Wikipedia gpewiki https://gpe.wikipedia.org/wiki/Main_Page MediaWiki 1.47.0-wmf.24 first-letter Media Special Talk User User talk Wikipedia Wikipedia talk File File talk MediaWiki MediaWiki talk Template Template talk Help Help talk Category Category talk TimedText TimedText talk Module Module talk Event Event talk 0 31055 114968 114967 2026-10-17T12:00:58Z DaSupremo 9 Improve article 114968 wikitext text/x-wiki {{Databox}} '''Folate''', dem sanso know as '''vitamin B₉''' den '''folacin''',<ref name="lpi">{{cite web | date = 2023 | title = Folate | website = Linus Pauling Institute | publisher = Micronutrient Information Center, Linus Pauling Institute, Oregon State University | url = https://lpi.oregonstate.edu/mic/vitamins/folate | access-date = 7 September 2025 | quote = Folate is a water-soluble B-vitamin, which is also known as vitamin B9 or folacin }}</ref> be one of de [[B vitamins]].<ref name="NIH2">{{cite web |date=30 November 2022 |title=Folate – Fact Sheet for Health Professionals |url=https://ods.od.nih.gov/factsheets/folate-HealthProfessional/ |access-date=7 September 2025 |publisher=Office of Dietary Supplements, US [[National Institutes of Health]]}}</ref><ref name=AHFS2016>{{cite web|title=Folic Acid|url=https://www.drugs.com/monograph/folic-acid.html|website=Drugs.com|publisher=American Society of Health-System Pharmacists|access-date=7 September 2025|date=23 December 2024}}</ref> Folate be required for de body to make [[DNA]] den [[RNA]] den metabolize [[amino acids]] necessary for [[cell division]] den maturation of [[blood cell]]s.<ref name="NIH2" /><ref name="PKIN2020Folate">{{cite book | vauthors = West AA, Caudill MA, Bailey LB | year = 2020 | veditors = Marriott BP, Birt DF, Stallings VA, Yates AA | chapter = Folate | title = Present Knowledge in Nutrition, Eleventh Edition | location = London, United Kingdom | publisher = Academic Press (Elsevier) | pages = 273–288 | isbn = 978-0-323-66162-1 }}</ref> As de human body no fi make folate, e be required insyd de diet, wey dey make am an [[Nutrient#Essential nutrients|essential nutrient]].<ref>{{cite book | vauthors = Pommerville JC | date = 2009 | title = Alcamo's Fundamentals of Microbiology: Body Systems | publisher = Jones & Bartlett Publishers | page = 511 | isbn = 978-0-7637-8712-7 | url = https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213409/https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | url-status = live }}</ref> E dey occur naturally insyd chaw foods.<ref name="lpi" /><ref name="NIH2" /> De recommended adult daily intake of folate insyd de U.S. be 400 [[microgram]]s from foods anaa [[dietary supplement]]s.<ref name="NIH2" /> Dem manufacture '''folic acid''', wich be converted into folate by de body, be used as a [[dietary supplement]] den insyd [[food fortification]] as e be more stable during processing den storage.<ref name="lpi" /><ref name="NIH2" /> == References == [[Category:Translated from MDWiki]] <references /> == External links == 5imm27wz4h7z6yc0ogjwwgt1okk93gg 114969 114968 2026-10-17T23:11:18Z DaSupremo 9 Improve article 114969 wikitext text/x-wiki {{Databox}} '''Folate''', dem sanso know as '''vitamin B₉''' den '''folacin''',<ref name="lpi">{{cite web | date = 2023 | title = Folate | website = Linus Pauling Institute | publisher = Micronutrient Information Center, Linus Pauling Institute, Oregon State University | url = https://lpi.oregonstate.edu/mic/vitamins/folate | access-date = 7 September 2025 | quote = Folate is a water-soluble B-vitamin, which is also known as vitamin B9 or folacin }}</ref> be one of de [[B vitamins]].<ref name="NIH2">{{cite web |date=30 November 2022 |title=Folate – Fact Sheet for Health Professionals |url=https://ods.od.nih.gov/factsheets/folate-HealthProfessional/ |access-date=7 September 2025 |publisher=Office of Dietary Supplements, US [[National Institutes of Health]]}}</ref><ref name=AHFS2016>{{cite web|title=Folic Acid|url=https://www.drugs.com/monograph/folic-acid.html|website=Drugs.com|publisher=American Society of Health-System Pharmacists|access-date=7 September 2025|date=23 December 2024}}</ref> Folate be required for de body to make [[DNA]] den [[RNA]] den metabolize [[amino acids]] necessary for [[cell division]] den maturation of [[blood cell]]s.<ref name="NIH2" /><ref name="PKIN2020Folate">{{cite book | vauthors = West AA, Caudill MA, Bailey LB | year = 2020 | veditors = Marriott BP, Birt DF, Stallings VA, Yates AA | chapter = Folate | title = Present Knowledge in Nutrition, Eleventh Edition | location = London, United Kingdom | publisher = Academic Press (Elsevier) | pages = 273–288 | isbn = 978-0-323-66162-1 }}</ref> As de human body no fi make folate, e be required insyd de diet, wey dey make am an [[Nutrient#Essential nutrients|essential nutrient]].<ref>{{cite book | vauthors = Pommerville JC | date = 2009 | title = Alcamo's Fundamentals of Microbiology: Body Systems | publisher = Jones & Bartlett Publishers | page = 511 | isbn = 978-0-7637-8712-7 | url = https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213409/https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | url-status = live }}</ref> E dey occur naturally insyd chaw foods.<ref name="lpi" /><ref name="NIH2" /> De recommended adult daily intake of folate insyd de U.S. be 400 [[microgram]]s from foods anaa [[dietary supplement]]s.<ref name="NIH2" /> Dem manufacture '''folic acid''', wich be converted into folate by de body, be used as a [[dietary supplement]] den insyd [[food fortification]] as e be more stable during processing den storage.<ref name="lpi" /><ref name="NIH2" /> Folate insyd de form of folic acid be used to treat [[anemia]] wey be caused by [[folic acid deficiency|folate deficiency]].<ref name="AHFS2016" /> Folic acid sanso be used as a supplement by women during [[pregnancy]] to reduce de risk of [[neural tube defect]]s (NTDs) insyd de baby.<ref name="AHFS2016" /><ref>{{cite journal | vauthors = Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, Epling JW, García FA, Kemper AR, Krist AH, Kurth AE, Landefeld CS, Mangione CM, Phillips WR, Phipps MG, Pignone MP, Silverstein M, Tseng CW | title = Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement | journal = JAMA | volume = 317 | issue = 2 | pages = 183–189 | date = January 2017 | pmid = 28097362 | doi = 10.1001/jama.2016.19438 | s2cid = 205077749 }}</ref> NTDs dey include [[anencephaly]] den [[spina bifida]], among oda defects. Low levels insyd early pregnancy be believed to be de cause of more dan half of babies born plus NTDs. More dan 80 countries dey use either mandatory anaa voluntary fortification of certain foods plus folic acid as a measure to decrease de rate of NTDs. Long-term supplementation plus relatively large amounts of folic acid be associated plus a small reduction in de risk of [[stroke]] den, for "relatively large amount" wey dey mean ≥ 400 μg/day, an increased risk of prostate cancer.<ref name="Wien2012">{{cite journal|vauthors=Wien TN, Pike E, Wisløff T, Staff A, Smeland S, Klemp M|title=Cancer risk with folic acid supplements: a systematic review and meta-analysis|journal=BMJ Open|volume=2|issue=1|article-number=e000653|date=January 2012|pmid=22240654|pmc=3278486|doi=10.1136/bmjopen-2011-000653|doi-access=free}}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] tnxxf3iwg594slmviy07u6hy082es3s 114970 114969 2026-10-17T23:15:57Z DaSupremo 9 Add references 114970 wikitext text/x-wiki {{Databox}} '''Folate''', dem sanso know as '''vitamin B₉''' den '''folacin''',<ref name="lpi">{{cite web | date = 2023 | title = Folate | website = Linus Pauling Institute | publisher = Micronutrient Information Center, Linus Pauling Institute, Oregon State University | url = https://lpi.oregonstate.edu/mic/vitamins/folate | access-date = 7 September 2025 | quote = Folate is a water-soluble B-vitamin, which is also known as vitamin B9 or folacin }}</ref> be one of de [[B vitamins]].<ref name="NIH2">{{cite web |date=30 November 2022 |title=Folate – Fact Sheet for Health Professionals |url=https://ods.od.nih.gov/factsheets/folate-HealthProfessional/ |access-date=7 September 2025 |publisher=Office of Dietary Supplements, US [[National Institutes of Health]]}}</ref><ref name=AHFS2016>{{cite web|title=Folic Acid|url=https://www.drugs.com/monograph/folic-acid.html|website=Drugs.com|publisher=American Society of Health-System Pharmacists|access-date=7 September 2025|date=23 December 2024}}</ref> Folate be required for de body to make [[DNA]] den [[RNA]] den metabolize [[amino acids]] necessary for [[cell division]] den maturation of [[blood cell]]s.<ref name="NIH2" /><ref name="PKIN2020Folate">{{cite book | vauthors = West AA, Caudill MA, Bailey LB | year = 2020 | veditors = Marriott BP, Birt DF, Stallings VA, Yates AA | chapter = Folate | title = Present Knowledge in Nutrition, Eleventh Edition | location = London, United Kingdom | publisher = Academic Press (Elsevier) | pages = 273–288 | isbn = 978-0-323-66162-1 }}</ref> As de human body no fi make folate, e be required insyd de diet, wey dey make am an [[Nutrient#Essential nutrients|essential nutrient]].<ref>{{cite book | vauthors = Pommerville JC | date = 2009 | title = Alcamo's Fundamentals of Microbiology: Body Systems | publisher = Jones & Bartlett Publishers | page = 511 | isbn = 978-0-7637-8712-7 | url = https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213409/https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | url-status = live }}</ref> E dey occur naturally insyd chaw foods.<ref name="lpi" /><ref name="NIH2" /> De recommended adult daily intake of folate insyd de U.S. be 400 [[microgram]]s from foods anaa [[dietary supplement]]s.<ref name="NIH2" /> Dem manufacture '''folic acid''', wich be converted into folate by de body, be used as a dietary supplement den insyd [[food fortification]] as e be more stable during processing den storage.<ref name="lpi" /><ref name="NIH2" /> Folate insyd de form of folic acid be used to treat [[anemia]] wey be caused by [[folic acid deficiency|folate deficiency]].<ref name="AHFS2016" /> Folic acid sanso be used as a supplement by women during [[pregnancy]] to reduce de risk of [[neural tube defect]]s (NTDs) insyd de baby.<ref name="AHFS2016" /><ref>{{cite journal | vauthors = Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, Epling JW, García FA, Kemper AR, Krist AH, Kurth AE, Landefeld CS, Mangione CM, Phillips WR, Phipps MG, Pignone MP, Silverstein M, Tseng CW | title = Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement | journal = JAMA | volume = 317 | issue = 2 | pages = 183–189 | date = January 2017 | pmid = 28097362 | doi = 10.1001/jama.2016.19438 | s2cid = 205077749 }}</ref> NTDs dey include [[anencephaly]] den [[spina bifida]], among oda defects. Low levels insyd early pregnancy be believed to be de cause of more dan half of babies born plus NTDs.<ref name="NIH2" /> More dan 80 countries dey use either mandatory anaa voluntary fortification of certain foods plus folic acid as a measure to decrease de rate of NTDs.<ref name="Wald2018">{{cite journal |vauthors=Wald NJ, Morris JK, Blakemore C |date=2018 |title=Public health failure in the prevention of neural tube defects: time to abandon the tolerable upper intake level of folate |journal=Public Health Reviews |volume=39 |doi=10.1186/s40985-018-0079-6 |pmc=5809909 |pmid=29450103 |doi-access=free |article-number=2}}</ref> Long-term supplementation plus relatively large amounts of folic acid be associated plus a small reduction in de risk of [[stroke]]<ref name="Li2016">{{cite journal |vauthors=Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB |date=August 2016 |title=Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials |url=https://dash.harvard.edu/bitstream/handle/1/29407892/5015297.pdf?sequence=1 |url-status=live |journal=Journal of the American Heart Association |volume=5 |issue=8 |doi=10.1161/JAHA.116.003768 |pmc=5015297 |pmid=27528407 |archive-url=https://web.archive.org/web/20210427034202/https://dash.harvard.edu/bitstream/handle/1/29407892/5015297.pdf?sequence=1 |archive-date=27 April 2021 |access-date=4 November 2018 |doi-access=free |article-number=e003768}}</ref> den, for "relatively large amount" wey dey mean ≥ 400 μg/day, an increased risk of prostate cancer.<ref name="Wien2012">{{cite journal|vauthors=Wien TN, Pike E, Wisløff T, Staff A, Smeland S, Klemp M|title=Cancer risk with folic acid supplements: a systematic review and meta-analysis|journal=BMJ Open|volume=2|issue=1|article-number=e000653|date=January 2012|pmid=22240654|pmc=3278486|doi=10.1136/bmjopen-2011-000653|doi-access=free}}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] didptmfmwmp17eb7pfegvftx1ikf9hd 114971 114970 2026-10-17T23:48:13Z DaSupremo 9 Improve article 114971 wikitext text/x-wiki {{Databox}} '''Folate''', dem sanso know as '''vitamin B₉''' den '''folacin''',<ref name="lpi">{{cite web | date = 2023 | title = Folate | website = Linus Pauling Institute | publisher = Micronutrient Information Center, Linus Pauling Institute, Oregon State University | url = https://lpi.oregonstate.edu/mic/vitamins/folate | access-date = 7 September 2025 | quote = Folate is a water-soluble B-vitamin, which is also known as vitamin B9 or folacin }}</ref> be one of de [[B vitamins]].<ref name="NIH2">{{cite web |date=30 November 2022 |title=Folate – Fact Sheet for Health Professionals |url=https://ods.od.nih.gov/factsheets/folate-HealthProfessional/ |access-date=7 September 2025 |publisher=Office of Dietary Supplements, US [[National Institutes of Health]]}}</ref><ref name=AHFS2016>{{cite web|title=Folic Acid|url=https://www.drugs.com/monograph/folic-acid.html|website=Drugs.com|publisher=American Society of Health-System Pharmacists|access-date=7 September 2025|date=23 December 2024}}</ref> Folate be required for de body to make [[DNA]] den [[RNA]] den metabolize [[amino acids]] necessary for [[cell division]] den maturation of [[blood cell]]s.<ref name="NIH2" /><ref name="PKIN2020Folate">{{cite book | vauthors = West AA, Caudill MA, Bailey LB | year = 2020 | veditors = Marriott BP, Birt DF, Stallings VA, Yates AA | chapter = Folate | title = Present Knowledge in Nutrition, Eleventh Edition | location = London, United Kingdom | publisher = Academic Press (Elsevier) | pages = 273–288 | isbn = 978-0-323-66162-1 }}</ref> As de human body no fi make folate, e be required insyd de diet, wey dey make am an [[Nutrient#Essential nutrients|essential nutrient]].<ref>{{cite book | vauthors = Pommerville JC | date = 2009 | title = Alcamo's Fundamentals of Microbiology: Body Systems | publisher = Jones & Bartlett Publishers | page = 511 | isbn = 978-0-7637-8712-7 | url = https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213409/https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | url-status = live }}</ref> E dey occur naturally insyd chaw foods.<ref name="lpi" /><ref name="NIH2" /> De recommended adult daily intake of folate insyd de U.S. be 400 [[microgram]]s from foods anaa [[dietary supplement]]s.<ref name="NIH2" /> Dem manufacture '''folic acid''', wich be converted into folate by de body, be used as a dietary supplement den insyd [[food fortification]] as e be more stable during processing den storage.<ref name="lpi" /><ref name="NIH2" /> Folate insyd de form of folic acid be used to treat [[anemia]] wey be caused by [[folic acid deficiency|folate deficiency]].<ref name="AHFS2016" /> Folic acid sanso be used as a supplement by women during [[pregnancy]] to reduce de risk of [[neural tube defect]]s (NTDs) insyd de baby.<ref name="AHFS2016" /><ref>{{cite journal | vauthors = Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, Epling JW, García FA, Kemper AR, Krist AH, Kurth AE, Landefeld CS, Mangione CM, Phillips WR, Phipps MG, Pignone MP, Silverstein M, Tseng CW | title = Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement | journal = JAMA | volume = 317 | issue = 2 | pages = 183–189 | date = January 2017 | pmid = 28097362 | doi = 10.1001/jama.2016.19438 | s2cid = 205077749 }}</ref> NTDs dey include [[anencephaly]] den [[spina bifida]], among oda defects. Low levels insyd early pregnancy be believed to be de cause of more dan half of babies born plus NTDs.<ref name="NIH2" /> More dan 80 countries dey use either mandatory anaa voluntary fortification of certain foods plus folic acid as a measure to decrease de rate of NTDs.<ref name="Wald2018">{{cite journal |vauthors=Wald NJ, Morris JK, Blakemore C |date=2018 |title=Public health failure in the prevention of neural tube defects: time to abandon the tolerable upper intake level of folate |journal=Public Health Reviews |volume=39 |doi=10.1186/s40985-018-0079-6 |pmc=5809909 |pmid=29450103 |doi-access=free |article-number=2}}</ref> Long-term supplementation plus relatively large amounts of folic acid be associated plus a small reduction in de risk of [[stroke]]<ref name="Li2016">{{cite journal |vauthors=Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB |date=August 2016 |title=Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials |url=https://dash.harvard.edu/bitstream/handle/1/29407892/5015297.pdf?sequence=1 |url-status=live |journal=Journal of the American Heart Association |volume=5 |issue=8 |doi=10.1161/JAHA.116.003768 |pmc=5015297 |pmid=27528407 |archive-url=https://web.archive.org/web/20210427034202/https://dash.harvard.edu/bitstream/handle/1/29407892/5015297.pdf?sequence=1 |archive-date=27 April 2021 |access-date=4 November 2018 |doi-access=free |article-number=e003768}}</ref> den, for "relatively large amount" wey dey mean ≥ 400 μg/day, an increased risk of prostate cancer.<ref name="Wien2012">{{cite journal|vauthors=Wien TN, Pike E, Wisløff T, Staff A, Smeland S, Klemp M|title=Cancer risk with folic acid supplements: a systematic review and meta-analysis|journal=BMJ Open|volume=2|issue=1|article-number=e000653|date=January 2012|pmid=22240654|pmc=3278486|doi=10.1136/bmjopen-2011-000653|doi-access=free}}</ref> No dey consume enough folate fi lead to folate deficiency.<ref name="NIH2" /> Dis fi result in [[megaloblastic anemia|a type of anemia]] insyd wich red blood cells cam be abnormally large.<ref name="NIH2" /> Symptoms fi include [[fatigue (medical)|feeling tired]], [[heart palpitations]], [[shortness of breath]], open sores on de tongue, den changes insyd de color of de skin anaa hair.<ref name="NIH2" /> Folate deficiency insyd kiddies fi develop within a month of poor dietary intake.<ref>{{cite book | vauthors = Marino BS, Fine KS | date = 2009 | title = Blueprints Pediatrics | publisher = Lippincott Williams & Wilkins | page = 131 | isbn = 978-0-7817-8251-7 | url = https://books.google.com/books?id=oqpSRIOcd8MC&pg=PA131 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213408/https://books.google.com/books?id=oqpSRIOcd8MC&pg=PA131 | url-status = live }}</ref> Insyd adults, normal total body folate be between 10 den 30&nbsp;mg plus about half of dis amount stored insyd de liver den de remainder insyd blood den body tissues.<ref name="NIH2" /> Insyd plasma, de natural folate range be 150 to 450&nbsp;nM.<ref>{{cite journal | vauthors = Fardous AM, Heydari AR | title = Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review | journal = Nutrients | volume = 15 | issue = 21 | page = 4699 | date = November 2023 | pmid = 37960352 | pmc = 10648405 | doi = 10.3390/nu15214699 | doi-access = free }}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] mmmucatahjqpyq0g7028ypei8z9ga95 114972 114971 2026-10-17T23:56:54Z DaSupremo 9 Improve article 114972 wikitext text/x-wiki {{Databox}} '''Folate''', dem sanso know as '''vitamin B₉''' den '''folacin''',<ref name="lpi">{{cite web | date = 2023 | title = Folate | website = Linus Pauling Institute | publisher = Micronutrient Information Center, Linus Pauling Institute, Oregon State University | url = https://lpi.oregonstate.edu/mic/vitamins/folate | access-date = 7 September 2025 | quote = Folate is a water-soluble B-vitamin, which is also known as vitamin B9 or folacin }}</ref> be one of de [[B vitamins]].<ref name="NIH2">{{cite web |date=30 November 2022 |title=Folate – Fact Sheet for Health Professionals |url=https://ods.od.nih.gov/factsheets/folate-HealthProfessional/ |access-date=7 September 2025 |publisher=Office of Dietary Supplements, US [[National Institutes of Health]]}}</ref><ref name=AHFS2016>{{cite web|title=Folic Acid|url=https://www.drugs.com/monograph/folic-acid.html|website=Drugs.com|publisher=American Society of Health-System Pharmacists|access-date=7 September 2025|date=23 December 2024}}</ref> Folate be required for de body to make [[DNA]] den [[RNA]] den metabolize [[amino acids]] necessary for [[cell division]] den maturation of [[blood cell]]s.<ref name="NIH2" /><ref name="PKIN2020Folate">{{cite book | vauthors = West AA, Caudill MA, Bailey LB | year = 2020 | veditors = Marriott BP, Birt DF, Stallings VA, Yates AA | chapter = Folate | title = Present Knowledge in Nutrition, Eleventh Edition | location = London, United Kingdom | publisher = Academic Press (Elsevier) | pages = 273–288 | isbn = 978-0-323-66162-1 }}</ref> As de human body no fi make folate, e be required insyd de diet, wey dey make am an [[Nutrient#Essential nutrients|essential nutrient]].<ref>{{cite book | vauthors = Pommerville JC | date = 2009 | title = Alcamo's Fundamentals of Microbiology: Body Systems | publisher = Jones & Bartlett Publishers | page = 511 | isbn = 978-0-7637-8712-7 | url = https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213409/https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | url-status = live }}</ref> E dey occur naturally insyd chaw foods.<ref name="lpi" /><ref name="NIH2" /> De recommended adult daily intake of folate insyd de U.S. be 400 [[microgram]]s from foods anaa [[dietary supplement]]s.<ref name="NIH2" /> Dem manufacture '''folic acid''', wich be converted into folate by de body, be used as a dietary supplement den insyd [[food fortification]] as e be more stable during processing den storage.<ref name="lpi" /><ref name="NIH2" /> Folate insyd de form of folic acid be used to treat [[anemia]] wey be caused by [[folic acid deficiency|folate deficiency]].<ref name="AHFS2016" /> Folic acid sanso be used as a supplement by women during [[pregnancy]] to reduce de risk of [[neural tube defect]]s (NTDs) insyd de baby.<ref name="AHFS2016" /><ref>{{cite journal | vauthors = Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, Epling JW, García FA, Kemper AR, Krist AH, Kurth AE, Landefeld CS, Mangione CM, Phillips WR, Phipps MG, Pignone MP, Silverstein M, Tseng CW | title = Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement | journal = JAMA | volume = 317 | issue = 2 | pages = 183–189 | date = January 2017 | pmid = 28097362 | doi = 10.1001/jama.2016.19438 | s2cid = 205077749 }}</ref> NTDs dey include [[anencephaly]] den [[spina bifida]], among oda defects. Low levels insyd early pregnancy be believed to be de cause of more dan half of babies born plus NTDs.<ref name="NIH2" /> More dan 80 countries dey use either mandatory anaa voluntary fortification of certain foods plus folic acid as a measure to decrease de rate of NTDs.<ref name="Wald2018">{{cite journal |vauthors=Wald NJ, Morris JK, Blakemore C |date=2018 |title=Public health failure in the prevention of neural tube defects: time to abandon the tolerable upper intake level of folate |journal=Public Health Reviews |volume=39 |doi=10.1186/s40985-018-0079-6 |pmc=5809909 |pmid=29450103 |doi-access=free |article-number=2}}</ref> Long-term supplementation plus relatively large amounts of folic acid be associated plus a small reduction in de risk of [[stroke]]<ref name="Li2016">{{cite journal |vauthors=Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB |date=August 2016 |title=Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials |url=https://dash.harvard.edu/bitstream/handle/1/29407892/5015297.pdf?sequence=1 |url-status=live |journal=Journal of the American Heart Association |volume=5 |issue=8 |doi=10.1161/JAHA.116.003768 |pmc=5015297 |pmid=27528407 |archive-url=https://web.archive.org/web/20210427034202/https://dash.harvard.edu/bitstream/handle/1/29407892/5015297.pdf?sequence=1 |archive-date=27 April 2021 |access-date=4 November 2018 |doi-access=free |article-number=e003768}}</ref> den, for "relatively large amount" wey dey mean ≥ 400 μg/day, an increased risk of prostate cancer.<ref name="Wien2012">{{cite journal|vauthors=Wien TN, Pike E, Wisløff T, Staff A, Smeland S, Klemp M|title=Cancer risk with folic acid supplements: a systematic review and meta-analysis|journal=BMJ Open|volume=2|issue=1|article-number=e000653|date=January 2012|pmid=22240654|pmc=3278486|doi=10.1136/bmjopen-2011-000653|doi-access=free}}</ref> No dey consume enough folate fi lead to folate deficiency.<ref name="NIH2" /> Dis fi result in [[megaloblastic anemia|a type of anemia]] insyd wich red blood cells cam be abnormally large.<ref name="NIH2" /> Symptoms fi include [[fatigue (medical)|feeling tired]], [[heart palpitations]], [[shortness of breath]], open sores on de tongue, den changes insyd de color of de skin anaa hair.<ref name="NIH2" /> Folate deficiency insyd kiddies fi develop within a month of poor dietary intake.<ref>{{cite book | vauthors = Marino BS, Fine KS | date = 2009 | title = Blueprints Pediatrics | publisher = Lippincott Williams & Wilkins | page = 131 | isbn = 978-0-7817-8251-7 | url = https://books.google.com/books?id=oqpSRIOcd8MC&pg=PA131 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213408/https://books.google.com/books?id=oqpSRIOcd8MC&pg=PA131 | url-status = live }}</ref> Insyd adults, normal total body folate be between 10 den 30&nbsp;mg plus about half of dis amount stored insyd de liver den de remainder insyd blood den body tissues.<ref name="NIH2" /> Insyd plasma, de natural folate range be 150 to 450&nbsp;nM.<ref>{{cite journal | vauthors = Fardous AM, Heydari AR | title = Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review | journal = Nutrients | volume = 15 | issue = 21 | page = 4699 | date = November 2023 | pmid = 37960352 | pmc = 10648405 | doi = 10.3390/nu15214699 | doi-access = free }}</ref> Na dem discover folate between 1931 den 1943.<ref name=Pond>{{cite book | vauthors = Pond WG, Nichols BL, Brown DL | date = 2009 | title = Adequate Food for All: Culture, Science, and Technology of Food in the 21st Century | publisher = CRC Press | page = 148 | isbn = 978-1-4200-7754-4 | url = https://books.google.com/books?id=wbS5FogT1-4C&pg=PA148 | quote = Folic acid's discovery started in 1931... }}</ref> E dey on de [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].<ref name="WHO21st">{{cite book | vauthors = ((World Health Organization)) | year = 2019 | title = World Health Organization model list of essential medicines: 21st list 2019 | location = Geneva | publisher = World Health Organization | hdl = 10665/325771 | author-link = World Health Organization | id = WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO | hdl-access = free }}</ref> Insyd 2023, na e be de 94th most commonly prescribed medication insyd de United States, plus more dan 7{{nbsp}}million prescriptions.<ref name="Top300Drugs">{{cite web | vauthors = Kane SP | title = Top 300 of 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Top300Drugs.aspx | access-date = 12 August 2025 | archive-date = 12 August 2025 | archive-url = https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status = live }}</ref><ref>{{cite web | vauthors = Kane SP | title = Folic Acid Drug Usage Statistics, United States, 2014 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/FolicAcid | access-date = 18 August 2025 }}</ref> De term "folic" be from de Latin word {{lang|la|[[wikt:folium|folium]]}} (wich dey mean leaf) secof na e be found insyd dark-green leafy vegetables.<ref name=Chambers>{{cite book | date = 2004 | title = Chambers Concise Dictionary | publisher = Allied Publishers | page = 451 | isbn = 978-81-86062-36-4 | url = https://books.google.com/books?id=iwWuY9tAVq8C&pg=PA451 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213408/https://books.google.com/books?id=iwWuY9tAVq8C&pg=PA451 | url-status = live }}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] k47ylc69te8ynommckne6o6pahu3hh0 114973 114972 2026-10-17T23:59:52Z DaSupremo 9 Improve article 114973 wikitext text/x-wiki {{Databox}} '''Folate''', dem sanso know as '''vitamin B₉''' den '''folacin''',<ref name="lpi">{{cite web | date = 2023 | title = Folate | website = Linus Pauling Institute | publisher = Micronutrient Information Center, Linus Pauling Institute, Oregon State University | url = https://lpi.oregonstate.edu/mic/vitamins/folate | access-date = 7 September 2025 | quote = Folate is a water-soluble B-vitamin, which is also known as vitamin B9 or folacin }}</ref> be one of de [[B vitamins]].<ref name="NIH2">{{cite web |date=30 November 2022 |title=Folate – Fact Sheet for Health Professionals |url=https://ods.od.nih.gov/factsheets/folate-HealthProfessional/ |access-date=7 September 2025 |publisher=Office of Dietary Supplements, US [[National Institutes of Health]]}}</ref><ref name=AHFS2016>{{cite web|title=Folic Acid|url=https://www.drugs.com/monograph/folic-acid.html|website=Drugs.com|publisher=American Society of Health-System Pharmacists|access-date=7 September 2025|date=23 December 2024}}</ref> Folate be required for de body to make [[DNA]] den [[RNA]] den metabolize [[amino acids]] necessary for [[cell division]] den maturation of [[blood cell]]s.<ref name="NIH2" /><ref name="PKIN2020Folate">{{cite book | vauthors = West AA, Caudill MA, Bailey LB | year = 2020 | veditors = Marriott BP, Birt DF, Stallings VA, Yates AA | chapter = Folate | title = Present Knowledge in Nutrition, Eleventh Edition | location = London, United Kingdom | publisher = Academic Press (Elsevier) | pages = 273–288 | isbn = 978-0-323-66162-1 }}</ref> As de human body no fi make folate, e be required insyd de diet, wey dey make am an [[Nutrient#Essential nutrients|essential nutrient]].<ref>{{cite book | vauthors = Pommerville JC | date = 2009 | title = Alcamo's Fundamentals of Microbiology: Body Systems | publisher = Jones & Bartlett Publishers | page = 511 | isbn = 978-0-7637-8712-7 | url = https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213409/https://books.google.com/books?id=fedRNr2-UVAC&pg=PA551 | url-status = live }}</ref> E dey occur naturally insyd chaw foods.<ref name="lpi" /><ref name="NIH2" /> De recommended adult daily intake of folate insyd de U.S. be 400 [[microgram]]s from foods anaa [[dietary supplement]]s.<ref name="NIH2" /> Dem manufacture '''folic acid''', wich be converted into folate by de body, be used as a dietary supplement den insyd [[food fortification]] as e be more stable during processing den storage.<ref name="lpi" /><ref name="NIH2" /> Folate insyd de form of folic acid be used to treat [[anemia]] wey be caused by [[folic acid deficiency|folate deficiency]].<ref name="AHFS2016" /> Folic acid sanso be used as a supplement by women during [[pregnancy]] to reduce de risk of [[neural tube defect]]s (NTDs) insyd de baby.<ref name="AHFS2016" /><ref>{{cite journal | vauthors = Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, Epling JW, García FA, Kemper AR, Krist AH, Kurth AE, Landefeld CS, Mangione CM, Phillips WR, Phipps MG, Pignone MP, Silverstein M, Tseng CW | title = Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement | journal = JAMA | volume = 317 | issue = 2 | pages = 183–189 | date = January 2017 | pmid = 28097362 | doi = 10.1001/jama.2016.19438 | s2cid = 205077749 }}</ref> NTDs dey include [[anencephaly]] den [[spina bifida]], among oda defects. Low levels insyd early pregnancy be believed to be de cause of more dan half of babies born plus NTDs.<ref name="NIH2" /> More dan 80 countries dey use either mandatory anaa voluntary fortification of certain foods plus folic acid as a measure to decrease de rate of NTDs.<ref name="Wald2018">{{cite journal |vauthors=Wald NJ, Morris JK, Blakemore C |date=2018 |title=Public health failure in the prevention of neural tube defects: time to abandon the tolerable upper intake level of folate |journal=Public Health Reviews |volume=39 |doi=10.1186/s40985-018-0079-6 |pmc=5809909 |pmid=29450103 |doi-access=free |article-number=2}}</ref> Long-term supplementation plus relatively large amounts of folic acid be associated plus a small reduction in de risk of [[stroke]]<ref name="Li2016">{{cite journal |vauthors=Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB |date=August 2016 |title=Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials |url=https://dash.harvard.edu/bitstream/handle/1/29407892/5015297.pdf?sequence=1 |url-status=live |journal=Journal of the American Heart Association |volume=5 |issue=8 |doi=10.1161/JAHA.116.003768 |pmc=5015297 |pmid=27528407 |archive-url=https://web.archive.org/web/20210427034202/https://dash.harvard.edu/bitstream/handle/1/29407892/5015297.pdf?sequence=1 |archive-date=27 April 2021 |access-date=4 November 2018 |doi-access=free |article-number=e003768}}</ref> den, for "relatively large amount" wey dey mean ≥ 400 μg/day, an increased risk of prostate cancer.<ref name="Wien2012">{{cite journal|vauthors=Wien TN, Pike E, Wisløff T, Staff A, Smeland S, Klemp M|title=Cancer risk with folic acid supplements: a systematic review and meta-analysis|journal=BMJ Open|volume=2|issue=1|article-number=e000653|date=January 2012|pmid=22240654|pmc=3278486|doi=10.1136/bmjopen-2011-000653|doi-access=free}}</ref> No dey consume enough folate fi lead to folate deficiency.<ref name="NIH2" /> Dis fi result in [[megaloblastic anemia|a type of anemia]] insyd wich red blood cells cam be abnormally large.<ref name="NIH2" /> Symptoms fi include [[fatigue (medical)|feeling tired]], [[heart palpitations]], [[shortness of breath]], open sores on de tongue, den changes insyd de color of de skin anaa hair.<ref name="NIH2" /> Folate deficiency insyd kiddies fi develop within a month of poor dietary intake.<ref>{{cite book | vauthors = Marino BS, Fine KS | date = 2009 | title = Blueprints Pediatrics | publisher = Lippincott Williams & Wilkins | page = 131 | isbn = 978-0-7817-8251-7 | url = https://books.google.com/books?id=oqpSRIOcd8MC&pg=PA131 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213408/https://books.google.com/books?id=oqpSRIOcd8MC&pg=PA131 | url-status = live }}</ref> Insyd adults, normal total body folate be between 10 den 30&nbsp;mg plus about half of dis amount stored insyd de liver den de remainder insyd blood den body tissues.<ref name="NIH2" /> Insyd plasma, de natural folate range be 150 to 450&nbsp;nM.<ref>{{cite journal | vauthors = Fardous AM, Heydari AR | title = Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review | journal = Nutrients | volume = 15 | issue = 21 | page = 4699 | date = November 2023 | pmid = 37960352 | pmc = 10648405 | doi = 10.3390/nu15214699 | doi-access = free }}</ref> Na dem discover folate between 1931 den 1943.<ref name=Pond>{{cite book | vauthors = Pond WG, Nichols BL, Brown DL | date = 2009 | title = Adequate Food for All: Culture, Science, and Technology of Food in the 21st Century | publisher = CRC Press | page = 148 | isbn = 978-1-4200-7754-4 | url = https://books.google.com/books?id=wbS5FogT1-4C&pg=PA148 | quote = Folic acid's discovery started in 1931... }}</ref> E dey on de [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].<ref name="WHO21st">{{cite book | vauthors = ((World Health Organization)) | year = 2019 | title = World Health Organization model list of essential medicines: 21st list 2019 | location = Geneva | publisher = World Health Organization | hdl = 10665/325771 | author-link = World Health Organization | id = WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO | hdl-access = free }}</ref> Insyd 2023, na e be de 94th most commonly prescribed medication insyd de United States, plus more dan 7{{nbsp}}million prescriptions.<ref name="Top300Drugs">{{cite web | vauthors = Kane SP | title = Top 300 of 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Top300Drugs.aspx | access-date = 12 August 2025 | archive-date = 12 August 2025 | archive-url = https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status = live }}</ref><ref>{{cite web | vauthors = Kane SP | title = Folic Acid Drug Usage Statistics, United States, 2014 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/FolicAcid | access-date = 18 August 2025 }}</ref> De term "folic" be from de Latin word {{lang|la|[[wikt:folium|folium]]}} (wich dey mean leaf) secof na e be found insyd dark-green leafy vegetables.<ref name=Chambers>{{cite book | date = 2004 | title = Chambers Concise Dictionary | publisher = Allied Publishers | page = 451 | isbn = 978-81-86062-36-4 | url = https://books.google.com/books?id=iwWuY9tAVq8C&pg=PA451 | archive-date = 8 September 2017 | archive-url = https://web.archive.org/web/20170908213408/https://books.google.com/books?id=iwWuY9tAVq8C&pg=PA451 | url-status = live }}</ref> == References == <references /> == External links == {{Commons}} Current versions from de [[International Union of Biochemistry and Molecular Biology]]'s ''Recommendations on Biochemical & Organic Nomenclature, Symbols & Terminology etc.'' [https://web.archive.org/web/20170804052444/http://iubmb.qmul.ac.uk/enzyme/reaction/misc/ Enzyme Nomenclature, Miscellaneous Reaction Schemes] section ''Pterins, Riboflavins, etc.'' formerly hosted by [[Queen Mary College]] (all archived by [[archive.org]]): * [https://iubmb.qmul.ac.uk/enzyme/reaction/misc/folate1.html Folate biosynthesis (early stages)] * [https://iubmb.qmul.ac.uk/enzyme/reaction/misc/folate2.html Folate biosynthesis (later stages)] * [https://iubmb.qmul.ac.uk/enzyme/reaction/misc/folate3.html Folate coenzymes] * [https://iubmb.qmul.ac.uk/enzyme/reaction/misc/folate4.html Formylation, hydroxymethylation and methylation using folate] * [https://iubmb.qmul.ac.uk/enzyme/reaction/misc/folate5.html C₁ metabolism with folate] {{DEFAULTSORT:Folic Acid}} [[Category:Folates| ]] [[Category:B vitamins]] [[Category:Dicarboxylic acids]] [[Category:World Health Organization essential medicines]] [[Category:Translated from MDWiki]] ae5j143ime0yp6qjvzuhzp29chuwv11 14 31056 114974 2026-10-18T00:00:24Z DaSupremo 9 Fresh category 114974 wikitext text/x-wiki phoiac9h4m842xq45sp7s6u21eteeq1 0 31057 114975 2026-10-18T10:44:43Z DaSupremo 9 Created by translating the page [[:mdwiki:Special:Redirect/revision/1501636|Disseminated_intravascular_coagulation]] to:gpe #mdwikicx 114975 wikitext text/x-wiki [[Category:Translated from MDWiki]] r0gf7axtnvt68k0p85plnlehx64o08u 114976 114975 2026-10-18T11:26:06Z DaSupremo 9 Improve article 114976 wikitext text/x-wiki {{Databox}} '''Disseminated intravascular coagulation''' ('''DIC''') be a condition insyd wich [[blood clot]]s form thru out de body, blocking [[Microvessel|small blood vessels]].<ref name=nih/> Symptoms fi include [[chest pain]], [[shortness of breath]], leg pain, problems speaking, anaa problems moving parts of de body.<ref name=nih/> As [[clotting factors]] den [[platelet]]s be used up, [[bleeding]] fi occur.<ref name="nih">{{cite web|title=What Are Blood Clotting Disorders? |url=https://www.nhlbi.nih.gov/health/clotting-disorders |publisher=National Heart Lung and Blood Institute, US National Institutes of Health |access-date=9 September 2026|date=2026}}</ref> Dis fi include [[hematuria|blood insyd de urine]], [[GI bleed|blood insyd de stool]], anaa bleeding into de skin.<ref name=nih/> Complications fi include [[organ failure]].<ref name="Mer20162">{{cite web |date=September 2016 |title=Disseminated Intravascular Coagulation (DIC) - Hematology and Oncology |url=https://www.merckmanuals.com/en-ca/professional/hematology-and-oncology/coagulation-disorders/disseminated-intravascular-coagulation-dic |access-date=20 December 2017 |website=Merck Manuals Professional Edition |language=en-CA}}</ref> == References == [[Category:Translated from MDWiki]] <references /> == External links == cio5seey7hndbo7isbaids37gpextk6 114977 114976 2026-10-18T11:58:49Z DaSupremo 9 Improve article 114977 wikitext text/x-wiki {{Databox}} '''Disseminated intravascular coagulation''' ('''DIC''') be a condition insyd wich [[blood clot]]s form thru out de body, blocking [[Microvessel|small blood vessels]].<ref name=nih/> Symptoms fi include [[chest pain]], [[shortness of breath]], leg pain, problems speaking, anaa problems moving parts of de body.<ref name=nih/> As [[clotting factors]] den [[platelet]]s be used up, [[bleeding]] fi occur.<ref name="nih">{{cite web|title=What Are Blood Clotting Disorders? |url=https://www.nhlbi.nih.gov/health/clotting-disorders |publisher=National Heart Lung and Blood Institute, US National Institutes of Health |access-date=9 September 2026|date=2026}}</ref> Dis fi include [[hematuria|blood insyd de urine]], [[GI bleed|blood insyd de stool]], anaa bleeding into de skin.<ref name=nih/> Complications fi include [[organ failure]].<ref name="Mer20162">{{cite web |date=September 2016 |title=Disseminated Intravascular Coagulation (DIC) - Hematology and Oncology |url=https://www.merckmanuals.com/en-ca/professional/hematology-and-oncology/coagulation-disorders/disseminated-intravascular-coagulation-dic |access-date=20 December 2017 |website=Merck Manuals Professional Edition |language=en-CA}}</ref> Relatively common causes dey include [[sepsis]], [[surgery]], [[major trauma]], [[cancer]], den [[complications of pregnancy]].<ref name=nih/> Less common causes dey include [[snake bites]], [[frostbite]], den [[burn]]s.<ref name=nih/> Der be two main types: acute (rapid onset) den chronic (slow onset).<ref name=nih/> Diagnosis typically be based on [[blood tests]].<ref name=Mer2016/> Findings fi include [[thrombocytopenia|low platelets]], low [[fibrinogen]], high [[International normalized ratio|INR]], anaa high [[D-dimer]].<ref name=Mer2016>{{cite web|title=Disseminated Intravascular Coagulation (DIC) - Hematology and Oncology|url=https://www.merckmanuals.com/en-ca/professional/hematology-and-oncology/coagulation-disorders/disseminated-intravascular-coagulation-dic|website=Merck Manuals Professional Edition|access-date=20 December 2017|language=en-CA|date=September 2016}}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] 12u8cq9vdn4mg830yg1v4snv108bls6