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Methotrexate
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'''Methotrexate''', dem formerly know as '''amethopterin''', be a [[chemotherapy agent]] den [[immunosuppressive drug|immune-system suppressant]]. E be used to treat [[cancer]], [[autoimmune disease]]s, den [[ectopic pregnancy|ectopic pregnancies]]. E be used for cancers such as [[breast cancer]], [[leukemia]], [[lung cancer]], [[lymphoma]], [[gestational trophoblastic disease]], den [[osteosarcoma]], as well as autoimmune diseases such as [[psoriasis]], [[rheumatoid arthritis]], den [[Crohn's disease]]. E fi be given [[Oral administration|by mouth]] anaa by injection.<ref name="AHFS2016">{{cite web|title=Methotrexate|url=https://www.drugs.com/monograph/methotrexate.html|work=The American Society of Health-System Pharmacists|access-date=22 August 2016|url-status=live|archive-url=https://web.archive.org/web/20161008130258/https://www.drugs.com/monograph/methotrexate.html|archive-date=8 October 2016}}</ref>
Common side effects dey include nausea, feeling tired, fever, increased risk of infection, [[leukopenia|low white blood cell counts]], den [[Mucositis|breakdown of de skin insyd de mouth]]. Oda side effects fi include [[liver disease]], [[lung disease]], lymphoma, den severe skin rashes. People on long-term treatment for be regularly checked for side effects. E no be safe during [[breastfeeding]]. Insyd those plus [[kidney problem]]s, lower doses fi be needed. E dey act by blocking de body ein use of [[folic acid]], so taking folic acid supplements fi reduce ein effectiveness. [[Folinic acid]] (leucovorin) be used to reduce de side effects of methotrexate (rescue therapy).<ref name="AHFS2016" />
Dem first make methotrexate insyd 1947 wey na e be initially used to treat cancer, as na e be less toxic dan de then-current treatments.<ref>{{cite book| vauthors = Sneader W |title=Drug Discovery: A History |date=2005 |publisher=John Wiley & Sons |isbn=978-0-470-01552-0 |page=251 |url=https://books.google.com/books?id=jglFsz5EJR8C&pg=PA251 |url-status=live|archive-url=https://web.archive.org/web/20170216080949/https://books.google.com/books?id=jglFsz5EJR8C&pg=PA251|archive-date=16 February 2017}}</ref> Insyd 1956 e provide de first cures of a metastatic cancer.<ref>{{cite news|title=Today's anti-cancer tools are ever better wielded|url=https://www.economist.com/news/technology-quarterly/21728780-they-are-sharper-too-todays-anti-cancer-tools-are-ever-better-wielded|access-date=16 September 2017 |newspaper=[[The Economist]]|date=14 September 2017}}</ref> E be on de [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].<ref name="WHO23rd">{{cite book | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | publisher = [[World Health Organization]] | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref> Methotrexate be available as a [[generic medication]].<ref name=AHFS2016/> Insyd 2023, na e be de 130th most commonly prescribed medication insyd de United States, plus more dan 4{{nbsp}}million prescriptions.<ref name="Top 300">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Methotrexate Drug Usage Statistics, United States, 2014 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/Methotrexate | access-date = 18 August 2025 }}</ref>
== References ==
<references />
== External links ==
{{Commons}}
* [https://medlineplus.gov/druginfo/meds/a682018.html Methotrexate Injection] MedlinePlus article from NIH
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[[Category:Abortifacients]]
[[Category:Antifolates]]
[[Category:Antineoplastic den immunomodulating drugs]]
[[Category:Benzamides]]
[[Category:Chemotherapy]]
[[Category:Disease-modifying antirheumatic drugs]]
[[Category:Folates]]
[[Category:Hepatotoxins]]
[[Category:IARC Group 3 carcinogens]]
[[Category:Immunosuppressants]]
[[Category:Mammalian dihydrofolate reductase inhibitors]]
[[Category:Medication abortion]]
[[Category:Nephrotoxins]]
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Osteosarcoma
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An '''osteosarcoma''' ('''OS''') anaa '''osteogenic sarcoma''' ('''OGS''') be a cancerous [[tumor]] insyd a [[bone]]. Specifically, e be an aggressive [[malignant]] [[neoplasm]] wey dey arise from primitive transformed cells of [[mesenchyme|mesenchymal]] origin (den thus a [[sarcoma]]) wey dey exhibit [[osteoblast]]ic differentiation den produces malignant [[osteoid]].<ref>{{cite journal |vauthors=Luetke A, Meyers PA, Lewis A, Juergens H | year = 2014 | title = Osteosarcoma treatment—where do we stand? A state of the art review | journal = Cancer Treat Rev | volume = 40 | issue = 4| pages = 523–532 | pmid = 24345772 | doi=10.1016/j.ctrv.2013.11.006}}</ref>
Osteosarcoma be de most common [[histology|histological]] form of primary [[bone sarcoma]].<ref name="OttavianiJaffe">{{cite book |vauthors=Ottaviani G, Jaffe N |title= Pediatric and Adolescent Osteosarcoma |chapter= The Epidemiology of Osteosarcoma |series= Cancer Treatment and Research |volume= 152 |pages= 3–13 |publisher=Springer |location=New York |year=2009|isbn=978-1-4419-0283-2|pmid=20213383 |doi=10.1007/978-1-4419-0284-9_1}}</ref> E be most prevalent insyd teenagers den young adults.<ref name=":0">{{Cite web|url = https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002616/|archive-url = https://web.archive.org/web/20120828000200/http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002616/|archive-date = August 28, 2012|title = Osteosarcoma|date = 2013|website = US National Library of Medicine|publisher = PubMed Health}}</ref>
== References ==
<references />
== External links ==
{{Commons}}
* [http://www.cancer.gov/cancertopics/pdq/treatment/osteosarcoma/patient National Cancer Institute—patient information on osteosarcoma]
* [https://www.reininsarcoma.org/what-is-sarcoma-2/bone-sarcomas/osteosarcoma-an-introduction/ Osteosarcoma – An Introduction] {{Webarchive|url=https://web.archive.org/web/20201027063545/https://www.reininsarcoma.org/what-is-sarcoma-2/bone-sarcomas/osteosarcoma-an-introduction/ |date=2020-10-27 }}
* [http://sarcomahelp.org/osteosarcoma.html What is osteosarcoma?] {{Webarchive|url=https://web.archive.org/web/20090421120936/http://sarcomahelp.org/osteosarcoma.html |date=2009-04-21 }}
{{Authority control}}
[[Category:Cancer insyd cats]]
[[Category:Cancer insyd dogs]]
[[Category:Causes of amputation]]
[[Category:Osseous den chondromatous neoplasia]]
[[Category:Pediatric cancers]]
[[Category:Sarcoma]]
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'''Pneumonic plague''' be a severe [[lung infection]] wey de [[bacterium]] ''[[Yersinia pestis]]'' cause.<ref name="WHO20172">{{cite web |title=Plague |url=https://www.who.int/ith/diseases/plague/en/ |archive-url=https://web.archive.org/web/20170319114939/http://www.who.int/ith/diseases/plague/en/ |archive-date=19 March 2017 |access-date=14 March 2017 |website=www.who.int}}</ref> Symptoms dey include [[fever]], headache, [[shortness of breath]], [[chest pain]], coughing, den [[hemoptysis|coughing up blood]].<ref name="CDC20152">{{cite web |title=FAQ Plague |url=https://www.cdc.gov/plague/faq/ |url-status=live |archive-url=https://web.archive.org/web/20170314062829/https://www.cdc.gov/plague/faq/ |archive-date=14 March 2017 |access-date=13 March 2017 |website=www.cdc.gov}}</ref> Dem typically dey start about three to seven days after exposure.<ref name="WHO2016Fact2">{{cite web |date=September 2016 |title=Plague |url=https://www.who.int/mediacentre/factsheets/fs267/en/ |url-status=live |archive-url=https://web.archive.org/web/20150424065540/http://www.who.int/mediacentre/factsheets/fs267/en/ |archive-date=24 April 2015 |access-date=14 March 2017 |website=World Health Organization}}</ref> E be one of three forms of [[Plague (disease)|plague]], de oda two be [[bubonic plague]] den [[septicemic plague]].<ref name="WHO20172" />
== References ==
[[Category:Translated from MDWiki]]
<references />
== External links ==
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'''Pneumonic plague''' be a severe [[lung infection]] wey de [[bacterium]] ''[[Yersinia pestis]]'' cause.<ref name="WHO20172">{{cite web |title=Plague |url=https://www.who.int/ith/diseases/plague/en/ |archive-url=https://web.archive.org/web/20170319114939/http://www.who.int/ith/diseases/plague/en/ |archive-date=19 March 2017 |access-date=14 March 2017 |website=www.who.int}}</ref> Symptoms dey include [[fever]], headache, [[shortness of breath]], [[chest pain]], coughing, den [[hemoptysis|coughing up blood]].<ref name="CDC20152">{{cite web |title=FAQ Plague |url=https://www.cdc.gov/plague/faq/ |url-status=live |archive-url=https://web.archive.org/web/20170314062829/https://www.cdc.gov/plague/faq/ |archive-date=14 March 2017 |access-date=13 March 2017 |website=www.cdc.gov}}</ref> Dem typically dey start about three to seven days after exposure.<ref name="WHO2016Fact2">{{cite web |date=September 2016 |title=Plague |url=https://www.who.int/mediacentre/factsheets/fs267/en/ |url-status=live |archive-url=https://web.archive.org/web/20150424065540/http://www.who.int/mediacentre/factsheets/fs267/en/ |archive-date=24 April 2015 |access-date=14 March 2017 |website=World Health Organization}}</ref> E be one of three forms of [[Plague (disease)|plague]], de oda two be [[bubonic plague]] den [[septicemic plague]].<ref name="WHO20172" />
De pneumonic form fi occur following an initial bubonic anaa septicemic plague infection.<ref name=WHO2017>{{cite web|title=Plague|url=https://www.who.int/ith/diseases/plague/en/|website=www.who.int|access-date=14 March 2017|archive-url=https://web.archive.org/web/20170319114939/http://www.who.int/ith/diseases/plague/en/|archive-date=19 March 2017}}</ref> E sanso fi result from breathing insyd [[airborne disease|airborne]] droplets from anoda person anaa animal infected plus pneumonic plague.<ref name=CDC2015>{{cite web|title=FAQ Plague|url=https://www.cdc.gov/plague/faq/|website=www.cdc.gov|access-date=13 March 2017|url-status=live|archive-url=https://web.archive.org/web/20170314062829/https://www.cdc.gov/plague/faq/|archive-date=14 March 2017}}</ref> De factor wey dey differ among de three forms of plague be de location of infection; insyd pneumonic plague de infection be insyd de lungs, insyd bubonic plague de [[lymph nodes]], den insyd septicemic plague within de blood.<ref name=WHO2017/> Diagnosis be by testing de blood, sputum, anaa fluid from a lymph node.<ref name=CDC2015/>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
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'''Pneumonic plague''' be a severe [[lung infection]] wey de [[bacterium]] ''[[Yersinia pestis]]'' cause.<ref name="WHO20172">{{cite web |title=Plague |url=https://www.who.int/ith/diseases/plague/en/ |archive-url=https://web.archive.org/web/20170319114939/http://www.who.int/ith/diseases/plague/en/ |archive-date=19 March 2017 |access-date=14 March 2017 |website=www.who.int}}</ref> Symptoms dey include [[fever]], headache, [[shortness of breath]], [[chest pain]], coughing, den [[hemoptysis|coughing up blood]].<ref name="CDC20152">{{cite web |title=FAQ Plague |url=https://www.cdc.gov/plague/faq/ |url-status=live |archive-url=https://web.archive.org/web/20170314062829/https://www.cdc.gov/plague/faq/ |archive-date=14 March 2017 |access-date=13 March 2017 |website=www.cdc.gov}}</ref> Dem typically dey start about three to seven days after exposure.<ref name="WHO2016Fact2">{{cite web |date=September 2016 |title=Plague |url=https://www.who.int/mediacentre/factsheets/fs267/en/ |url-status=live |archive-url=https://web.archive.org/web/20150424065540/http://www.who.int/mediacentre/factsheets/fs267/en/ |archive-date=24 April 2015 |access-date=14 March 2017 |website=World Health Organization}}</ref> E be one of three forms of [[Plague (disease)|plague]], de oda two be [[bubonic plague]] den [[septicemic plague]].<ref name="WHO20172" />
De pneumonic form fi occur following an initial bubonic anaa septicemic plague infection.<ref name="WHO20172" /> E sanso fi result from breathing insyd [[airborne disease|airborne]] droplets from anoda person anaa animal infected plus pneumonic plague.<ref name="CDC20152" /> De factor wey dey differ among de three forms of plague be de location of infection; insyd pneumonic plague de infection be insyd de lungs, insyd bubonic plague de [[lymph nodes]], den insyd septicemic plague within de blood.<ref name="WHO20172" /> Diagnosis be by testing de blood, sputum, anaa fluid from a lymph node.<ref name="CDC20152" />
While dem dey develop [[vaccine]]s, insyd most countries dem no yet be commercially available.<ref name="WHO20172" /><ref name="CDC20152" /> Plague be present among rodents insyd [[Africa]], de Americas, den Asia.<ref name="WHO20172" /> Na de total reported number of cases of all types of plague insyd 2013 be 783.<ref name="WHO2016Fact2" />
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
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'''Pneumonic plague''' be a severe [[lung infection]] wey de [[bacterium]] ''[[Yersinia pestis]]'' cause.<ref name="WHO20172">{{cite web |title=Plague |url=https://www.who.int/ith/diseases/plague/en/ |archive-url=https://web.archive.org/web/20170319114939/http://www.who.int/ith/diseases/plague/en/ |archive-date=19 March 2017 |access-date=14 March 2017 |website=www.who.int}}</ref> Symptoms dey include [[fever]], headache, [[shortness of breath]], [[chest pain]], coughing, den [[hemoptysis|coughing up blood]].<ref name="CDC20152">{{cite web |title=FAQ Plague |url=https://www.cdc.gov/plague/faq/ |url-status=live |archive-url=https://web.archive.org/web/20170314062829/https://www.cdc.gov/plague/faq/ |archive-date=14 March 2017 |access-date=13 March 2017 |website=www.cdc.gov}}</ref> Dem typically dey start about three to seven days after exposure.<ref name="WHO2016Fact2">{{cite web |date=September 2016 |title=Plague |url=https://www.who.int/mediacentre/factsheets/fs267/en/ |url-status=live |archive-url=https://web.archive.org/web/20150424065540/http://www.who.int/mediacentre/factsheets/fs267/en/ |archive-date=24 April 2015 |access-date=14 March 2017 |website=World Health Organization}}</ref> E be one of three forms of [[Plague (disease)|plague]], de oda two be [[bubonic plague]] den [[septicemic plague]].<ref name="WHO20172" />
De pneumonic form fi occur following an initial bubonic anaa septicemic plague infection.<ref name="WHO20172" /> E sanso fi result from breathing insyd [[airborne disease|airborne]] droplets from anoda person anaa animal infected plus pneumonic plague.<ref name="CDC20152" /> De factor wey dey differ among de three forms of plague be de location of infection; insyd pneumonic plague de infection be insyd de lungs, insyd bubonic plague de [[lymph nodes]], den insyd septicemic plague within de blood.<ref name="WHO20172" /> Diagnosis be by testing de blood, sputum, anaa fluid from a lymph node.<ref name="CDC20152" />
While dem dey develop [[vaccine]]s, insyd most countries dem no yet be commercially available.<ref name="WHO20172" /><ref name="CDC20152" /> Plague be present among rodents insyd [[Africa]], de Americas, den Asia.<ref name="WHO20172" /> Na de total reported number of cases of all types of plague insyd 2013 be 783.<ref name="WHO2016Fact2" />
Pneumonic plague fi be prevented by avoiding contact plus infected people den animals, den by de use of correctly fitted N95 masks.<ref name="WHO20172" /><ref name="CDC20152" /> E be recommended say those infected be [[isolation (health care)|isolated]] from odas.<ref name="WHO2016Fact2" /> Treatment of pneumonic plague dey consist of [[antibiotic]]s.<ref name="CDC20152" />
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
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'''Pneumonic plague''' be a severe [[lung infection]] wey de [[bacterium]] ''[[Yersinia pestis]]'' cause.<ref name="WHO20172">{{cite web |title=Plague |url=https://www.who.int/ith/diseases/plague/en/ |archive-url=https://web.archive.org/web/20170319114939/http://www.who.int/ith/diseases/plague/en/ |archive-date=19 March 2017 |access-date=14 March 2017 |website=www.who.int}}</ref> Symptoms dey include [[fever]], headache, [[shortness of breath]], [[chest pain]], coughing, den [[hemoptysis|coughing up blood]].<ref name="CDC20152">{{cite web |title=FAQ Plague |url=https://www.cdc.gov/plague/faq/ |url-status=live |archive-url=https://web.archive.org/web/20170314062829/https://www.cdc.gov/plague/faq/ |archive-date=14 March 2017 |access-date=13 March 2017 |website=www.cdc.gov}}</ref> Dem typically dey start about three to seven days after exposure.<ref name="WHO2016Fact2">{{cite web |date=September 2016 |title=Plague |url=https://www.who.int/mediacentre/factsheets/fs267/en/ |url-status=live |archive-url=https://web.archive.org/web/20150424065540/http://www.who.int/mediacentre/factsheets/fs267/en/ |archive-date=24 April 2015 |access-date=14 March 2017 |website=World Health Organization}}</ref> E be one of three forms of [[Plague (disease)|plague]], de oda two be [[bubonic plague]] den [[septicemic plague]].<ref name="WHO20172" />
De pneumonic form fi occur following an initial bubonic anaa septicemic plague infection.<ref name="WHO20172" /> E sanso fi result from breathing insyd [[airborne disease|airborne]] droplets from anoda person anaa animal infected plus pneumonic plague.<ref name="CDC20152" /> De factor wey dey differ among de three forms of plague be de location of infection; insyd pneumonic plague de infection be insyd de lungs, insyd bubonic plague de [[lymph nodes]], den insyd septicemic plague within de blood.<ref name="WHO20172" /> Diagnosis be by testing de blood, sputum, anaa fluid from a lymph node.<ref name="CDC20152" />
While dem dey develop [[vaccine]]s, insyd most countries dem no yet be commercially available.<ref name="WHO20172" /><ref name="CDC20152" /> Plague be present among rodents insyd [[Africa]], de Americas, den Asia.<ref name="WHO20172" /> Na de total reported number of cases of all types of plague insyd 2013 be 783.<ref name="WHO2016Fact2" />
Pneumonic plague fi be prevented by avoiding contact plus infected people den animals, den by de use of correctly fitted N95 masks.<ref name="WHO20172" /><ref name="CDC20152" /> E be recommended say those infected be [[isolation (health care)|isolated]] from odas.<ref name="WHO2016Fact2" /> Treatment of pneumonic plague dey consist of [[antibiotic]]s.<ref name="CDC20152" />
Pneumonic plague be more serious den less common dan bubonic plague.<ref name="CDC20152" /> Left untreated, pneumonic plague be almost always fatal.<ref>{{Cite web| title=Plague | url=http://www.cfsph.iastate.edu/Factsheets/pdfs/plague.pdf | archive-url=https://web.archive.org/web/20040917221431/http://www.cfsph.iastate.edu:80/factsheets/pdfs/plague.pdf | archive-date=2004-09-17}}</ref>
Sam hypothesize say na de pneumonic version of de plague be mainly responsible for de [[Black Death]] wey result in approximately 25-50 million deaths insyd [[Europe]] insyd de 1300s.<ref name="WHO2016Fact2" /><ref>{{cite news|last1=McCoy|first1=Terrence|title=Everything you know about the Black Death is wrong|url=https://www.washingtonpost.com/news/morning-mix/wp/2014/03/31/everything-you-know-about-the-black-death-is-wrong-say-the-bones/|access-date=14 March 2017|newspaper=Washington Post|agency=The Washington Post|date=31 March 2014|url-status=live|archive-url=https://web.archive.org/web/20160827172208/https://www.washingtonpost.com/news/morning-mix/wp/2014/03/31/everything-you-know-about-the-black-death-is-wrong-say-the-bones/|archive-date=27 August 2016}}</ref>
== References ==
<references />
== External links ==
[[Category:Translated from MDWiki]]
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{{Databox}}
'''Pneumonic plague''' be a severe [[lung infection]] wey de [[bacterium]] ''[[Yersinia pestis]]'' cause.<ref name="WHO20172">{{cite web |title=Plague |url=https://www.who.int/ith/diseases/plague/en/ |archive-url=https://web.archive.org/web/20170319114939/http://www.who.int/ith/diseases/plague/en/ |archive-date=19 March 2017 |access-date=14 March 2017 |website=www.who.int}}</ref> Symptoms dey include [[fever]], headache, [[shortness of breath]], [[chest pain]], coughing, den [[hemoptysis|coughing up blood]].<ref name="CDC20152">{{cite web |title=FAQ Plague |url=https://www.cdc.gov/plague/faq/ |url-status=live |archive-url=https://web.archive.org/web/20170314062829/https://www.cdc.gov/plague/faq/ |archive-date=14 March 2017 |access-date=13 March 2017 |website=www.cdc.gov}}</ref> Dem typically dey start about three to seven days after exposure.<ref name="WHO2016Fact2">{{cite web |date=September 2016 |title=Plague |url=https://www.who.int/mediacentre/factsheets/fs267/en/ |url-status=live |archive-url=https://web.archive.org/web/20150424065540/http://www.who.int/mediacentre/factsheets/fs267/en/ |archive-date=24 April 2015 |access-date=14 March 2017 |website=World Health Organization}}</ref> E be one of three forms of [[Plague (disease)|plague]], de oda two be [[bubonic plague]] den [[septicemic plague]].<ref name="WHO20172" />
De pneumonic form fi occur following an initial bubonic anaa septicemic plague infection.<ref name="WHO20172" /> E sanso fi result from breathing insyd [[airborne disease|airborne]] droplets from anoda person anaa animal infected plus pneumonic plague.<ref name="CDC20152" /> De factor wey dey differ among de three forms of plague be de location of infection; insyd pneumonic plague de infection be insyd de lungs, insyd bubonic plague de [[lymph nodes]], den insyd septicemic plague within de blood.<ref name="WHO20172" /> Diagnosis be by testing de blood, sputum, anaa fluid from a lymph node.<ref name="CDC20152" />
While dem dey develop [[vaccine]]s, insyd most countries dem no yet be commercially available.<ref name="WHO20172" /><ref name="CDC20152" /> Plague be present among rodents insyd [[Africa]], de Americas, den Asia.<ref name="WHO20172" /> Na de total reported number of cases of all types of plague insyd 2013 be 783.<ref name="WHO2016Fact2" />
Pneumonic plague fi be prevented by avoiding contact plus infected people den animals, den by de use of correctly fitted N95 masks.<ref name="WHO20172" /><ref name="CDC20152" /> E be recommended say those infected be [[isolation (health care)|isolated]] from odas.<ref name="WHO2016Fact2" /> Treatment of pneumonic plague dey consist of [[antibiotic]]s.<ref name="CDC20152" />
Pneumonic plague be more serious den less common dan bubonic plague.<ref name="CDC20152" /> Left untreated, pneumonic plague be almost always fatal.<ref>{{Cite web| title=Plague | url=http://www.cfsph.iastate.edu/Factsheets/pdfs/plague.pdf | archive-url=https://web.archive.org/web/20040917221431/http://www.cfsph.iastate.edu:80/factsheets/pdfs/plague.pdf | archive-date=2004-09-17}}</ref>
Sam hypothesize say na de pneumonic version of de plague be mainly responsible for de [[Black Death]] wey result in approximately 25-50 million deaths insyd [[Europe]] insyd de 1300s.<ref name="WHO2016Fact2" /><ref>{{cite news|last1=McCoy|first1=Terrence|title=Everything you know about the Black Death is wrong|url=https://www.washingtonpost.com/news/morning-mix/wp/2014/03/31/everything-you-know-about-the-black-death-is-wrong-say-the-bones/|access-date=14 March 2017|newspaper=Washington Post|agency=The Washington Post|date=31 March 2014|url-status=live|archive-url=https://web.archive.org/web/20160827172208/https://www.washingtonpost.com/news/morning-mix/wp/2014/03/31/everything-you-know-about-the-black-death-is-wrong-say-the-bones/|archive-date=27 August 2016}}</ref>
== References ==
<references />
== External links ==
{{commons category}}
* [https://www.cdc.gov/plague/faq Frequently Asked Questions | Plague | CDC]. Centers for Disease Control and Prevention.
{{DEFAULTSORT:Pneumonic Plague}}
[[Category:Insect-borne diseases]]
[[Category:Plague (disease)]]
[[Category:Zoonotic bacterial diseases]]
[[Category:Translated from MDWiki]]
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