2019">{{cite web |date=11 June 2019 |title=PRAC recommendations on signals adopted at the 13-16 May 2019 PRAC meeting |url=https://www.ema.europa.eu/en/documents/prac-recommendation/prac-recommendations-signals-adopted-13-16-may-2019-prac-meeting_en.pdf |access-date=8 April 2026 |publisher=European Medicines Agency}}</ref> Serious side effects fi include suicidal thoughts insyd those under de age of 25, [[serotonin syndrome]], den [[mania]].<ref name=AHFS2019/>
Dem approve paroxetine for medical use insyd de [[United States]] insyd 1992 wey initially e be sold by GlaxoSmithKline.<ref name=AHFS2019/><ref>{{cite book |author=Food and Drug Administration |title=Approved Drug Products with Therapeutic Equivalence Evaluations – FDA Orange Book 31st Edition (2011): FDA Orange Book 31st Edition (2011) |date=2011 |publisher=DrugPatentWatch.com |isbn=978-1-934899-81-6 |page=344 |url=https://books.google.com/books?id=JDZ4DAAAQBAJ&pg=PR344 |access-date=4 March 2019 |archive-url=https://web.archive.org/web/20190306043352/https://books.google.ca/books?id=JDZ4DAAAQBAJ&pg=PR344 |archive-date=6 March 2019 |url-status=live}}</ref> E dey on de World Health Organization's List of Essential Medicines.<ref name="WHO23rd">{{cite book | vauthors = ((World Health Organization)) | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref> E be available as a generic medication.<ref name=BNF76>{{cite book|title=British national formulary: BNF 76 |date=2018 |publisher=Pharmaceutical Press |isbn=978-0-85711-338-2|pages=363|edition=76}}</ref> Insyd 2023, na e be de 72nd most commonly prescribed medication insyd de United States, plus more dan 9{{nbsp}}million prescriptions.<ref name="Top300Drugs">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref name="ClinCalc Paroxetine">{{cite web | title = Paroxetine Drug Usage Statistics, United States, 2013 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Paroxetine | access-date = 18 August 2025 }}</ref> Insyd 2018, na e dey insyd de top 10 of most prescribed antidepressants insyd de United States.<ref>{{Cite web |vauthors=Grohol JM |date=15 December 2019 |title=Top 25 Psychiatric Medications for 2018 |url=https://psychcentral.com/blog/top-25-psychiatric-medications-for-2018/ |access-date=26 September 2020 |website=psychcentral.com |archive-date=25 October 2020 |archive-url=https://web.archive.org/web/20201025001611/https://psychcentral.com/blog/top-25-psychiatric-medications-for-2018/ |url-status=live }}</ref>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
fd3w1awpfdnnb9a0vyc8jm17h09y2zr
98214
98213
2026-05-17T15:56:52Z
DaSupremo
9
Improve article
98214
wikitext
text/x-wiki
{{Databox}}
'''Paroxetine''', dem sell under de brand name '''Paxil''' among odas, be an antidepressant medication of de [[selective serotonin reuptake inhibitor]] (SSRI) class<ref name=AHFS2019>{{cite web|url=https://www.drugs.com/monograph/paroxetine-hydrochloride.html|title=Paroxetine Hydrochloride Monograph for Professionals|website=Drugs.com|publisher=American Society of Health-System Pharmacists|access-date=3 March 2019|archive-url=https://web.archive.org/web/20190306043802/https://www.drugs.com/monograph/paroxetine-hydrochloride.html|archive-date=6 March 2019|url-status=live}}</ref> dem use to treat [[major depressive disorder]], obsessive–compulsive disorder (OCD), [[panic disorder]], [[social anxiety disorder]], [[post-traumatic stress disorder]] (PTSD), [[generalized anxiety disorder]], den premenstrual dysphoric disorder.<ref name=AHFS2019/> E sanso be used insyd de treatment of premature ejaculation,<ref name=":22">{{cite journal |vauthors=Raisi F, Soleimani R, Ahmadzadeh A, Sadati SN, Fakhrian A, Jalali MM |date=June 2025 |title=Efficacy and safety of pharmacological treatments in patients with premature ejaculation: an umbrella review of meta-analyses of randomized controlled trials |journal=The Journal of Sexual Medicine |volume=22 |issue=6 |pages=1014–1023 |doi=10.1093/jsxmed/qdaf094 |pmid=40326158}}</ref> den hot flashes secof [[menopause]].<ref name=AHFS2019/><ref name=FDA2013>{{cite press release|title=FDA approves the first non-hormonal treatment for hot flashes associated with menopause| vauthors = Fischer A |publisher=Food and Drug Administration|date=28 June 2013|url=https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm359030.htm|archive-url=https://web.archive.org/web/20170118091242/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm359030.htm |archive-date=18 January 2017}}</ref> Dem dey take am orally (by mouth).<ref name=AHFS2019/>
Common side effects dey include drowsiness, dry mouth, loss of appetite, sweating, [[insomnia|trouble sleeping]], den sexual dysfunction.<ref name="AHFS2019" /> Insyd sam patients, sexual dysfunction fi persist even after de drug be discontinued, a condition dem know as post-SSRI sexual dysfunction; regulatory agencies wey dey include de European Medicines Agency den Health Canada recommend say paroxetine ein product labeling warn of dis risk.<ref name="Healy2022">{{cite journal |vauthors=Healy D, Bahrick A, Bak M, Barbato A, Calabro RS, Chubak BM |date=2022 |title=Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin |journal=International Journal of Risk & Safety in Medicine |volume=33 |issue=1 |pages=65–76 |doi=10.3233/JRS-210023 |pmc=8925105 |pmid=34719438}}</ref><ref name="PRAC2019">{{cite web |date=11 June 2019 |title=PRAC recommendations on signals adopted at the 13-16 May 2019 PRAC meeting |url=https://www.ema.europa.eu/en/documents/prac-recommendation/prac-recommendations-signals-adopted-13-16-may-2019-prac-meeting_en.pdf |access-date=8 April 2026 |publisher=European Medicines Agency}}</ref> Serious side effects fi include suicidal thoughts insyd those under de age of 25, [[serotonin syndrome]], den [[mania]].<ref name=AHFS2019/>
Dem approve paroxetine for medical use insyd de [[United States]] insyd 1992 wey initially e be sold by GlaxoSmithKline.<ref name=AHFS2019/><ref>{{cite book |author=Food and Drug Administration |title=Approved Drug Products with Therapeutic Equivalence Evaluations – FDA Orange Book 31st Edition (2011): FDA Orange Book 31st Edition (2011) |date=2011 |publisher=DrugPatentWatch.com |isbn=978-1-934899-81-6 |page=344 |url=https://books.google.com/books?id=JDZ4DAAAQBAJ&pg=PR344 |access-date=4 March 2019 |archive-url=https://web.archive.org/web/20190306043352/https://books.google.ca/books?id=JDZ4DAAAQBAJ&pg=PR344 |archive-date=6 March 2019 |url-status=live}}</ref> E dey on de World Health Organization's List of Essential Medicines.<ref name="WHO23rd">{{cite book | vauthors = ((World Health Organization)) | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref> E be available as a generic medication.<ref name=BNF76>{{cite book|title=British national formulary: BNF 76 |date=2018 |publisher=Pharmaceutical Press |isbn=978-0-85711-338-2|pages=363|edition=76}}</ref> Insyd 2023, na e be de 72nd most commonly prescribed medication insyd de United States, plus more dan 9{{nbsp}}million prescriptions.<ref name="Top300Drugs">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref name="ClinCalc Paroxetine">{{cite web | title = Paroxetine Drug Usage Statistics, United States, 2013 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Paroxetine | access-date = 18 August 2025 }}</ref> Insyd 2018, na e dey insyd de top 10 of most prescribed antidepressants insyd de United States.<ref>{{Cite web |vauthors=Grohol JM |date=15 December 2019 |title=Top 25 Psychiatric Medications for 2018 |url=https://psychcentral.com/blog/top-25-psychiatric-medications-for-2018/ |access-date=26 September 2020 |website=psychcentral.com |archive-date=25 October 2020 |archive-url=https://web.archive.org/web/20201025001611/https://psychcentral.com/blog/top-25-psychiatric-medications-for-2018/ |url-status=live }}</ref>
== References ==
<references />
== External links ==
{{Commons}}
[[Category:Antidepressants]]
[[Category:Benzodioxoles]]
[[Category:CYP2B6 inhibitors]]
[[Category:CYP2D6 inhibitors]]
[[Category:4-Fluorophenyl compounds]]
[[Category:Drugs wey GSK plc develop]]
[[Category:Muscarinic antagonists]]
[[Category:Phenol ethers]]
[[Category:4-Phenylpiperidines]]
[[Category:Premature ejaculation drugs]]
[[Category:Psychiatry controversies]]
[[Category:Selective serotonin reuptake inhibitors]]
[[Category:Translated from MDWiki]]
j7g18c7ulsoaxoicggm8gv841hdjgj6
Category:Benzodioxoles
14
26920
98215
2026-05-17T15:57:14Z
DaSupremo
9
Fresh category
98215
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Tizanidine
0
26921
98216
2026-05-17T16:00:51Z
DaSupremo
9
Created by translating the page [[:mdwiki:Special:Redirect/revision/1456885|Tizanidine]] to:gpe #mdwikicx
98216
wikitext
text/x-wiki
[[Category:Translated from MDWiki]]
r0gf7axtnvt68k0p85plnlehx64o08u
98217
98216
2026-05-17T16:18:54Z
DaSupremo
9
Improve article
98217
wikitext
text/x-wiki
{{Databox}}
'''Tizanidine''', dem sell under de brand name '''Zanaflex''' among odas, be an alpha-2 (α<sub>2</sub>) adrenergic receptor agonist,<ref name="Katzung2">{{Cite book |title=Basic & clinical pharmacology |vauthors=Katzung BG |date=30 November 2017 |publisher=McGraw Hill Education |isbn=9781259641152 |edition=14th |location=New York |page=487 |oclc=1015240036}}</ref> similar to [[clonidine]], wey be used to treat muscle spasticity secof spinal cord injury, [[multiple sclerosis]], den spastic cerebral palsy.<ref name=BNF76>{{cite book|title=British national formulary: BNF 76|date=2018|publisher=Pharmaceutical Press|isbn=9780857113382|pages=1094|edition= 76}}</ref> Effectiveness dey appear similar to baclofen anaa [[diazepam]].<ref name=Kam2008>{{cite journal | vauthors = Kamen L, Henney HR, Runyan JD | title = A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury | journal = Current Medical Research and Opinion | volume = 24 | issue = 2 | pages = 425–439 | date = February 2008 | pmid = 18167175 | doi = 10.1185/030079908X261113 | s2cid = 73086671 }}</ref> Dem dey take am by mouth.<ref name="AHFS20192">{{cite web |title=Tizanidine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/tizanidine-hydrochloride.html |access-date=3 March 2019 |website=Drugs.com |publisher=American Society of Health-System Pharmacists}}</ref>
== References ==
[[Category:Translated from MDWiki]]
<references />
== External links ==
c95wucsd3imzs8ihs18ezo990n7gmft
98218
98217
2026-05-17T16:22:22Z
DaSupremo
9
Improve article
98218
wikitext
text/x-wiki
{{Databox}}
'''Tizanidine''', dem sell under de brand name '''Zanaflex''' among odas, be an alpha-2 (α<sub>2</sub>) adrenergic receptor agonist,<ref name="Katzung2">{{Cite book |title=Basic & clinical pharmacology |vauthors=Katzung BG |date=30 November 2017 |publisher=McGraw Hill Education |isbn=9781259641152 |edition=14th |location=New York |page=487 |oclc=1015240036}}</ref> similar to [[clonidine]], wey be used to treat muscle spasticity secof spinal cord injury, [[multiple sclerosis]], den spastic cerebral palsy.<ref name=BNF76>{{cite book|title=British national formulary: BNF 76|date=2018|publisher=Pharmaceutical Press|isbn=9780857113382|pages=1094|edition= 76}}</ref> Effectiveness dey appear similar to baclofen anaa [[diazepam]].<ref name=Kam2008>{{cite journal | vauthors = Kamen L, Henney HR, Runyan JD | title = A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury | journal = Current Medical Research and Opinion | volume = 24 | issue = 2 | pages = 425–439 | date = February 2008 | pmid = 18167175 | doi = 10.1185/030079908X261113 | s2cid = 73086671 }}</ref> Dem dey take am by mouth.<ref name="AHFS20192">{{cite web |title=Tizanidine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/tizanidine-hydrochloride.html |access-date=3 March 2019 |website=Drugs.com |publisher=American Society of Health-System Pharmacists}}</ref>
Common side effects of tizanidine dey include [[Xerostomia|dry mouth]], sleepiness, weakness, den dizziness.<ref name=AHFS2019/> Serious side effects fi include low blood pressure, liver problems, [[psychosis]], den QT prolongation.<ref name=AHFS2019/> E be unclear if use insyd [[pregnancy]] den [[breastfeeding]] be safe.<ref name=Preg2019>{{cite web |title=Tizanidine Pregnancy and Breastfeeding Warnings |url=https://www.drugs.com/pregnancy/tizanidine.html |website=Drugs.com |access-date=3 March 2019 }}</ref> E be an α<sub>2</sub>-adrenergic agonist, buh how e dey work no be entirely clear.<ref name=AHFS2019>{{cite web |title=Tizanidine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/tizanidine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |access-date=3 March 2019 }}</ref>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
l3gqivck6ynaswplpq1w1lj2gsjog4c
98219
98218
2026-05-17T16:24:12Z
DaSupremo
9
Improve article
98219
wikitext
text/x-wiki
{{Databox}}
'''Tizanidine''', dem sell under de brand name '''Zanaflex''' among odas, be an alpha-2 (α<sub>2</sub>) adrenergic receptor agonist,<ref name="Katzung2">{{Cite book |title=Basic & clinical pharmacology |vauthors=Katzung BG |date=30 November 2017 |publisher=McGraw Hill Education |isbn=9781259641152 |edition=14th |location=New York |page=487 |oclc=1015240036}}</ref> similar to [[clonidine]], wey be used to treat muscle spasticity secof spinal cord injury, [[multiple sclerosis]], den spastic cerebral palsy.<ref name=BNF76>{{cite book|title=British national formulary: BNF 76|date=2018|publisher=Pharmaceutical Press|isbn=9780857113382|pages=1094|edition= 76}}</ref> Effectiveness dey appear similar to baclofen anaa [[diazepam]].<ref name=Kam2008>{{cite journal | vauthors = Kamen L, Henney HR, Runyan JD | title = A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury | journal = Current Medical Research and Opinion | volume = 24 | issue = 2 | pages = 425–439 | date = February 2008 | pmid = 18167175 | doi = 10.1185/030079908X261113 | s2cid = 73086671 }}</ref> Dem dey take am by mouth.<ref name="AHFS20192">{{cite web |title=Tizanidine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/tizanidine-hydrochloride.html |access-date=3 March 2019 |website=Drugs.com |publisher=American Society of Health-System Pharmacists}}</ref>
Common side effects of tizanidine dey include [[Xerostomia|dry mouth]], sleepiness, weakness, den dizziness.<ref name=AHFS2019/> Serious side effects fi include low blood pressure, liver problems, [[psychosis]], den QT prolongation.<ref name=AHFS2019/> E be unclear if use insyd [[pregnancy]] den [[breastfeeding]] be safe.<ref name=Preg2019>{{cite web |title=Tizanidine Pregnancy and Breastfeeding Warnings |url=https://www.drugs.com/pregnancy/tizanidine.html |website=Drugs.com |access-date=3 March 2019 }}</ref> E be an α<sub>2</sub>-adrenergic agonist, buh how e dey work no be entirely clear.<ref name=AHFS2019>{{cite web |title=Tizanidine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/tizanidine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |access-date=3 March 2019 }}</ref>
Na dem approve tizanidine for medical use insyd de [[United States]] insyd 1996.<ref name=AHFS2019/> E be available as a generic medication.<ref name=BNF76/> Insyd 2023, na e be de 81st most commonly prescribed medication insyd de United States, plus more dan 8{{nbsp}}million prescriptions.<ref name="Top300Drugs">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Tizanidine Drug Usage Statistics, United States, 2013 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Tizanidine | access-date = 18 August 2025 }}</ref>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
96h86vq2k6dlmc2smkv9mbqhmip6jb8
98220
98219
2026-05-17T16:29:33Z
DaSupremo
9
Improve article
98220
wikitext
text/x-wiki
{{Databox}}
'''Tizanidine''', dem sell under de brand name '''Zanaflex''' among odas, be an alpha-2 (α<sub>2</sub>) adrenergic receptor agonist,<ref name="Katzung2">{{Cite book |title=Basic & clinical pharmacology |vauthors=Katzung BG |date=30 November 2017 |publisher=McGraw Hill Education |isbn=9781259641152 |edition=14th |location=New York |page=487 |oclc=1015240036}}</ref> similar to [[clonidine]], wey be used to treat muscle spasticity secof spinal cord injury, [[multiple sclerosis]], den spastic cerebral palsy.<ref name=BNF76>{{cite book|title=British national formulary: BNF 76|date=2018|publisher=Pharmaceutical Press|isbn=9780857113382|pages=1094|edition= 76}}</ref> Effectiveness dey appear similar to baclofen anaa [[diazepam]].<ref name=Kam2008>{{cite journal | vauthors = Kamen L, Henney HR, Runyan JD | title = A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury | journal = Current Medical Research and Opinion | volume = 24 | issue = 2 | pages = 425–439 | date = February 2008 | pmid = 18167175 | doi = 10.1185/030079908X261113 | s2cid = 73086671 }}</ref> Dem dey take am by mouth.<ref name="AHFS20192">{{cite web |title=Tizanidine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/tizanidine-hydrochloride.html |access-date=3 March 2019 |website=Drugs.com |publisher=American Society of Health-System Pharmacists}}</ref>
Common side effects of tizanidine dey include [[Xerostomia|dry mouth]], sleepiness, weakness, den dizziness.<ref name=AHFS2019/> Serious side effects fi include low blood pressure, liver problems, [[psychosis]], den QT prolongation.<ref name=AHFS2019/> E be unclear if use insyd [[pregnancy]] den [[breastfeeding]] be safe.<ref name=Preg2019>{{cite web |title=Tizanidine Pregnancy and Breastfeeding Warnings |url=https://www.drugs.com/pregnancy/tizanidine.html |website=Drugs.com |access-date=3 March 2019 }}</ref> E be an α<sub>2</sub>-adrenergic agonist, buh how e dey work no be entirely clear.<ref name=AHFS2019>{{cite web |title=Tizanidine Hydrochloride Monograph for Professionals |url=https://www.drugs.com/monograph/tizanidine-hydrochloride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |access-date=3 March 2019 }}</ref>
Na dem approve tizanidine for medical use insyd de [[United States]] insyd 1996.<ref name=AHFS2019/> E be available as a generic medication.<ref name=BNF76/> Insyd 2023, na e be de 81st most commonly prescribed medication insyd de United States, plus more dan 8{{nbsp}}million prescriptions.<ref name="Top300Drugs">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Tizanidine Drug Usage Statistics, United States, 2013 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Tizanidine | access-date = 18 August 2025 }}</ref>
== References ==
<references />
== External links ==
{{Commons}}
[[Category:Muscle relaxants]]
[[Category:Alpha2-adrenergic agonists]]
[[Category:Imidazolines]]
[[Category:Drugs wey Novartis develop]]
[[Category:Organochlorides]]
[[Category:Benzothiadiazoles]]
[[Category:Translated from MDWiki]]
2yar4xo4dr6gfpxmfi483lj3od5l50l
Category:Benzothiadiazoles
14
26922
98221
2026-05-17T16:29:58Z
DaSupremo
9
Fresh category
98221
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Pembrolizumab
0
26923
98222
2026-05-17T17:16:45Z
DaSupremo
9
Created by translating the page [[:mdwiki:Special:Redirect/revision/1469060|Pembrolizumab]] to:gpe #mdwikicx
98222
wikitext
text/x-wiki
[[Category:Translated from MDWiki]]
r0gf7axtnvt68k0p85plnlehx64o08u
98223
98222
2026-05-17T18:10:06Z
DaSupremo
9
Improve article
98223
wikitext
text/x-wiki
{{Databox}}
'''Pembrolizumab''', dem sell under de brand name '''Keytruda''', be a humanized monoclonal antibody, more specifically a PD-1 inhibitor, dem use insyd cancer immunotherapy to treat chaw types of cancer.<ref name="Keytruda label2">{{cite web |date=17 September 2019 |title=Keytruda- pembrolizumab injection, powder, lyophilized, for solution Keytruda- pembrolizumab injection, solution |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287 |url-status=live |archive-url=https://web.archive.org/web/20200617124927/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287 |archive-date=17 June 2020 |access-date=10 January 2020 |website=DailyMed}}</ref><ref name=AHFS2019/> E be administered by slow intravenous injection.<ref name=AHFS2019>{{cite web |title=Pembrolizumab Monograph for Professionals |url=https://www.drugs.com/monograph/pembrolizumab.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |access-date=15 July 2019 |archive-date=14 June 2020 |archive-url=https://web.archive.org/web/20200614060420/https://www.drugs.com/monograph/pembrolizumab.html |url-status=live }}</ref>
== References ==
[[Category:Translated from MDWiki]]
<references />
== External links ==
cx008d7o5bezp7h45my5swl1igpyp6w
98224
98223
2026-05-17T18:13:58Z
DaSupremo
9
Improve article
98224
wikitext
text/x-wiki
{{Databox}}
'''Pembrolizumab''', dem sell under de brand name '''Keytruda''', be a humanized monoclonal antibody, more specifically a PD-1 inhibitor, dem use insyd cancer immunotherapy to treat chaw types of cancer.<ref name="Keytruda label2">{{cite web |date=17 September 2019 |title=Keytruda- pembrolizumab injection, powder, lyophilized, for solution Keytruda- pembrolizumab injection, solution |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287 |url-status=live |archive-url=https://web.archive.org/web/20200617124927/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287 |archive-date=17 June 2020 |access-date=10 January 2020 |website=DailyMed}}</ref><ref name=AHFS2019/> E be administered by slow intravenous injection.<ref name=AHFS2019>{{cite web |title=Pembrolizumab Monograph for Professionals |url=https://www.drugs.com/monograph/pembrolizumab.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |access-date=15 July 2019 |archive-date=14 June 2020 |archive-url=https://web.archive.org/web/20200614060420/https://www.drugs.com/monograph/pembrolizumab.html |url-status=live }}</ref>
Common side effects dey include fatigue, musculoskeletal pain, decreased appetite, itchy skin, [[diarrhea]], nausea, rash, fever, cough, difficulty breathing, constipation, pain, den abdominal pain.<ref name=AHFS2019/><ref name="FDA PR 202006292">{{cite press release|title=FDA Approves First-Line Immunotherapy for Patients with MSI-H/dMMR Metastatic Colorectal Cancer|publisher=U.S. [[Food and Drug Administration]] (FDA)|date=29 June 2020|url=https://www.fda.gov/news-events/press-announcements/fda-approves-first-line-immunotherapy-patients-msi-hdmmr-metastatic-colorectal-cancer|access-date=29 June 2020|archive-date=29 June 2020|archive-url=https://web.archive.org/web/20200629220520/https://www.fda.gov/news-events/press-announcements/fda-approves-first-line-immunotherapy-patients-msi-hdmmr-metastatic-colorectal-cancer}}</ref> E be an IgG4 isotype antibody wey dey block a protective mechanism of cancer cells, wey dey allow de immune system to destroy dem. E dey target de programmed cell death protein 1 (PD-1) receptor of lymphocytes.<ref name="FDA PR 202006292" />
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
kkoj9aaetwf019n5dsvtaruy56e5b65
98225
98224
2026-05-17T18:17:38Z
DaSupremo
9
Improve article
98225
wikitext
text/x-wiki
{{Databox}}
'''Pembrolizumab''', dem sell under de brand name '''Keytruda''', be a humanized monoclonal antibody, more specifically a PD-1 inhibitor, dem use insyd cancer immunotherapy to treat chaw types of cancer.<ref name="Keytruda label2">{{cite web |date=17 September 2019 |title=Keytruda- pembrolizumab injection, powder, lyophilized, for solution Keytruda- pembrolizumab injection, solution |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287 |url-status=live |archive-url=https://web.archive.org/web/20200617124927/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287 |archive-date=17 June 2020 |access-date=10 January 2020 |website=DailyMed}}</ref><ref name=AHFS2019/> E be administered by slow intravenous injection.<ref name=AHFS2019>{{cite web |title=Pembrolizumab Monograph for Professionals |url=https://www.drugs.com/monograph/pembrolizumab.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |access-date=15 July 2019 |archive-date=14 June 2020 |archive-url=https://web.archive.org/web/20200614060420/https://www.drugs.com/monograph/pembrolizumab.html |url-status=live }}</ref>
Common side effects dey include fatigue, musculoskeletal pain, decreased appetite, itchy skin, [[diarrhea]], nausea, rash, fever, cough, difficulty breathing, constipation, pain, den abdominal pain.<ref name=AHFS2019/><ref name="FDA PR 202006292">{{cite press release|title=FDA Approves First-Line Immunotherapy for Patients with MSI-H/dMMR Metastatic Colorectal Cancer|publisher=U.S. [[Food and Drug Administration]] (FDA)|date=29 June 2020|url=https://www.fda.gov/news-events/press-announcements/fda-approves-first-line-immunotherapy-patients-msi-hdmmr-metastatic-colorectal-cancer|access-date=29 June 2020|archive-date=29 June 2020|archive-url=https://web.archive.org/web/20200629220520/https://www.fda.gov/news-events/press-announcements/fda-approves-first-line-immunotherapy-patients-msi-hdmmr-metastatic-colorectal-cancer}}</ref> E be an IgG4 isotype antibody wey dey block a protective mechanism of cancer cells, wey dey allow de immune system to destroy dem. E dey target de programmed cell death protein 1 (PD-1) receptor of lymphocytes.<ref name="FDA PR 202006292" />
Dem approve pembrolizumab for medical use insyd de [[United States]] insyd 2014.<ref name=AHFS2019/><ref>{{cite web | title=Drug Approval Package: Keytruda (pembrolizumab) Powder for Injection NDA #125514 | website=U.S. [[Food and Drug Administration]] (FDA) | date=2 October 2014 | url=https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/125514Orig1s000TOC.cfm | access-date=21 September 2025}}</ref> E dey on de World Health Organization's List of Essential Medicines.<ref name="WHO24th">{{cite book | title = The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list | year = 2025 | hdl = 10665/382243 | publisher = [[World Health Organization]] | location = Geneva | hdl-access = free | doi = 10.2471/B09474 | doi-access = free | id = License: CC BY-NC-SA 3.0 IGO }}</ref> Na dem approve a fixed-dose combination of pembrolizumab den berahyaluronidase alfa, (Keytruda Qlex) for medical use insyd de United States insyd September 2025.<ref>{{cite web | title=FDA approves pembrolizumab and berahyaluronidase alfa-pmph | website=U.S. [[Food and Drug Administration]] (FDA) | date=19 September 2025 | url=https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-pembrolizumab-and-berahyaluronidase-alfa-pmph-subcutaneous-injection | access-date=21 September 2025}}</ref><ref>{{cite press release | title=FDA Approves Merck's Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) Injection for Subcutaneous Use in Adults Across Most Solid Tumor Indications for Keytruda (pembrolizumab) | website=Merck | date=21 September 2025 | url=https://www.merck.com/news/fda-approves-mercks-keytruda-qlex-pembrolizumab-and-berahyaluronidase-alfa-pmph-injection-for-subcutaneous-use-in-adults-across-most-solid-tumor-indications-for-keytruda-pem/ | access-date=21 September 2025}}</ref>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
hbugv1266ooq8lhxtb1ykc93cyx63ns
98226
98225
2026-05-17T18:21:01Z
DaSupremo
9
Improve article
98226
wikitext
text/x-wiki
{{Databox}}
'''Pembrolizumab''', dem sell under de brand name '''Keytruda''', be a humanized monoclonal antibody, more specifically a PD-1 inhibitor, dem use insyd cancer immunotherapy to treat chaw types of cancer.<ref name="Keytruda label2">{{cite web |date=17 September 2019 |title=Keytruda- pembrolizumab injection, powder, lyophilized, for solution Keytruda- pembrolizumab injection, solution |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287 |url-status=live |archive-url=https://web.archive.org/web/20200617124927/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9333c79b-d487-4538-a9f0-71b91a02b287 |archive-date=17 June 2020 |access-date=10 January 2020 |website=DailyMed}}</ref><ref name=AHFS2019/> E be administered by slow intravenous injection.<ref name=AHFS2019>{{cite web |title=Pembrolizumab Monograph for Professionals |url=https://www.drugs.com/monograph/pembrolizumab.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |access-date=15 July 2019 |archive-date=14 June 2020 |archive-url=https://web.archive.org/web/20200614060420/https://www.drugs.com/monograph/pembrolizumab.html |url-status=live }}</ref>
Common side effects dey include fatigue, musculoskeletal pain, decreased appetite, itchy skin, [[diarrhea]], nausea, rash, fever, cough, difficulty breathing, constipation, pain, den abdominal pain.<ref name=AHFS2019/><ref name="FDA PR 202006292">{{cite press release|title=FDA Approves First-Line Immunotherapy for Patients with MSI-H/dMMR Metastatic Colorectal Cancer|publisher=U.S. [[Food and Drug Administration]] (FDA)|date=29 June 2020|url=https://www.fda.gov/news-events/press-announcements/fda-approves-first-line-immunotherapy-patients-msi-hdmmr-metastatic-colorectal-cancer|access-date=29 June 2020|archive-date=29 June 2020|archive-url=https://web.archive.org/web/20200629220520/https://www.fda.gov/news-events/press-announcements/fda-approves-first-line-immunotherapy-patients-msi-hdmmr-metastatic-colorectal-cancer}}</ref> E be an IgG4 isotype antibody wey dey block a protective mechanism of cancer cells, wey dey allow de immune system to destroy dem. E dey target de programmed cell death protein 1 (PD-1) receptor of lymphocytes.<ref name="FDA PR 202006292" />
Dem approve pembrolizumab for medical use insyd de [[United States]] insyd 2014.<ref name=AHFS2019/><ref>{{cite web | title=Drug Approval Package: Keytruda (pembrolizumab) Powder for Injection NDA #125514 | website=U.S. [[Food and Drug Administration]] (FDA) | date=2 October 2014 | url=https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/125514Orig1s000TOC.cfm | access-date=21 September 2025}}</ref> E dey on de World Health Organization's List of Essential Medicines.<ref name="WHO24th">{{cite book | title = The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list | year = 2025 | hdl = 10665/382243 | publisher = [[World Health Organization]] | location = Geneva | hdl-access = free | doi = 10.2471/B09474 | doi-access = free | id = License: CC BY-NC-SA 3.0 IGO }}</ref> Na dem approve a fixed-dose combination of pembrolizumab den berahyaluronidase alfa, (Keytruda Qlex) for medical use insyd de United States insyd September 2025.<ref>{{cite web | title=FDA approves pembrolizumab and berahyaluronidase alfa-pmph | website=U.S. [[Food and Drug Administration]] (FDA) | date=19 September 2025 | url=https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-pembrolizumab-and-berahyaluronidase-alfa-pmph-subcutaneous-injection | access-date=21 September 2025}}</ref><ref>{{cite press release | title=FDA Approves Merck's Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) Injection for Subcutaneous Use in Adults Across Most Solid Tumor Indications for Keytruda (pembrolizumab) | website=Merck | date=21 September 2025 | url=https://www.merck.com/news/fda-approves-mercks-keytruda-qlex-pembrolizumab-and-berahyaluronidase-alfa-pmph-injection-for-subcutaneous-use-in-adults-across-most-solid-tumor-indications-for-keytruda-pem/ | access-date=21 September 2025}}</ref>
== References ==
<references />
== Read further ==
* {{cite journal | vauthors = Kang SP, Gergich K, Lubiniecki GM, de Alwis DP, Chen C, Tice MA, Rubin EH | title = Pembrolizumab KEYNOTE-001: an adaptive study leading to accelerated approval for two indications and a companion diagnostic | journal = Annals of Oncology | volume = 28 | issue = 6 | pages = 1388–1398 | date = June 2017 | pmid = 30052728 | pmc = 5452070 | doi = 10.1093/annonc/mdx076 }}
== External links ==
{{Commons}}
* {{cite web | title=Pembrolizumab | website=[[National Cancer Institute]] | date=18 September 2014 | url=https://www.cancer.gov/about-cancer/treatment/drugs/pembrolizumab }}
* [https://meshb.nlm.nih.gov/record/ui?name=Pembrolizumab Pembrolizumab] at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
[[Category:Antineoplastic drugs]]
[[Category:Cancer immunotherapy]]
[[Category:Drugs wey Merck & Co. develop]]
[[Category:Monoclonal antibodies for tumors]]
[[Category:Orphan drugs]]
[[Category:Tissue agnostic antineoplastic agents]]
[[Category:World Health Organization essential medicines]]
[[Category:Translated from MDWiki]]
de31vwanqnerqfxmegt1vd7nc4fxzn3
Category:Cancer immunotherapy
14
26924
98227
2026-05-17T18:21:22Z
DaSupremo
9
Fresh category
98227
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:Monoclonal antibodies for tumors
14
26925
98228
2026-05-17T18:21:31Z
DaSupremo
9
Fresh category
98228
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Category:Tissue agnostic antineoplastic agents
14
26926
98229
2026-05-17T18:21:40Z
DaSupremo
9
Fresh category
98229
wikitext
text/x-wiki
phoiac9h4m842xq45sp7s6u21eteeq1
Post COVID-19 condition
0
26927
98230
2026-05-18T03:40:43Z
Yaw tuba
7
Created by translating the page [[:mdwiki:Special:Redirect/revision/1490571|Post COVID-19 condition]] to:gpe #mdwikicx
98230
wikitext
text/x-wiki
'''Post COVID-19 condition''', wey dey include '''long COVID''', be group of conditions wey dey occur after say you get[[COVID-19]]. Edey involve symptoms wey dey occur four anaa more weeks after de initial infection.<ref name=CDC2021Sept>{{cite web |title=COVID-19 and Your Health |url=https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html |website=Centers for Disease Control and Prevention |access-date=20 January 2022 |language=en-us |date=11 February 2020 |archive-date=14 January 2022 |archive-url=https://web.archive.org/web/20220114190825/https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html |url-status=live }} {{Webarchive|url=https://web.archive.org/web/20220114190825/https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html |date=14 January 2022 }}</ref> Symptoms go fi include tiredness, shortness of breath, headaches, anxiety den depression, loss of smell, difficulty concentrating, headaches, fever, den palpitations.<ref name=CDC2021Sept /> Symptoms sana go fi make worse plus activity.<ref name=CDC2021Sept />
It may occur in anyone following COVID-19, regardless of the severity of the original infection. A number of cases have occurred among vaccinated individuals, though it is less common in this group. Those who have had severe illness may also have damage to multiple organ systems, develop [[Autoimmune disease|autoimmune conditions]], post-intensive care syndrome (PICS), or [[post-traumatic stress disorder]] (PTSD).<ref name=CDC2021Sept /> Children may experience multisystem inflammatory syndrome in children (MIS-C).<ref name=CDC2021Sept />
The case definition is still being developed. There are no specific laboratory or imaging findings that confirm or rules out the condition; though other potential causes should be excluded.
Prevention is by preventing COVID-19, including vaccination, physical distancing, and wearing a face mask. Treatment involves efforts to address specific symptoms and improve physical, mental, and social wellbeing. Specialized clinics have been created, in certain jurisdictions, to try to address the condition. About 20% of people diagnosed with COVID have symptoms for longer than 4 weeks and 10% of people for longer than 12 weeks. Women are more commonly affected than men.
== References ==
{{Reflist}}
[[Category:Translated from MDWiki]]
nltpxa7xjamrlzz3wfviujal6cnlvkk
98231
98230
2026-05-18T03:58:22Z
Yaw tuba
7
Created by translating the page [[:mdwiki:Special:Redirect/revision/1490571|Post COVID-19 condition]] to:gpe #mdwikicx
98231
wikitext
text/x-wiki
'''Post COVID-19 condition''', wey dey include '''long COVID''', be group of conditions wey dey occur after say you get[[COVID-19]]. Edey involve symptoms wey dey occur four anaa more weeks after de initial infection.<ref name=CDC2021Sept>{{cite web |title=COVID-19 and Your Health |url=https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html |website=Centers for Disease Control and Prevention |access-date=20 January 2022 |language=en-us |date=11 February 2020 |archive-date=14 January 2022 |archive-url=https://web.archive.org/web/20220114190825/https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html |url-status=live }} {{Webarchive|url=https://web.archive.org/web/20220114190825/https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html |date=14 January 2022 }}</ref> Symptoms go fi include tiredness, shortness of breath, headaches, anxiety den depression, loss of smell, difficulty concentrating, headaches, fever, den palpitations.<ref name=CDC2021Sept /> Symptoms sana go fi make worse plus activity.<ref name=CDC2021Sept />
Ego fi occur insyd anybro following COVID-19, regardless of de severity of de original infection. A number of cases occur among vaccinated individuals, though ebe less common insyd dis group. Menners wey get severe illness go fi get damage to chao organ systems, develop [[Autoimmune disease|autoimmune conditions]], post-intensive care syndrome (PICS), anaa [[post-traumatic stress disorder]] (PTSD).<ref name=CDC2021Sept /> Children go fi experience multisystem inflammatory syndrome insyd kiddies (MIS-C).<ref name=CDC2021Sept />
De case definition still dey develop. No specific laboratory anaa imaging findings dey wey dey confirm anaa edey rule out de condition; though other potential causes nor for dey mong.
Prevention be by say you go prevent COVID-19, wey dey include vaccination, physical distancing, den say you go wear face mask. Treatment dey involve efforts wey go address specific symptoms den improve physical, mental, den social wellbeing. Dem create Specialized clinics, insyd certain jurisdictions, so say dem go try address de condition. About 20% of menners wey be diagnosed of COVID get symptoms for longer than 4 weeks den 10% of menners for longer than 12 weeks. Edey affect shoddies pass guys
== References ==
{{Reflist}}
[[Category:Translated from MDWiki]]
fqb9jmrbikwrl4j56aiahbp8wh0wrv8
98232
98231
2026-05-18T04:00:11Z
Yaw tuba
7
added databox #GhPidgin
98232
wikitext
text/x-wiki
{{Databox}}
'''Post COVID-19 condition''', wey dey include '''long COVID''', be group of conditions wey dey occur after say you get[[COVID-19]]. Edey involve symptoms wey dey occur four anaa more weeks after de initial infection.<ref name=CDC2021Sept>{{cite web |title=COVID-19 and Your Health |url=https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html |website=Centers for Disease Control and Prevention |access-date=20 January 2022 |language=en-us |date=11 February 2020 |archive-date=14 January 2022 |archive-url=https://web.archive.org/web/20220114190825/https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html |url-status=live }} {{Webarchive|url=https://web.archive.org/web/20220114190825/https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html |date=14 January 2022 }}</ref> Symptoms go fi include tiredness, shortness of breath, headaches, anxiety den depression, loss of smell, difficulty concentrating, headaches, fever, den palpitations.<ref name=CDC2021Sept /> Symptoms sana go fi make worse plus activity.<ref name=CDC2021Sept />
Ego fi occur insyd anybro following COVID-19, regardless of de severity of de original infection. A number of cases occur among vaccinated individuals, though ebe less common insyd dis group. Menners wey get severe illness go fi get damage to chao organ systems, develop [[Autoimmune disease|autoimmune conditions]], post-intensive care syndrome (PICS), anaa [[post-traumatic stress disorder]] (PTSD).<ref name=CDC2021Sept /> Children go fi experience multisystem inflammatory syndrome insyd kiddies (MIS-C).<ref name=CDC2021Sept />
De case definition still dey develop. No specific laboratory anaa imaging findings dey wey dey confirm anaa edey rule out de condition; though other potential causes nor for dey mong.
Prevention be by say you go prevent COVID-19, wey dey include vaccination, physical distancing, den say you go wear face mask. Treatment dey involve efforts wey go address specific symptoms den improve physical, mental, den social wellbeing. Dem create Specialized clinics, insyd certain jurisdictions, so say dem go try address de condition. About 20% of menners wey be diagnosed of COVID get symptoms for longer than 4 weeks den 10% of menners for longer than 12 weeks. Edey affect shoddies pass guys
== References ==
{{Reflist}}
[[Category:Translated from MDWiki]]
7e5yuv567h1mn73pbixnfj1tlxmsjp8
Sodium nitrite (medical use)
0
26928
98233
2026-05-18T04:18:22Z
Yaw tuba
7
Created by translating the page [[:mdwiki:Special:Redirect/revision/1457191|Sodium nitrite (medical use)]] to:gpe #mdwikicx
98233
wikitext
text/x-wiki
'''Sodium nitrite''' be samtin dey dey use as medication together plus sodium thiosulfate treat [[cyanide poisoning]].<ref name="WHO2008" /> Dem only dey recommend insyd severe cases of cyanide poisoning.<ref name="UK2017">{{Cite web|title=Sodium Nitrite Solution for Injection - Summary of Product Characteristics (SPC) - (eMC)|url=https://www.medicines.org.uk/emc/medicine/32282|website=www.medicines.org.uk|access-date=15 January 2017|url-status=live|archive-url=https://web.archive.org/web/20170918184748/https://www.medicines.org.uk/emc/medicine/32282|archive-date=18 September 2017|df=}}</ref> Menners wey get both cyanide poisoning den [[carbon monoxide poisoning]], dem usually dey recommend sodium thiosulfate.<ref>{{Cite book|last=Baren|first=Jill M.|title=Pediatric Emergency Medicine|date=2008|publisher=Elsevier Health Sciences|isbn=978-1416000877|page=1018|url=https://books.google.ca/books?id=wpvux6RS-jsC&pg=PA1018|language=en|url-status=live|archive-url=https://web.archive.org/web/20170116172656/https://books.google.ca/books?id=wpvux6RS-jsC&pg=PA1018|archive-date=2017-01-16|df=}}</ref> Dem dey take give menners by slow injection go de vein insyd.<ref name="WHO2008">{{Cite book|title=WHO Model Formulary 2008|year=2009|isbn=9789241547659|vauthors=((World Health Organization))|veditors=Stuart MC, Kouimtzi M, Hill SR|hdl=10665/44053|author-link=World Health Organization|publisher=World Health Organization|hdl-access=free|page=65}}</ref>
Side effects go fi include low blood pressure, headache, shortness of breath, loss of consciousness, den vomiting.<ref name="WHO2008" /> Dem for give greater care to menners plus underlying heart disease.<ref name="WHO2008" /> Menners for check demma levels of methemoglobin regularly during treatment.<ref name="WHO2008" /> While not well studied during [[pregnancy]], Some evidence of potential dey say ego fi harm kiddie.<ref name="Pro2017" /> Dem dey believe say Sodium nitrite dey work by say edey create methemoglobin wey dey bind plus cyanide den remove am from de mitochondria.<ref name="Pro2017">{{Cite web|title=Sodium Nitrite Injection - FDA prescribing information, side effects and uses|url=https://www.drugs.com/pro/sodium-nitrite-injection.html|website=www.drugs.com|url-status=live|archive-url=https://web.archive.org/web/20170118044431/https://www.drugs.com/pro/sodium-nitrite-injection.html|archive-date=2017-01-18|df=}}</ref>
Dem start dey use Sodium nitrite medically insyd de 1920s den 1930s.<ref>{{Cite book|last=Dart|first=Richard C.|title=Medical Toxicology|date=2004|publisher=Lippincott Williams & Wilkins|isbn=9780781728454|page=172|url=https://books.google.ca/books?id=BfdighlyGiwC&pg=PA172|language=en|url-status=live|archive-url=https://web.archive.org/web/20170116172601/https://books.google.ca/books?id=BfdighlyGiwC&pg=PA172|archive-date=2017-01-16|df=}}</ref><ref>{{Cite book|last=Bryan|first=Nathan S.|last2=Loscalzo|first2=Joseph|title=Nitrite and Nitrate in Human Health and Disease|date=2011|publisher=Springer Science & Business Media|isbn=9781607616160|page=226|url=https://books.google.ca/books?id=CDkkwVV4aMQC&pg=PA226|language=en|url-status=live|archive-url=https://web.archive.org/web/20170116173748/https://books.google.ca/books?id=CDkkwVV4aMQC&pg=PA226|archive-date=2017-01-16|df=}}</ref> Edey World Health Organization's List of Essential Medicines insyd.<ref name="WHO21st">{{Cite book|vauthors=((World Health Organization))|title=World Health Organization model list of essential medicines: 21st list 2019|year=2019|hdl=10665/325771|author-link=World Health Organization|publisher=World Health Organization|location=Geneva|id=WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO|hdl-access=free}}</ref> De cost insyd de United States, together plus sodium thiosulfate, be about US$110.<ref>{{Cite journal|last=Gasco|first=L|last2=Rosbolt|first2=MB|last3=Bebarta|first3=VS|title=Insufficient stocking of cyanide antidotes in US hospitals that provide emergency care|journal=Journal of Pharmacology & Pharmacotherapeutics|date=April 2013|volume=4|issue=2|pages=95–102|pmid=23761707|doi=10.4103/0976-500x.110875|pmc=3669589}}</ref>
== References ==
{{Reflist}}
[[Category:Translated from MDWiki]]
spvnbx62knfi5acociy0ukxfb78zqt6
98234
98233
2026-05-18T04:19:18Z
Yaw tuba
7
added databox #GhPidgin
98234
wikitext
text/x-wiki
{{Databox}}
'''Sodium nitrite''' be samtin dey dey use as medication together plus sodium thiosulfate treat [[cyanide poisoning]].<ref name="WHO2008" /> Dem only dey recommend insyd severe cases of cyanide poisoning.<ref name="UK2017">{{Cite web|title=Sodium Nitrite Solution for Injection - Summary of Product Characteristics (SPC) - (eMC)|url=https://www.medicines.org.uk/emc/medicine/32282|website=www.medicines.org.uk|access-date=15 January 2017|url-status=live|archive-url=https://web.archive.org/web/20170918184748/https://www.medicines.org.uk/emc/medicine/32282|archive-date=18 September 2017|df=}}</ref> Menners wey get both cyanide poisoning den [[carbon monoxide poisoning]], dem usually dey recommend sodium thiosulfate.<ref>{{Cite book|last=Baren|first=Jill M.|title=Pediatric Emergency Medicine|date=2008|publisher=Elsevier Health Sciences|isbn=978-1416000877|page=1018|url=https://books.google.ca/books?id=wpvux6RS-jsC&pg=PA1018|language=en|url-status=live|archive-url=https://web.archive.org/web/20170116172656/https://books.google.ca/books?id=wpvux6RS-jsC&pg=PA1018|archive-date=2017-01-16|df=}}</ref> Dem dey take give menners by slow injection go de vein insyd.<ref name="WHO2008">{{Cite book|title=WHO Model Formulary 2008|year=2009|isbn=9789241547659|vauthors=((World Health Organization))|veditors=Stuart MC, Kouimtzi M, Hill SR|hdl=10665/44053|author-link=World Health Organization|publisher=World Health Organization|hdl-access=free|page=65}}</ref>
Side effects go fi include low blood pressure, headache, shortness of breath, loss of consciousness, den vomiting.<ref name="WHO2008" /> Dem for give greater care to menners plus underlying heart disease.<ref name="WHO2008" /> Menners for check demma levels of methemoglobin regularly during treatment.<ref name="WHO2008" /> While not well studied during [[pregnancy]], Some evidence of potential dey say ego fi harm kiddie.<ref name="Pro2017" /> Dem dey believe say Sodium nitrite dey work by say edey create methemoglobin wey dey bind plus cyanide den remove am from de mitochondria.<ref name="Pro2017">{{Cite web|title=Sodium Nitrite Injection - FDA prescribing information, side effects and uses|url=https://www.drugs.com/pro/sodium-nitrite-injection.html|website=www.drugs.com|url-status=live|archive-url=https://web.archive.org/web/20170118044431/https://www.drugs.com/pro/sodium-nitrite-injection.html|archive-date=2017-01-18|df=}}</ref>
Dem start dey use Sodium nitrite medically insyd de 1920s den 1930s.<ref>{{Cite book|last=Dart|first=Richard C.|title=Medical Toxicology|date=2004|publisher=Lippincott Williams & Wilkins|isbn=9780781728454|page=172|url=https://books.google.ca/books?id=BfdighlyGiwC&pg=PA172|language=en|url-status=live|archive-url=https://web.archive.org/web/20170116172601/https://books.google.ca/books?id=BfdighlyGiwC&pg=PA172|archive-date=2017-01-16|df=}}</ref><ref>{{Cite book|last=Bryan|first=Nathan S.|last2=Loscalzo|first2=Joseph|title=Nitrite and Nitrate in Human Health and Disease|date=2011|publisher=Springer Science & Business Media|isbn=9781607616160|page=226|url=https://books.google.ca/books?id=CDkkwVV4aMQC&pg=PA226|language=en|url-status=live|archive-url=https://web.archive.org/web/20170116173748/https://books.google.ca/books?id=CDkkwVV4aMQC&pg=PA226|archive-date=2017-01-16|df=}}</ref> Edey World Health Organization's List of Essential Medicines insyd.<ref name="WHO21st">{{Cite book|vauthors=((World Health Organization))|title=World Health Organization model list of essential medicines: 21st list 2019|year=2019|hdl=10665/325771|author-link=World Health Organization|publisher=World Health Organization|location=Geneva|id=WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO|hdl-access=free}}</ref> De cost insyd de United States, together plus sodium thiosulfate, be about US$110.<ref>{{Cite journal|last=Gasco|first=L|last2=Rosbolt|first2=MB|last3=Bebarta|first3=VS|title=Insufficient stocking of cyanide antidotes in US hospitals that provide emergency care|journal=Journal of Pharmacology & Pharmacotherapeutics|date=April 2013|volume=4|issue=2|pages=95–102|pmid=23761707|doi=10.4103/0976-500x.110875|pmc=3669589}}</ref>
== References ==
{{Reflist}}
[[Category:Translated from MDWiki]]
rp62xzu92ckfoyvhe3vz6umczd8vjjv