Wikipedia gpewiki https://gpe.wikipedia.org/wiki/Main_Page MediaWiki 1.47.0-wmf.24 first-letter Media Special Talk User User talk Wikipedia Wikipedia talk File File talk MediaWiki MediaWiki talk Template Template talk Help Help talk Category Category talk TimedText TimedText talk Module Module talk Event Event talk 0 18827 115087 115067 2026-10-20T17:38:50Z DaSupremo 9 Reverted edit by [[Special:Contributions/~2026-56271-03|~2026-56271-03]] ([[User talk:~2026-56271-03|talk]]) to last revision by [[User:DaSupremo|DaSupremo]] 76069 wikitext text/x-wiki {{Databox}} '''Martin Appiah-Danquah''' be a Ghanaian politician den farmer.<ref name=":0">{{Cite book|url=https://books.google.com/books?id=z-4bAQAAMAAJ&q=Martin+Appiah-Danquah|title=Ghanaian|date=1960|publisher=Star Publishing Company, Limited|language=en}}</ref> == Personal life den education == Appiah-Danquah born on 21 September 1924.<ref name=":1">{{Cite book|last=Aryeh|first=Elvis D.|url=https://books.google.com/books?id=sF-QDJPbIUQC&dq=Martin+Appiah-Danquah&pg=PA20|title=Daily Graphic: Issue 1,4460 June 6 1997|date=1997-06-06|publisher=Graphic Communications Group|language=en}}</ref> He come from Nkawie insyd de Atwima Mponua District for Ashanti Region of Ghana. He take ein basic education for English Church Mission School for Nkawie. For 1940, he continue ein education for Akim Abuakwa State College for Kibi, wey dey Eastern Region of Ghana. Appiah-Danquah be Ashanti.<ref name=":2">{{Cite book|last=Biswal|first=Tapan Prasad|url=https://books.google.com/books?id=r9DMGsknZNsC&dq=Martin+Appiah-Danquah&pg=PA71|title=Ghana, Political and Constitutional Developments|date=1992|publisher=Northern Book Centre|isbn=978-81-7211-029-1|language=en}}</ref> He marry Sophia Appiah-Danquah.<ref name=":1" /><ref>{{Cite web|last=Addai-Sebo|first=Akyaaba|date=26 September 2019|title=CPP Loses A Mother|url=https://www.modernghana.com/news/957280/cpp-loses-a-mother.html|access-date=1 December 2023|website=Modern Ghana}}</ref> Martin Appiah-Danquah die on 6 June 1996.<ref name=":1" /> == Career == For January 1954, Appiah-Danquah take appointment as de Secretary-General of de United Ghana Farmers' Council Co-operatives wey he hold till 1966.<ref>{{Cite book|last=Ghana|url=https://books.google.com/books?id=zBsxAQAAIAAJ&dq=Martin+Appiah-Danquah&pg=PA17|title=White Paper on the Report of the Jiagge Commission of Enquiry Into the Assets of Specified Persons|date=1969|publisher=Ghana Publishing Corporation|language=en}}</ref><ref>{{Cite book|last=Agency|first=United States Central Intelligence|url=https://books.google.com/books?id=P5GVeIuAuywC&dq=Martin+Appiah-Danquah&pg=RA8-PA8|title=Daily Report, Foreign Radio Broadcasts|date=1962|language=en}}</ref><ref>{{Cite book|last=Relations|first=Great Britain Office of Commonwealth|url=https://books.google.com/books?id=8gwkah7zdGsC&dq=Martin+Appiah-Danquah&pg=PA262|title=The Commonwealth Relations Office Year Book|date=1962|publisher=H.M. Stationery Office|language=en}}</ref> For 1961, he too serve as Ambassador Extraordinary plus Minister Plenipotentiary.<ref>{{Cite book|last=Vieta|first=Kojo T.|url=https://books.google.com/books?id=uw0OAQAAMAAJ&q=Martin+Appiah-Danquah|title=The Flagbearers of Ghana: Profiles of One Hundred Distinguished Ghanians|date=1999|publisher=Ena Publications|isbn=978-9988-0-0138-4|language=en}}</ref><ref>{{Cite book|last=Apter|first=David E.|url=https://books.google.com/books?id=lEp9BgAAQBAJ&dq=Martin+Appiah-Danquah&pg=PA344|title=Ghana in Transition|date=2015-03-08|publisher=Princeton University Press|isbn=978-1-4008-6702-8|language=en}}</ref> He be Chairman of de National Cooperative Council too.<ref>{{Cite book|url=https://books.google.com/books?id=h_MmkjrM9XQC&dq=Martin+Appiah-Danquah&pg=PA295|title=Political Parties and National Integration in Tropical Africa|publisher=University of California Press|language=en}}</ref><ref>{{Cite book|last1=Coleman|first1=James S.|url=https://books.google.com/books?id=iRa6EAAAQBAJ&dq=Martin+Appiah-Danquah&pg=PA298|title=Political Parties and National Integration in Tropical Africa|last2=Rosberg|first2=Carl G.|date=2023-04-28|publisher=Univ of California Press|isbn=978-0-520-31175-6|language=en}}</ref> == Politics == Appiah-Danquah den a member of de Convention Peoples Party (CPP).<ref>{{Cite book|last=Judiciary|first=United States Congress Senate Committee on the|url=https://books.google.com/books?id=pxo3AQAAIAAJ&dq=Martin+Appiah-Danquah&pg=PA160|title=Is U.S. Money Aiding Another Communist State?: Hearing Before the Subcommittee to Investigate the Administration of the Internal Security Act and Other Internal Security Laws of the Committee on the Judiciary, United States Senate, Eighty-seventh Congress, Second Session|date=1963|publisher=U.S. Government Printing Office|language=en}}</ref> == Controversy == Insyd May 1969, Appiah-Danquah be one of de 21 former CPP members wey dem accuse say dem unlawfully gather wealth wey reach 96,647.20 cedi, so de Government of Ghana seize ein houses.<ref>{{Cite book|last=Ofori|first=Henry|url=https://books.google.com/books?id=1zENBPwcRoEC&dq=Martin+Appiah-Danquah&pg=PA1|title=Daily Graphic: Issue 5,788 May 12 1969|date=1969-05-12|publisher=Graphic Communications Group|language=en}}</ref> == References == [[Category:1924 births]] [[Category:1996 deaths]] [[Category:Ghanaians]] [[Category:Human]] [[Category:Ghanaian farmers]] [[Category:Politicians wey komot Ashanti Region]] [[Category:Abuakwa State College alumni]] [[Category:Convention People's Party (Ghana) politicians]] [[Category:Ashanti people]] [[Category:Ghanaian MPs 1965–1966]] 3anzt2ayfdeixqfbqyu9e9pruyocxo9 0 31099 115070 115069 2026-10-20T12:04:11Z DaSupremo 9 Improve article 115070 wikitext text/x-wiki {{Databox}} '''Seborrhoeic dermatitis''' anaa '''seborrheic dermatitis''' (wey dey depend upon de [[English orthography|variety of English]] dem use) be a long-term [[skin disorder]].<ref name="Ijaz20172">{{cite journal |vauthors=Ijaz N, Fitzgerald D |date=June 2017 |title=Seborrhoeic dermatitis |journal=British Journal of Hospital Medicine |volume=78 |issue=6 |pages=C88–C91 |doi=10.12968/hmed.2017.78.6.C88 |pmid=28614013}}</ref><ref name="mayo">{{cite web|url=https://www.mayoclinic.org/diseases-conditions/seborrheic-dermatitis/symptoms-causes/syc-20352710|publisher=Mayo Clinic|date=19 July 2024|access-date=29 August 2026|title=Seborrheic dermatitis}}</ref> Symptoms dey include flaky, scaly, greasy, den occasionally itchy den inflamed skin.<ref name="Mer20192">{{cite web |title=Seborrheic Dermatitis - Dermatologic Disorders |url=https://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20200126133903/https://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/seborrheic-dermatitis |archive-date=26 January 2020 |access-date=22 November 2019 |website=Merck Manuals Professional Edition}}</ref><ref name="Borda20192">{{cite journal |vauthors=Borda LJ, Perper M, Keri JE |date=March 2019 |title=Treatment of seborrheic dermatitis: a comprehensive review |journal=The Journal of Dermatological Treatment |volume=30 |issue=2 |pages=158–169 |doi=10.1080/09546634.2018.1473554 |pmid=29737895 |s2cid=13686180}}</ref> Areas of de skin rich insyd [[sebum|oil]]-producing [[gland]]s often be affected wey dey include de [[scalp]], face, den chest.<ref name="Ijaz20172" /> E fi result in social anaa self-esteem problems.<ref name="Ijaz20172" /> Insyd babies, wen de scalp primarily be involved, e be called [[cradle cap]].<ref name="Mer20192" /> Mild seborrhoeic dermatitis of de scalp fi be described insyd lay terms as [[dandruff]] secof de dry, flaky character of de skin.<ref name="Naldi20152">{{cite journal |vauthors=Naldi L, Diphoorn J |date=May 2015 |title=Seborrhoeic dermatitis of the scalp |journal=BMJ Clinical Evidence |volume=2015 |pmc=4445675 |pmid=26016669}}</ref> As dandruff fi refer to any dryness anaa scaling of de scalp, no be all dandruff be seborrhoeic dermatitis.<ref name="Naldi20152" /> Seborrhoeic dermatitis sam times be inaccurately referred to as [[seborrhoea]].<ref name="Ijaz20172" /> De cause be unclear buh dem believe e involve a number of genetic den environmental factors.<ref name="Ijaz20172" /><ref name=mayo/><ref name="Mer20192" /> Risk factors for seborrhoeic dermatitis dey include [[immunocompromised|poor immune function]], [[Parkinson's disease]], den [[alcoholic pancreatitis]].<ref name="Ijaz20172" /><ref name="Naldi20152" /> De condition fi worsen plus [[psychological stress|stress]] anaa during de winter.<ref name="Ijaz20172" /> ''[[Malassezia]]'' yeast be believed to play a role.<ref name="Naldi20152" /> E no be a result of poor [[hygiene]].<ref>{{cite web |title=Seborrheic dermatitis |url=https://www.aad.org/public/diseases/scaly-skin/seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20171021060831/https://www.aad.org/public/diseases/scaly-skin/seborrheic-dermatitis |archive-date=21 October 2017 |access-date=20 October 2017 |website=American Academy of Dermatology}}</ref> Diagnosis typically be clinical den based on de symptoms present.<ref name="Ijaz20172" /><ref name="Papadakis2023" /> De condition no be [[Contagious disease|contagious]].<ref>{{Cite web |title=Seborrheic Dermatitis: What is It, Diagnosis & Treatment |url=https://my.clevelandclinic.org/health/diseases/14403-seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20211017232734/https://my.clevelandclinic.org/health/diseases/14403-seborrheic-dermatitis |archive-date=2021-10-17 |access-date=2021-10-12 |publisher=Cleveland Clinic |location=Cleveland, Ohio}}</ref> == References == <references /> [[Category:Translated from MDWiki]] == External links == sfhf1mysh3rjpsdzbkyweo2upt3oj6k 115071 115070 2026-10-20T13:13:06Z DaSupremo 9 Improve article 115071 wikitext text/x-wiki {{Databox}} '''Seborrhoeic dermatitis''' anaa '''seborrheic dermatitis''' (wey dey depend upon de [[English orthography|variety of English]] dem use) be a long-term [[skin disorder]].<ref name="Ijaz20172">{{cite journal |vauthors=Ijaz N, Fitzgerald D |date=June 2017 |title=Seborrhoeic dermatitis |journal=British Journal of Hospital Medicine |volume=78 |issue=6 |pages=C88–C91 |doi=10.12968/hmed.2017.78.6.C88 |pmid=28614013}}</ref><ref name="mayo">{{cite web|url=https://www.mayoclinic.org/diseases-conditions/seborrheic-dermatitis/symptoms-causes/syc-20352710|publisher=Mayo Clinic|date=19 July 2024|access-date=29 August 2026|title=Seborrheic dermatitis}}</ref> Symptoms dey include flaky, scaly, greasy, den occasionally itchy den inflamed skin.<ref name="Mer20192">{{cite web |title=Seborrheic Dermatitis - Dermatologic Disorders |url=https://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20200126133903/https://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/seborrheic-dermatitis |archive-date=26 January 2020 |access-date=22 November 2019 |website=Merck Manuals Professional Edition}}</ref><ref name="Borda20192">{{cite journal |vauthors=Borda LJ, Perper M, Keri JE |date=March 2019 |title=Treatment of seborrheic dermatitis: a comprehensive review |journal=The Journal of Dermatological Treatment |volume=30 |issue=2 |pages=158–169 |doi=10.1080/09546634.2018.1473554 |pmid=29737895 |s2cid=13686180}}</ref> Areas of de skin rich insyd [[sebum|oil]]-producing [[gland]]s often be affected wey dey include de [[scalp]], face, den chest.<ref name="Ijaz20172" /> E fi result in social anaa self-esteem problems.<ref name="Ijaz20172" /> Insyd babies, wen de scalp primarily be involved, e be called [[cradle cap]].<ref name="Mer20192" /> Mild seborrhoeic dermatitis of de scalp fi be described insyd lay terms as [[dandruff]] secof de dry, flaky character of de skin.<ref name="Naldi20152">{{cite journal |vauthors=Naldi L, Diphoorn J |date=May 2015 |title=Seborrhoeic dermatitis of the scalp |journal=BMJ Clinical Evidence |volume=2015 |pmc=4445675 |pmid=26016669}}</ref> As dandruff fi refer to any dryness anaa scaling of de scalp, no be all dandruff be seborrhoeic dermatitis.<ref name="Naldi20152" /> Seborrhoeic dermatitis sam times be inaccurately referred to as [[seborrhoea]].<ref name="Ijaz20172" /> De cause be unclear buh dem believe e involve a number of genetic den environmental factors.<ref name="Ijaz20172" /><ref name=mayo/><ref name="Mer20192" /> Risk factors for seborrhoeic dermatitis dey include [[immunocompromised|poor immune function]], [[Parkinson's disease]], den [[alcoholic pancreatitis]].<ref name="Ijaz20172" /><ref name="Naldi20152" /> De condition fi worsen plus [[psychological stress|stress]] anaa during de winter.<ref name="Ijaz20172" /> ''[[Malassezia]]'' yeast be believed to play a role.<ref name="Naldi20152" /> E no be a result of poor [[hygiene]].<ref>{{cite web |title=Seborrheic dermatitis |url=https://www.aad.org/public/diseases/scaly-skin/seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20171021060831/https://www.aad.org/public/diseases/scaly-skin/seborrheic-dermatitis |archive-date=21 October 2017 |access-date=20 October 2017 |website=American Academy of Dermatology}}</ref> Diagnosis typically be clinical den based on de symptoms present.<ref name="Ijaz20172" /><ref name="Papadakis20232">{{Cite book |title=Quick Medical Diagnosis & Treatment 2023 |vauthors=Papadakis MA, McPhee SJ |publisher=McGraw-Hill Education |year=2023 |isbn=978-1-264-68734-3 |edition=2023 |chapter=Dermatitis, Seborrheic}}</ref> De condition no be [[Contagious disease|contagious]].<ref>{{Cite web |title=Seborrheic Dermatitis: What is It, Diagnosis & Treatment |url=https://my.clevelandclinic.org/health/diseases/14403-seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20211017232734/https://my.clevelandclinic.org/health/diseases/14403-seborrheic-dermatitis |archive-date=2021-10-17 |access-date=2021-10-12 |publisher=Cleveland Clinic |location=Cleveland, Ohio}}</ref> De condition be common insyd infants within de first three months of age den adults aged 30 to 70 years.<ref name="Mer2019" /><ref name="Ijaz2017">{{cite journal |vauthors=Ijaz N, Fitzgerald D |date=June 2017 |title=Seborrhoeic dermatitis |journal=British Journal of Hospital Medicine |volume=78 |issue=6 |pages=C88–C91 |doi=10.12968/hmed.2017.78.6.C88 |pmid=28614013}}</ref><ref name="Nobles2021">{{cite book |title=StatPearls [Internet] |vauthors=Nobles T, Harberger S, Krishnamurthy K |date=August 2021 |publisher=StatPearls Publishing |location=Treasure Island (FL) |chapter=Cradle Cap |pmid=30285358 |access-date=2022-02-26 |chapter-url=https://www.ncbi.nlm.nih.gov/books/NBK531463/ |archive-url=https://web.archive.org/web/20210121064801/https://www.ncbi.nlm.nih.gov/books/NBK531463/ |archive-date=2021-01-21 |url-status=live}}</ref> E be more common insyd males,<ref name="Jackson2022">{{cite journal |vauthors=Jackson JM, Alexis A, Zirwas M, Taylor S |date=December 2022 |title=Unmet needs for patients with seborrheic dermatitis |journal=Journal of the American Academy of Dermatology |volume=90 |issue=3 |pages=S0190–9622(22)03307–2 |doi=10.1016/j.jaad.2022.12.017 |pmid=36538948 |s2cid=254843412 |doi-access=free}}</ref> African Americans, de [[immunodeficiency|immunocompromised]] (such as those plus HIV), den those plus Parkinson's disease.<ref name="Dinulos2021" /><ref name="Jackson2022" /> == References == <references /> [[Category:Translated from MDWiki]] == External links == 4konk766xtzdfv2tindz13fhzf0skqa 115072 115071 2026-10-20T13:22:31Z DaSupremo 9 Improve article 115072 wikitext text/x-wiki {{Databox}} '''Seborrhoeic dermatitis''' anaa '''seborrheic dermatitis''' (wey dey depend upon de [[English orthography|variety of English]] dem use) be a long-term [[skin disorder]].<ref name="Ijaz20172">{{cite journal |vauthors=Ijaz N, Fitzgerald D |date=June 2017 |title=Seborrhoeic dermatitis |journal=British Journal of Hospital Medicine |volume=78 |issue=6 |pages=C88–C91 |doi=10.12968/hmed.2017.78.6.C88 |pmid=28614013}}</ref><ref name="mayo">{{cite web|url=https://www.mayoclinic.org/diseases-conditions/seborrheic-dermatitis/symptoms-causes/syc-20352710|publisher=Mayo Clinic|date=19 July 2024|access-date=29 August 2026|title=Seborrheic dermatitis}}</ref> Symptoms dey include flaky, scaly, greasy, den occasionally itchy den inflamed skin.<ref name="Mer20192">{{cite web |title=Seborrheic Dermatitis - Dermatologic Disorders |url=https://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20200126133903/https://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/seborrheic-dermatitis |archive-date=26 January 2020 |access-date=22 November 2019 |website=Merck Manuals Professional Edition}}</ref><ref name="Borda20192">{{cite journal |vauthors=Borda LJ, Perper M, Keri JE |date=March 2019 |title=Treatment of seborrheic dermatitis: a comprehensive review |journal=The Journal of Dermatological Treatment |volume=30 |issue=2 |pages=158–169 |doi=10.1080/09546634.2018.1473554 |pmid=29737895 |s2cid=13686180}}</ref> Areas of de skin rich insyd [[sebum|oil]]-producing [[gland]]s often be affected wey dey include de [[scalp]], face, den chest.<ref name="Ijaz20172" /> E fi result in social anaa self-esteem problems.<ref name="Ijaz20172" /> Insyd babies, wen de scalp primarily be involved, e be called [[cradle cap]].<ref name="Mer20192" /> Mild seborrhoeic dermatitis of de scalp fi be described insyd lay terms as [[dandruff]] secof de dry, flaky character of de skin.<ref name="Naldi20152">{{cite journal |vauthors=Naldi L, Diphoorn J |date=May 2015 |title=Seborrhoeic dermatitis of the scalp |journal=BMJ Clinical Evidence |volume=2015 |pmc=4445675 |pmid=26016669}}</ref> As dandruff fi refer to any dryness anaa scaling of de scalp, no be all dandruff be seborrhoeic dermatitis.<ref name="Naldi20152" /> Seborrhoeic dermatitis sam times be inaccurately referred to as [[seborrhoea]].<ref name="Ijaz20172" /> De cause be unclear buh dem believe e involve a number of genetic den environmental factors.<ref name="Ijaz20172" /><ref name=mayo/><ref name="Mer20192" /> Risk factors for seborrhoeic dermatitis dey include [[immunocompromised|poor immune function]], [[Parkinson's disease]], den [[alcoholic pancreatitis]].<ref name="Ijaz20172" /><ref name="Naldi20152" /> De condition fi worsen plus [[psychological stress|stress]] anaa during de winter.<ref name="Ijaz20172" /> ''[[Malassezia]]'' yeast be believed to play a role.<ref name="Naldi20152" /> E no be a result of poor [[hygiene]].<ref>{{cite web |title=Seborrheic dermatitis |url=https://www.aad.org/public/diseases/scaly-skin/seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20171021060831/https://www.aad.org/public/diseases/scaly-skin/seborrheic-dermatitis |archive-date=21 October 2017 |access-date=20 October 2017 |website=American Academy of Dermatology}}</ref> Diagnosis typically be clinical den based on de symptoms present.<ref name="Ijaz20172" /><ref name="Papadakis20232">{{Cite book |title=Quick Medical Diagnosis & Treatment 2023 |vauthors=Papadakis MA, McPhee SJ |publisher=McGraw-Hill Education |year=2023 |isbn=978-1-264-68734-3 |edition=2023 |chapter=Dermatitis, Seborrheic}}</ref> De condition no be [[Contagious disease|contagious]].<ref>{{Cite web |title=Seborrheic Dermatitis: What is It, Diagnosis & Treatment |url=https://my.clevelandclinic.org/health/diseases/14403-seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20211017232734/https://my.clevelandclinic.org/health/diseases/14403-seborrheic-dermatitis |archive-date=2021-10-17 |access-date=2021-10-12 |publisher=Cleveland Clinic |location=Cleveland, Ohio}}</ref> De typical treatment be topical [[antifungal medications|antifungal cream]] den [[anti-inflammatory agents]].<ref name="Borda20192" /> Specifically, [[ketoconazole]] anaa [[ciclopirox]] be effective.<ref name="Okokon2015">{{cite journal |vauthors=Okokon EO, Verbeek JH, Ruotsalainen JH, Ojo OA, Bakhoya VN |date=May 2015 |title=Topical antifungals for seborrhoeic dermatitis |journal=The Cochrane Database of Systematic Reviews |volume=4 |issue=5 |article-number=CD008138 |doi=10.1002/14651858.CD008138.pub3 |pmc=4448221 |pmid=25933684 |veditors=Okokon EO}}</ref> Seborrhoeic dermatitis of de scalp often be treated plus shampoo preparations of ketoconazole, [[zinc pyrithione]], [[piroctone olamine]] den [[selenium disulfide]].<ref name="Dinulos20212">{{Cite book |title=Habif's Clinical Dermatology, Seventh Edition |vauthors=Dinulos JG |publisher=Elsevier Inc |year=2021 |isbn=978-0-323-61269-2 |edition=7th}}</ref><ref name="Tang2023">{{Cite journal |last1=Tang |first1=Chun Fung |last2=Paz-Alvarez |first2=Miguel |last3=Pudney |first3=Paul D. A. |last4=Lane |first4=Majella E. |date=June 2023 |title=Characterization of piroctone olamine for topical delivery to the skin |journal=International Journal of Cosmetic Science |volume=45 |issue=3 |pages=345–353 |doi=10.1111/ics.12839 |issn=1468-2494 |pmc=10947268 |pmid=36752028}}</ref> Gentle, non-irritating cleansers den moisturizers often be used alongside medicated treatments to maintain de skin barrier. De condition be common insyd infants within de first three months of age den adults aged 30 to 70 years.<ref name="Ijaz20172" /><ref name="Mer20192" /><ref name="Nobles2021">{{cite book |title=StatPearls [Internet] |vauthors=Nobles T, Harberger S, Krishnamurthy K |date=August 2021 |publisher=StatPearls Publishing |location=Treasure Island (FL) |chapter=Cradle Cap |pmid=30285358 |access-date=2022-02-26 |chapter-url=https://www.ncbi.nlm.nih.gov/books/NBK531463/ |archive-url=https://web.archive.org/web/20210121064801/https://www.ncbi.nlm.nih.gov/books/NBK531463/ |archive-date=2021-01-21 |url-status=live}}</ref> E be more common insyd males,<ref name="Jackson2022">{{cite journal |vauthors=Jackson JM, Alexis A, Zirwas M, Taylor S |date=December 2022 |title=Unmet needs for patients with seborrheic dermatitis |journal=Journal of the American Academy of Dermatology |volume=90 |issue=3 |pages=S0190–9622(22)03307–2 |doi=10.1016/j.jaad.2022.12.017 |pmid=36538948 |s2cid=254843412 |doi-access=free}}</ref> African Americans, de [[immunodeficiency|immunocompromised]] (such as those plus HIV), den those plus Parkinson's disease.<ref name="Dinulos20212" /><ref name="Jackson2022" /> == References == <references /> == External links == [[Category:Translated from MDWiki]] n38eq0e0ps4dulix601dtb67ioexn5i 115073 115072 2026-10-20T13:27:20Z DaSupremo 9 Improve article 115073 wikitext text/x-wiki {{Databox}} '''Seborrhoeic dermatitis''' anaa '''seborrheic dermatitis''' (wey dey depend upon de [[English orthography|variety of English]] dem use) be a long-term [[skin disorder]].<ref name="Ijaz20172">{{cite journal |vauthors=Ijaz N, Fitzgerald D |date=June 2017 |title=Seborrhoeic dermatitis |journal=British Journal of Hospital Medicine |volume=78 |issue=6 |pages=C88–C91 |doi=10.12968/hmed.2017.78.6.C88 |pmid=28614013}}</ref><ref name="mayo">{{cite web|url=https://www.mayoclinic.org/diseases-conditions/seborrheic-dermatitis/symptoms-causes/syc-20352710|publisher=Mayo Clinic|date=19 July 2024|access-date=29 August 2026|title=Seborrheic dermatitis}}</ref> Symptoms dey include flaky, scaly, greasy, den occasionally itchy den inflamed skin.<ref name="Mer20192">{{cite web |title=Seborrheic Dermatitis - Dermatologic Disorders |url=https://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20200126133903/https://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/seborrheic-dermatitis |archive-date=26 January 2020 |access-date=22 November 2019 |website=Merck Manuals Professional Edition}}</ref><ref name="Borda20192">{{cite journal |vauthors=Borda LJ, Perper M, Keri JE |date=March 2019 |title=Treatment of seborrheic dermatitis: a comprehensive review |journal=The Journal of Dermatological Treatment |volume=30 |issue=2 |pages=158–169 |doi=10.1080/09546634.2018.1473554 |pmid=29737895 |s2cid=13686180}}</ref> Areas of de skin rich insyd [[sebum|oil]]-producing [[gland]]s often be affected wey dey include de [[scalp]], face, den chest.<ref name="Ijaz20172" /> E fi result in social anaa self-esteem problems.<ref name="Ijaz20172" /> Insyd babies, wen de scalp primarily be involved, e be called [[cradle cap]].<ref name="Mer20192" /> Mild seborrhoeic dermatitis of de scalp fi be described insyd lay terms as [[dandruff]] secof de dry, flaky character of de skin.<ref name="Naldi20152">{{cite journal |vauthors=Naldi L, Diphoorn J |date=May 2015 |title=Seborrhoeic dermatitis of the scalp |journal=BMJ Clinical Evidence |volume=2015 |pmc=4445675 |pmid=26016669}}</ref> As dandruff fi refer to any dryness anaa scaling of de scalp, no be all dandruff be seborrhoeic dermatitis.<ref name="Naldi20152" /> Seborrhoeic dermatitis sam times be inaccurately referred to as [[seborrhoea]].<ref name="Ijaz20172" /> De cause be unclear buh dem believe e involve a number of genetic den environmental factors.<ref name="Ijaz20172" /><ref name=mayo/><ref name="Mer20192" /> Risk factors for seborrhoeic dermatitis dey include [[immunocompromised|poor immune function]], [[Parkinson's disease]], den [[alcoholic pancreatitis]].<ref name="Ijaz20172" /><ref name="Naldi20152" /> De condition fi worsen plus [[psychological stress|stress]] anaa during de winter.<ref name="Ijaz20172" /> ''[[Malassezia]]'' yeast be believed to play a role.<ref name="Naldi20152" /> E no be a result of poor [[hygiene]].<ref>{{cite web |title=Seborrheic dermatitis |url=https://www.aad.org/public/diseases/scaly-skin/seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20171021060831/https://www.aad.org/public/diseases/scaly-skin/seborrheic-dermatitis |archive-date=21 October 2017 |access-date=20 October 2017 |website=American Academy of Dermatology}}</ref> Diagnosis typically be clinical den based on de symptoms present.<ref name="Ijaz20172" /><ref name="Papadakis20232">{{Cite book |title=Quick Medical Diagnosis & Treatment 2023 |vauthors=Papadakis MA, McPhee SJ |publisher=McGraw-Hill Education |year=2023 |isbn=978-1-264-68734-3 |edition=2023 |chapter=Dermatitis, Seborrheic}}</ref> De condition no be [[Contagious disease|contagious]].<ref>{{Cite web |title=Seborrheic Dermatitis: What is It, Diagnosis & Treatment |url=https://my.clevelandclinic.org/health/diseases/14403-seborrheic-dermatitis |url-status=live |archive-url=https://web.archive.org/web/20211017232734/https://my.clevelandclinic.org/health/diseases/14403-seborrheic-dermatitis |archive-date=2021-10-17 |access-date=2021-10-12 |publisher=Cleveland Clinic |location=Cleveland, Ohio}}</ref> De typical treatment be topical [[antifungal medications|antifungal cream]] den [[anti-inflammatory agents]].<ref name="Borda20192" /> Specifically, [[ketoconazole]] anaa [[ciclopirox]] be effective.<ref name="Okokon2015">{{cite journal |vauthors=Okokon EO, Verbeek JH, Ruotsalainen JH, Ojo OA, Bakhoya VN |date=May 2015 |title=Topical antifungals for seborrhoeic dermatitis |journal=The Cochrane Database of Systematic Reviews |volume=4 |issue=5 |article-number=CD008138 |doi=10.1002/14651858.CD008138.pub3 |pmc=4448221 |pmid=25933684 |veditors=Okokon EO}}</ref> Seborrhoeic dermatitis of de scalp often be treated plus shampoo preparations of ketoconazole, [[zinc pyrithione]], [[piroctone olamine]] den [[selenium disulfide]].<ref name="Dinulos20212">{{Cite book |title=Habif's Clinical Dermatology, Seventh Edition |vauthors=Dinulos JG |publisher=Elsevier Inc |year=2021 |isbn=978-0-323-61269-2 |edition=7th}}</ref><ref name="Tang2023">{{Cite journal |last1=Tang |first1=Chun Fung |last2=Paz-Alvarez |first2=Miguel |last3=Pudney |first3=Paul D. A. |last4=Lane |first4=Majella E. |date=June 2023 |title=Characterization of piroctone olamine for topical delivery to the skin |journal=International Journal of Cosmetic Science |volume=45 |issue=3 |pages=345–353 |doi=10.1111/ics.12839 |issn=1468-2494 |pmc=10947268 |pmid=36752028}}</ref> Gentle, non-irritating cleansers den moisturizers often be used alongside medicated treatments to maintain de skin barrier. De condition be common insyd infants within de first three months of age den adults aged 30 to 70 years.<ref name="Ijaz20172" /><ref name="Mer20192" /><ref name="Nobles2021">{{cite book |title=StatPearls [Internet] |vauthors=Nobles T, Harberger S, Krishnamurthy K |date=August 2021 |publisher=StatPearls Publishing |location=Treasure Island (FL) |chapter=Cradle Cap |pmid=30285358 |access-date=2022-02-26 |chapter-url=https://www.ncbi.nlm.nih.gov/books/NBK531463/ |archive-url=https://web.archive.org/web/20210121064801/https://www.ncbi.nlm.nih.gov/books/NBK531463/ |archive-date=2021-01-21 |url-status=live}}</ref> E be more common insyd males,<ref name="Jackson2022">{{cite journal |vauthors=Jackson JM, Alexis A, Zirwas M, Taylor S |date=December 2022 |title=Unmet needs for patients with seborrheic dermatitis |journal=Journal of the American Academy of Dermatology |volume=90 |issue=3 |pages=S0190–9622(22)03307–2 |doi=10.1016/j.jaad.2022.12.017 |pmid=36538948 |s2cid=254843412 |doi-access=free}}</ref> African Americans, de [[immunodeficiency|immunocompromised]] (such as those plus HIV), den those plus Parkinson's disease.<ref name="Dinulos20212" /><ref name="Jackson2022" /> == References == <references /> == External links == {{Commons category}} {{Authority control}} [[Category:Seborrheic dermatitis| ]] [[Category:Translated from MDWiki]] elifvaw7ov89bfghn16y6gb2k0v7ovh 0 31100 115074 2026-10-20T14:11:58Z DaSupremo 9 Created by translating the page [[:mdwiki:Special:Redirect/revision/1457318|Rett_syndrome]] to:gpe #mdwikicx 115074 wikitext text/x-wiki [[Category:Translated from MDWiki]] r0gf7axtnvt68k0p85plnlehx64o08u 115075 115074 2026-10-20T14:21:20Z DaSupremo 9 Improve article 115075 wikitext text/x-wiki {{Databox}} '''Rett syndrome''' ('''RTT''') be a [[genetic disorder]] wey typically cam be apparent after 6–18 months of age den almost exclusively insyd girlies.<ref name=GHR2013>{{cite web|title=Rett syndrome|url=https://medlineplus.gov/genetics/condition/rett-syndrome/|website=Genetics Home Reference|access-date=14 October 2017|language=en|date=December 2013|url-status=live|archive-url=https://web.archive.org/web/20171014183826/https://ghr.nlm.nih.gov/condition/rett-syndrome|archive-date=14 October 2017}}</ref> Symptoms dey include impairments insyd language den coordination, den repetitive movements.<ref name=GHR2013/> Those affected often get slower growth, difficulty walking, den a [[microcephaly|smaller head size]].<ref name=GHR2013/><ref name=NIH2017>{{cite web|title=Rett Syndrome Fact Sheet|url=https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Rett-Syndrome-Fact-Sheet|website=National Institute of Neurological Disorders and Stroke|access-date=14 October 2017|archive-url=https://web.archive.org/web/20171014183306/https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Rett-Syndrome-Fact-Sheet|archive-date=14 October 2017}}</ref> Complications of Rett syndrome fi include [[seizures]], [[scoliosis]], den [[sleeping problems]].<ref name=GHR2013/> De severity of de condition be variable.<ref name=NIH2017/> == References == <references /> == External links == [[Category:Translated from MDWiki]] 8zzcewwp8krlp4zcds79tvp3bqjqqao 115076 115075 2026-10-20T14:23:43Z DaSupremo 9 Improve article 115076 wikitext text/x-wiki {{Databox}} '''Rett syndrome''' ('''RTT''') be a [[genetic disorder]] wey typically cam be apparent after 6–18 months of age den almost exclusively insyd girlies.<ref name=GHR2013>{{cite web|title=Rett syndrome|url=https://medlineplus.gov/genetics/condition/rett-syndrome/|website=Genetics Home Reference|access-date=14 October 2017|language=en|date=December 2013|url-status=live|archive-url=https://web.archive.org/web/20171014183826/https://ghr.nlm.nih.gov/condition/rett-syndrome|archive-date=14 October 2017}}</ref> Symptoms dey include impairments insyd language den coordination, den repetitive movements.<ref name=GHR2013/> Those affected often get slower growth, difficulty walking, den a [[microcephaly|smaller head size]].<ref name=GHR2013/><ref name=NIH2017>{{cite web|title=Rett Syndrome Fact Sheet|url=https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Rett-Syndrome-Fact-Sheet|website=National Institute of Neurological Disorders and Stroke|access-date=14 October 2017|archive-url=https://web.archive.org/web/20171014183306/https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Rett-Syndrome-Fact-Sheet|archive-date=14 October 2017}}</ref> Complications of Rett syndrome fi include [[seizures]], [[scoliosis]], den [[sleeping problems]].<ref name=GHR2013/> De severity of de condition be variable.<ref name=NIH2017/> Rett syndrome be secof a genetic mutation, usually insyd de ''[[MECP2]]'' gene,<ref name=GHR2013/> on de [[X chromosome]].<ref name=NIH2017/><ref name=":4">{{Cite journal |last1=Neul |first1=Jeffrey L. |last2=Kaufmann |first2=Walter E. |last3=Glaze |first3=Daniel G. |last4=Christodoulou |first4=John |last5=Clarke |first5=Angus J. |last6=Bahi-Buisson |first6=Nadia |last7=Leonard |first7=Helen |last8=Bailey |first8=Mark E. S. |last9=Schanen |first9=N. Carolyn |last10=Zappella |first10=Michele |last11=Renieri |first11=Alessandra |last12=Huppke |first12=Peter |last13=Percy |first13=Alan K. |date=2010 |title=Rett Syndrome: Revised Diagnostic Criteria and Nomenclature |journal=Annals of Neurology |volume=68 |issue=6 |pages=944–950 |doi=10.1002/ana.22124 |issn=0364-5134 |pmc=3058521 |pmid=21154482}}</ref> E almost always dey occur as a new mutation, plus less dan one percent of cases be inherited.<ref name=GHR2013/><ref name=NIH2017/> E dey occur almost exclusively insyd girlies;<ref name=GHR2013/> boys wey get a similar mutation typically die shortly after birth.<ref name=NIH2017/> Diagnosis be based on de symptoms<ref name=":4" /> wey e fi be confirmed plus [[genetic testing]].<ref name=NIH2017/> == References == <references /> == External links == [[Category:Translated from MDWiki]] j326yw9mccxkhj09qjkw4wxf6liv2p9 115077 115076 2026-10-20T14:25:36Z DaSupremo 9 Improve article 115077 wikitext text/x-wiki {{Databox}} '''Rett syndrome''' ('''RTT''') be a [[genetic disorder]] wey typically cam be apparent after 6–18 months of age den almost exclusively insyd girlies.<ref name=GHR2013>{{cite web|title=Rett syndrome|url=https://medlineplus.gov/genetics/condition/rett-syndrome/|website=Genetics Home Reference|access-date=14 October 2017|language=en|date=December 2013|url-status=live|archive-url=https://web.archive.org/web/20171014183826/https://ghr.nlm.nih.gov/condition/rett-syndrome|archive-date=14 October 2017}}</ref> Symptoms dey include impairments insyd language den coordination, den repetitive movements.<ref name=GHR2013/> Those affected often get slower growth, difficulty walking, den a [[microcephaly|smaller head size]].<ref name=GHR2013/><ref name=NIH2017>{{cite web|title=Rett Syndrome Fact Sheet|url=https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Rett-Syndrome-Fact-Sheet|website=National Institute of Neurological Disorders and Stroke|access-date=14 October 2017|archive-url=https://web.archive.org/web/20171014183306/https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Rett-Syndrome-Fact-Sheet|archive-date=14 October 2017}}</ref> Complications of Rett syndrome fi include [[seizures]], [[scoliosis]], den [[sleeping problems]].<ref name=GHR2013/> De severity of de condition be variable.<ref name=NIH2017/> Rett syndrome be secof a genetic mutation, usually insyd de ''[[MECP2]]'' gene,<ref name=GHR2013/> on de [[X chromosome]].<ref name=NIH2017/><ref name=":4">{{Cite journal |last1=Neul |first1=Jeffrey L. |last2=Kaufmann |first2=Walter E. |last3=Glaze |first3=Daniel G. |last4=Christodoulou |first4=John |last5=Clarke |first5=Angus J. |last6=Bahi-Buisson |first6=Nadia |last7=Leonard |first7=Helen |last8=Bailey |first8=Mark E. S. |last9=Schanen |first9=N. Carolyn |last10=Zappella |first10=Michele |last11=Renieri |first11=Alessandra |last12=Huppke |first12=Peter |last13=Percy |first13=Alan K. |date=2010 |title=Rett Syndrome: Revised Diagnostic Criteria and Nomenclature |journal=Annals of Neurology |volume=68 |issue=6 |pages=944–950 |doi=10.1002/ana.22124 |issn=0364-5134 |pmc=3058521 |pmid=21154482}}</ref> E almost always dey occur as a new mutation, plus less dan one percent of cases be inherited.<ref name=GHR2013/><ref name=NIH2017/> E dey occur almost exclusively insyd girlies;<ref name=GHR2013/> boys wey get a similar mutation typically die shortly after birth.<ref name=NIH2017/> Diagnosis be based on de symptoms<ref name=":4" /> wey e fi be confirmed plus [[genetic testing]].<ref name=NIH2017/> Der be no known cure for Rett syndrome.<ref name=NIH2017/> Treatment be directed at improving symptoms.<ref name=NIH2017/> [[Anticonvulsant]]s fi be used to help plus seizures.<ref name=NIH2017/> [[Special education]], [[Physical therapy|physiotherapy]], den leg braces sanso fi be useful wey dey depend on de needs of de kiddie.<ref name=NIH2017/> Chaw of those plus de condition live into middle age.<ref name=NIH2017/> == References == <references /> == External links == [[Category:Translated from MDWiki]] 6zbbhp0h0nbi84f5j34p35vc88i7rtr 115078 115077 2026-10-20T14:27:18Z DaSupremo 9 Improve article 115078 wikitext text/x-wiki {{Databox}} '''Rett syndrome''' ('''RTT''') be a [[genetic disorder]] wey typically cam be apparent after 6–18 months of age den almost exclusively insyd girlies.<ref name=GHR2013>{{cite web|title=Rett syndrome|url=https://medlineplus.gov/genetics/condition/rett-syndrome/|website=Genetics Home Reference|access-date=14 October 2017|language=en|date=December 2013|url-status=live|archive-url=https://web.archive.org/web/20171014183826/https://ghr.nlm.nih.gov/condition/rett-syndrome|archive-date=14 October 2017}}</ref> Symptoms dey include impairments insyd language den coordination, den repetitive movements.<ref name=GHR2013/> Those affected often get slower growth, difficulty walking, den a [[microcephaly|smaller head size]].<ref name=GHR2013/><ref name=NIH2017>{{cite web|title=Rett Syndrome Fact Sheet|url=https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Rett-Syndrome-Fact-Sheet|website=National Institute of Neurological Disorders and Stroke|access-date=14 October 2017|archive-url=https://web.archive.org/web/20171014183306/https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Rett-Syndrome-Fact-Sheet|archive-date=14 October 2017}}</ref> Complications of Rett syndrome fi include [[seizures]], [[scoliosis]], den [[sleeping problems]].<ref name=GHR2013/> De severity of de condition be variable.<ref name=NIH2017/> Rett syndrome be secof a genetic mutation, usually insyd de ''[[MECP2]]'' gene,<ref name=GHR2013/> on de [[X chromosome]].<ref name=NIH2017/><ref name=":4">{{Cite journal |last1=Neul |first1=Jeffrey L. |last2=Kaufmann |first2=Walter E. |last3=Glaze |first3=Daniel G. |last4=Christodoulou |first4=John |last5=Clarke |first5=Angus J. |last6=Bahi-Buisson |first6=Nadia |last7=Leonard |first7=Helen |last8=Bailey |first8=Mark E. S. |last9=Schanen |first9=N. Carolyn |last10=Zappella |first10=Michele |last11=Renieri |first11=Alessandra |last12=Huppke |first12=Peter |last13=Percy |first13=Alan K. |date=2010 |title=Rett Syndrome: Revised Diagnostic Criteria and Nomenclature |journal=Annals of Neurology |volume=68 |issue=6 |pages=944–950 |doi=10.1002/ana.22124 |issn=0364-5134 |pmc=3058521 |pmid=21154482}}</ref> E almost always dey occur as a new mutation, plus less dan one percent of cases be inherited.<ref name=GHR2013/><ref name=NIH2017/> E dey occur almost exclusively insyd girlies;<ref name=GHR2013/> boys wey get a similar mutation typically die shortly after birth.<ref name=NIH2017/> Diagnosis be based on de symptoms<ref name=":4" /> wey e fi be confirmed plus [[genetic testing]].<ref name=NIH2017/> Der be no known cure for Rett syndrome.<ref name=NIH2017/> Treatment be directed at improving symptoms.<ref name=NIH2017/> [[Anticonvulsant]]s fi be used to help plus seizures.<ref name=NIH2017/> [[Special education]], [[Physical therapy|physiotherapy]], den leg braces sanso fi be useful wey dey depend on de needs of de kiddie.<ref name=NIH2017/> Chaw of those plus de condition live into middle age.<ref name=NIH2017/> De condition dey affect about 1 insyd 8,500 females.<ref name=GHR2013/> Insyd 1999, Lebanese-American physician [[Huda Zoghbi]] discover de mutation wey dey cause de condition.<ref name="Per2013">{{Cite journal |last=Percy |first=Alan |date=January 2014 |title=The American History of Rett Syndrome |journal=Pediatric Neurology |volume=50 |issue=1 |pages=1–3 |doi=10.1016/j.pediatrneurol.2013.08.018|pmid=24200039 |pmc=3874243}}</ref><ref name=Huda1999>{{cite journal | doi=10.1038/13810 | title=Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 | year=1999 | last1=Amir | first1=Ruthie | last2=Van den Veyver | first2=Ignatia | last3=Wan | first3=Mimi | last4=Tran | first4=Charles | last5=Francke | first5=Uta | last6=Zoghbi | first6=Huda | s2cid=3350350 | journal=Nature Genetics | volume=23 | issue=2 | pages=185–8 | pmid=10508514}}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] 11t1d2uqmby27778rpi5i8d6731ki95 115079 115078 2026-10-20T14:51:03Z DaSupremo 9 Improve article 115079 wikitext text/x-wiki {{Databox}} '''Rett syndrome''' ('''RTT''') be a [[genetic disorder]] wey typically cam be apparent after 6–18 months of age den almost exclusively insyd girlies.<ref name=GHR2013>{{cite web|title=Rett syndrome|url=https://medlineplus.gov/genetics/condition/rett-syndrome/|website=Genetics Home Reference|access-date=14 October 2017|language=en|date=December 2013|url-status=live|archive-url=https://web.archive.org/web/20171014183826/https://ghr.nlm.nih.gov/condition/rett-syndrome|archive-date=14 October 2017}}</ref> Symptoms dey include impairments insyd language den coordination, den repetitive movements.<ref name=GHR2013/> Those affected often get slower growth, difficulty walking, den a [[microcephaly|smaller head size]].<ref name=GHR2013/><ref name=NIH2017>{{cite web|title=Rett Syndrome Fact Sheet|url=https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Rett-Syndrome-Fact-Sheet|website=National Institute of Neurological Disorders and Stroke|access-date=14 October 2017|archive-url=https://web.archive.org/web/20171014183306/https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Rett-Syndrome-Fact-Sheet|archive-date=14 October 2017}}</ref> Complications of Rett syndrome fi include [[seizures]], [[scoliosis]], den [[sleeping problems]].<ref name=GHR2013/> De severity of de condition be variable.<ref name=NIH2017/> Rett syndrome be secof a genetic mutation, usually insyd de ''[[MECP2]]'' gene,<ref name=GHR2013/> on de [[X chromosome]].<ref name=NIH2017/><ref name=":4">{{Cite journal |last1=Neul |first1=Jeffrey L. |last2=Kaufmann |first2=Walter E. |last3=Glaze |first3=Daniel G. |last4=Christodoulou |first4=John |last5=Clarke |first5=Angus J. |last6=Bahi-Buisson |first6=Nadia |last7=Leonard |first7=Helen |last8=Bailey |first8=Mark E. S. |last9=Schanen |first9=N. Carolyn |last10=Zappella |first10=Michele |last11=Renieri |first11=Alessandra |last12=Huppke |first12=Peter |last13=Percy |first13=Alan K. |date=2010 |title=Rett Syndrome: Revised Diagnostic Criteria and Nomenclature |journal=Annals of Neurology |volume=68 |issue=6 |pages=944–950 |doi=10.1002/ana.22124 |issn=0364-5134 |pmc=3058521 |pmid=21154482}}</ref> E almost always dey occur as a new mutation, plus less dan one percent of cases be inherited.<ref name=GHR2013/><ref name=NIH2017/> E dey occur almost exclusively insyd girlies;<ref name=GHR2013/> boys wey get a similar mutation typically die shortly after birth.<ref name=NIH2017/> Diagnosis be based on de symptoms<ref name=":4" /> wey e fi be confirmed plus [[genetic testing]].<ref name=NIH2017/> Der be no known cure for Rett syndrome.<ref name=NIH2017/> Treatment be directed at improving symptoms.<ref name=NIH2017/> [[Anticonvulsant]]s fi be used to help plus seizures.<ref name=NIH2017/> [[Special education]], [[Physical therapy|physiotherapy]], den leg braces sanso fi be useful wey dey depend on de needs of de kiddie.<ref name=NIH2017/> Chaw of those plus de condition live into middle age.<ref name=NIH2017/> De condition dey affect about 1 insyd 8,500 females.<ref name=GHR2013/> Insyd 1999, Lebanese-American physician [[Huda Zoghbi]] discover de mutation wey dey cause de condition.<ref name="Per2013">{{Cite journal |last=Percy |first=Alan |date=January 2014 |title=The American History of Rett Syndrome |journal=Pediatric Neurology |volume=50 |issue=1 |pages=1–3 |doi=10.1016/j.pediatrneurol.2013.08.018|pmid=24200039 |pmc=3874243}}</ref><ref name=Huda1999>{{cite journal | doi=10.1038/13810 | title=Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 | year=1999 | last1=Amir | first1=Ruthie | last2=Van den Veyver | first2=Ignatia | last3=Wan | first3=Mimi | last4=Tran | first4=Charles | last5=Francke | first5=Uta | last6=Zoghbi | first6=Huda | s2cid=3350350 | journal=Nature Genetics | volume=23 | issue=2 | pages=185–8 | pmid=10508514}}</ref> == References == <references /> == External links == {{Commons}}{{Pervasive developmental disorders}} {{Nonverbal communication}} {{Authority control}} [[Category:Communication disorders]] [[Category:Disorders wey dey cause seizures]] [[Category:Learning disabilities]] [[Category:Neurological disorders insyd kiddies]] [[Category:Pervasive developmental disorders]] [[Category:Syndromes wey dey affect de nervous system]] [[Category:Syndromic autism]] [[Category:X-linked dominant disorders]] [[Category:Genetic diseases den disorders]] [[Category:Rare syndromes]] [[Category:Translated from MDWiki]] [[Category:Diseases dem name after discoverers]] ki8yxeqiy8bv5zqh8t0fxhp6m5ij6q9 0 31101 115080 2026-10-20T15:06:57Z DaSupremo 9 Created by translating the page [[:mdwiki:Special:Redirect/revision/1456857|Treacher_Collins_syndrome]] to:gpe #mdwikicx 115080 wikitext text/x-wiki [[Category:Translated from MDWiki]] r0gf7axtnvt68k0p85plnlehx64o08u 115081 115080 2026-10-20T15:12:10Z DaSupremo 9 Improve article 115081 wikitext text/x-wiki {{Databox}} '''Treacher Collins syndrome''' ('''TCS''') be a [[genetic disorder]] wey be characterized by deformities of de ears, eyes, cheekbones, den chin.<ref name="GHR20122">{{cite web |date=June 2012 |title=Treacher Collins syndrome |url=https://medlineplus.gov/genetics/condition/treacher-collins-syndrome/ |url-status=live |archive-url=https://web.archive.org/web/20200626164632/https://ghr.nlm.nih.gov/condition/treacher-collins-syndrome |archive-date=26 June 2020 |access-date=7 November 2017 |website=Genetics Home Reference |language=en}}</ref> De degree to wich a person be affected fi vary from mild to severe.<ref name="GHR20122" /> Complications fi include breathing problems, vision problems, [[cleft palate]], den [[hearing loss]].<ref name="GHR20122" /> Those affected generally get normal intelligence.<ref name="GHR20122" /> == References == [[Category:Translated from MDWiki]] <references /> == External links == dydv7ts0u3hym5vdvh7ookh7pxxt1gh 115082 115081 2026-10-20T16:57:44Z DaSupremo 9 Improve article 115082 wikitext text/x-wiki {{Databox}} '''Treacher Collins syndrome''' ('''TCS''') be a [[genetic disorder]] wey be characterized by deformities of de ears, eyes, cheekbones, den chin.<ref name="GHR20122">{{cite web |date=June 2012 |title=Treacher Collins syndrome |url=https://medlineplus.gov/genetics/condition/treacher-collins-syndrome/ |url-status=live |archive-url=https://web.archive.org/web/20200626164632/https://ghr.nlm.nih.gov/condition/treacher-collins-syndrome |archive-date=26 June 2020 |access-date=7 November 2017 |website=Genetics Home Reference |language=en}}</ref> De degree to wich a person be affected fi vary from mild to severe.<ref name="GHR20122" /> Complications fi include breathing problems, vision problems, [[cleft palate]], den [[hearing loss]].<ref name="GHR20122" /> Those affected generally get normal intelligence.<ref name="GHR20122" /> TCS usually be [[autosomal dominant]].<ref name=GHR2012/> More dan half of occurrences be as a result of a new [[mutation]] rather dan inherited.<ref name=GHR2012/> De involved genes fi include ''[[TCOF1]]'', ''[[POLR1C]]'', anaa ''[[POLR1D]]''.<ref name=GHR2012/> Diagnosis generally be based on symptoms den [[radiographs|X-rays]], den potentially confirmation by [[genetic testing]].<ref name=NORD2016>{{cite web|title=Treacher Collins Syndrome|url=https://rarediseases.org/rare-diseases/treacher-collins-syndrome/|website=NORD (National Organization for Rare Disorders)|access-date=7 November 2017|date=2016|archive-date=20 December 2019|archive-url=https://web.archive.org/web/20191220130746/https://rarediseases.org/rare-diseases/treacher-collins-syndrome/|url-status=live}}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] 56mgwpsmeghc0zvuqs4aikdi20kv0rq 115083 115082 2026-10-20T17:03:28Z DaSupremo 9 Improve article 115083 wikitext text/x-wiki {{Databox}} '''Treacher Collins syndrome''' ('''TCS''') be a [[genetic disorder]] wey be characterized by deformities of de ears, eyes, cheekbones, den chin.<ref name="GHR20122">{{cite web |date=June 2012 |title=Treacher Collins syndrome |url=https://medlineplus.gov/genetics/condition/treacher-collins-syndrome/ |url-status=live |archive-url=https://web.archive.org/web/20200626164632/https://ghr.nlm.nih.gov/condition/treacher-collins-syndrome |archive-date=26 June 2020 |access-date=7 November 2017 |website=Genetics Home Reference |language=en}}</ref> De degree to wich a person be affected fi vary from mild to severe.<ref name="GHR20122" /> Complications fi include breathing problems, vision problems, [[cleft palate]], den [[hearing loss]].<ref name="GHR20122" /> Those affected generally get normal intelligence.<ref name="GHR20122" /> TCS usually be [[autosomal dominant]].<ref name="GHR20122" /> More dan half of occurrences be as a result of a new [[mutation]] rather dan inherited.<ref name="GHR20122" /> De involved genes fi include ''[[TCOF1]]'', ''[[POLR1C]]'', anaa ''[[POLR1D]]''.<ref name="GHR20122" /> Diagnosis generally be based on symptoms den [[radiographs|X-rays]], den potentially confirmation by [[genetic testing]].<ref name=NORD2016>{{cite web|title=Treacher Collins Syndrome|url=https://rarediseases.org/rare-diseases/treacher-collins-syndrome/|website=NORD (National Organization for Rare Disorders)|access-date=7 November 2017|date=2016|archive-date=20 December 2019|archive-url=https://web.archive.org/web/20191220130746/https://rarediseases.org/rare-diseases/treacher-collins-syndrome/|url-status=live}}</ref> Treacher Collins syndrome no be curable.<ref name=GARD2015>{{cite web|title=Treacher Collins syndrome|url=https://rarediseases.info.nih.gov/diseases/9124/treacher-collins-syndrome|website=rarediseases.info.nih.gov|access-date=7 November 2017|language=en|date=2015|archive-date=16 August 2019|archive-url=https://web.archive.org/web/20190816051255/https://rarediseases.info.nih.gov/diseases/9124/treacher-collins-syndrome|url-status=live}}</ref> Symptoms fi be managed plus reconstructive surgery, hearing aids, [[speech therapy]], den oda assistive devices.<ref name=GARD2015/> Life expectancy generally be normal.<ref name=GARD2015/> TCS dey occur insyd about one insyd 50,000 people.<ref name="GHR20122" /> Dem name de syndrome after [[Edward Treacher Collins]], an [[England|English]] [[Surgery|surgeon]] den [[ophthalmology|ophthalmologist]], wey describe ein essential traits insyd 1900.<ref name=Pra2014>{{cite book|last1=R|first1=Pramod John|last2=John|first2=Pramod|title=Textbook of Oral Medicine|date=2014|publisher=JP Medical Ltd|isbn=978-93-5090-850-1|page=76|url=https://books.google.com/books?id=SLkiAwAAQBAJ&pg=PA76|access-date=2017-09-17|archive-date=2020-09-12|archive-url=https://web.archive.org/web/20200912103315/https://books.google.com/books?id=SLkiAwAAQBAJ&pg=PA76|url-status=live}}</ref><ref name=Gre2012>{{cite book|last1=Beighton|first1=Greta|title=The Man Behind the Syndrome|date=2012|publisher=Springer Science & Business Media|isbn=978-1-4471-1415-4|page=173|url=https://books.google.com/books?id=-TGgBQAAQBAJ&pg=PA173}}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] scl4opji5pz9bh59q6695fbdvszl64w 115084 115083 2026-10-20T17:06:37Z DaSupremo 9 Improve article 115084 wikitext text/x-wiki {{Databox}} '''Treacher Collins syndrome''' ('''TCS''') be a [[genetic disorder]] wey be characterized by deformities of de ears, eyes, cheekbones, den chin.<ref name="GHR20122">{{cite web |date=June 2012 |title=Treacher Collins syndrome |url=https://medlineplus.gov/genetics/condition/treacher-collins-syndrome/ |url-status=live |archive-url=https://web.archive.org/web/20200626164632/https://ghr.nlm.nih.gov/condition/treacher-collins-syndrome |archive-date=26 June 2020 |access-date=7 November 2017 |website=Genetics Home Reference |language=en}}</ref> De degree to wich a person be affected fi vary from mild to severe.<ref name="GHR20122" /> Complications fi include breathing problems, vision problems, [[cleft palate]], den [[hearing loss]].<ref name="GHR20122" /> Those affected generally get normal intelligence.<ref name="GHR20122" /> TCS usually be [[autosomal dominant]].<ref name="GHR20122" /> More dan half of occurrences be as a result of a new [[mutation]] rather dan inherited.<ref name="GHR20122" /> De involved genes fi include ''[[TCOF1]]'', ''[[POLR1C]]'', anaa ''[[POLR1D]]''.<ref name="GHR20122" /> Diagnosis generally be based on symptoms den [[radiographs|X-rays]], den potentially confirmation by [[genetic testing]].<ref name=NORD2016>{{cite web|title=Treacher Collins Syndrome|url=https://rarediseases.org/rare-diseases/treacher-collins-syndrome/|website=NORD (National Organization for Rare Disorders)|access-date=7 November 2017|date=2016|archive-date=20 December 2019|archive-url=https://web.archive.org/web/20191220130746/https://rarediseases.org/rare-diseases/treacher-collins-syndrome/|url-status=live}}</ref> Treacher Collins syndrome no be curable.<ref name=GARD2015>{{cite web|title=Treacher Collins syndrome|url=https://rarediseases.info.nih.gov/diseases/9124/treacher-collins-syndrome|website=rarediseases.info.nih.gov|access-date=7 November 2017|language=en|date=2015|archive-date=16 August 2019|archive-url=https://web.archive.org/web/20190816051255/https://rarediseases.info.nih.gov/diseases/9124/treacher-collins-syndrome|url-status=live}}</ref> Symptoms fi be managed plus reconstructive surgery, hearing aids, [[speech therapy]], den oda assistive devices.<ref name=GARD2015/> Life expectancy generally be normal.<ref name=GARD2015/> TCS dey occur insyd about one insyd 50,000 people.<ref name="GHR20122" /> Dem name de syndrome after [[Edward Treacher Collins]], an [[England|English]] [[Surgery|surgeon]] den [[ophthalmology|ophthalmologist]], wey describe ein essential traits insyd 1900.<ref name=Pra2014>{{cite book|last1=R|first1=Pramod John|last2=John|first2=Pramod|title=Textbook of Oral Medicine|date=2014|publisher=JP Medical Ltd|isbn=978-93-5090-850-1|page=76|url=https://books.google.com/books?id=SLkiAwAAQBAJ&pg=PA76|access-date=2017-09-17|archive-date=2020-09-12|archive-url=https://web.archive.org/web/20200912103315/https://books.google.com/books?id=SLkiAwAAQBAJ&pg=PA76|url-status=live}}</ref><ref name=Gre2012>{{cite book|last1=Beighton|first1=Greta|title=The Man Behind the Syndrome|date=2012|publisher=Springer Science & Business Media|isbn=978-1-4471-1415-4|page=173|url=https://books.google.com/books?id=-TGgBQAAQBAJ&pg=PA173}}</ref> == References == <references /> == External links == {{Commons}} {{Authority control}} {{DEFAULTSORT:Treacher Collins Syndrome}} [[Category:Genodermatoses]] [[Category:Rare syndromes]] [[Category:Hearing loss plus craniofacial syndromes]] [[Category:Congenital disorders of musculoskeletal system]] [[Category:Autosomal dominant disorders]] [[Category:Nucleus diseases]] [[Category:Connective tissue diseases]] [[Category:Diseases dem name after discoverers]] [[Category:Translated from MDWiki]] gmvxkk7z6mbhbultxzxnike7l7g9srg 14 31102 115085 2026-10-20T17:07:37Z DaSupremo 9 Fresh category 115085 wikitext text/x-wiki phoiac9h4m842xq45sp7s6u21eteeq1 0 31103 115086 2026-10-20T17:11:00Z DaSupremo 9 Created by translating the page [[:mdwiki:Special:Redirect/revision/1501673|Doxylamine]] to:gpe #mdwikicx 115086 wikitext text/x-wiki [[Category:Translated from MDWiki]] r0gf7axtnvt68k0p85plnlehx64o08u 115088 115086 2026-10-20T17:47:47Z DaSupremo 9 Improve article 115088 wikitext text/x-wiki {{Databox}} '''Doxylamine''' be an [[antihistamine]] medication dem use to treat [[insomnia]] den [[allergy|allergies]], and&mdash;in combination plus [[pyridoxine]] ([[vitamin B6|vitamin B₆]])&mdash;to treat [[morning sickness]] insyd [[pregnant]] women. E be available [[over-the-counter]] wey dem dey sell am under such brand names as '''Unisom''', among odas; wey e be used insyd nighttime [[cold medicine]]s (e.g., [[NyQuil]]) den [[pain medication]]s wey dey contain [[paracetamol]] (acetaminophen) anaa [[codeine]] to help plus [[sleep]]. De medication be delivered chemically by de salt doxylamine succinate wey dem dey take am [[oral administration|by mouth]]. Doxylamine den oda [[first-generation antihistamine]]s be de most widely used sleep medications insyd de world.<ref name="SimonsSimons20112">{{cite journal |vauthors=Simons FE, Simons KJ |date=December 2011 |title=Histamine and H1-antihistamines: celebrating a century of progress |journal=The Journal of Allergy and Clinical Immunology |volume=128 |issue=6 |pages=1139–1150.e4 |doi=10.1016/j.jaci.2011.09.005 |pmid=22035879 |doi-access=free}}</ref> Typical [[side effect]]s of doxylamine dey include [[dizziness]], [[drowsiness]], [[grogginess]], den [[dry mouth]], among odas.<ref name="pmid17824496">{{cite journal|vauthors=Neubauer DN|title=The evolution and development of insomnia pharmacotherapies|journal=Journal of Clinical Sleep Medicine|volume=3|issue=5 Suppl|pages=S11–S15|date=August 2007|pmid=17824496|pmc=1978321|doi=10.5664/jcsm.26930}}</ref><ref name="pmid270574162">{{cite journal |vauthors=Culpepper L, Wingertzahn MA |date=2015 |title=Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety |journal=The Primary Care Companion for CNS Disorders |volume=17 |issue=6 |doi=10.4088/PCC.15r01798 |pmc=4805417 |pmid=27057416}}</ref> == References == [[Category:Translated from MDWiki]] <references /> == External links == 39xxngj5kiebn2xlz35ri5bb1h7v9ap 115089 115088 2026-10-20T23:25:46Z DaSupremo 9 Improve article 115089 wikitext text/x-wiki {{Databox}} '''Doxylamine''' be an [[antihistamine]] medication dem use to treat [[insomnia]] den [[allergy|allergies]], and&mdash;in combination plus [[pyridoxine]] ([[vitamin B6|vitamin B₆]])&mdash;to treat [[morning sickness]] insyd [[pregnant]] women. E be available [[over-the-counter]] wey dem dey sell am under such brand names as '''Unisom''', among odas; wey e be used insyd nighttime [[cold medicine]]s (e.g., [[NyQuil]]) den [[pain medication]]s wey dey contain [[paracetamol]] (acetaminophen) anaa [[codeine]] to help plus [[sleep]]. De medication be delivered chemically by de salt doxylamine succinate wey dem dey take am [[oral administration|by mouth]]. Doxylamine den oda [[first-generation antihistamine]]s be de most widely used sleep medications insyd de world.<ref name="SimonsSimons20112">{{cite journal |vauthors=Simons FE, Simons KJ |date=December 2011 |title=Histamine and H1-antihistamines: celebrating a century of progress |journal=The Journal of Allergy and Clinical Immunology |volume=128 |issue=6 |pages=1139–1150.e4 |doi=10.1016/j.jaci.2011.09.005 |pmid=22035879 |doi-access=free}}</ref> Typical [[side effect]]s of doxylamine dey include [[dizziness]], [[drowsiness]], [[grogginess]], den [[dry mouth]], among odas.<ref name="pmid17824496">{{cite journal|vauthors=Neubauer DN|title=The evolution and development of insomnia pharmacotherapies|journal=Journal of Clinical Sleep Medicine|volume=3|issue=5 Suppl|pages=S11–S15|date=August 2007|pmid=17824496|pmc=1978321|doi=10.5664/jcsm.26930}}</ref><ref name="pmid270574162">{{cite journal |vauthors=Culpepper L, Wingertzahn MA |date=2015 |title=Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety |journal=The Primary Care Companion for CNS Disorders |volume=17 |issue=6 |doi=10.4088/PCC.15r01798 |pmc=4805417 |pmid=27057416}}</ref> As an antihistamine, doxylamine be an [[inverse agonist]] of de [[histamine]] [[H1 receptor|H₁ receptor]]. As a first-generation antihistamine, e typically dey cross de [[blood–brain barrier]] into de [[brain]], thereby producing a suite of [[sedative]] den [[hypnotic]] effects wey be mediated by de [[central nervous system]]. == References == <references /> == External links == [[Category:Translated from MDWiki]] dyaqaqb88evr95j2e13mdepuqucu31k 115090 115089 2026-10-20T23:35:46Z DaSupremo 9 Improve article 115090 wikitext text/x-wiki {{Databox}} '''Doxylamine''' be an [[antihistamine]] medication dem use to treat [[insomnia]] den [[allergy|allergies]], and&mdash;in combination plus [[pyridoxine]] ([[vitamin B6|vitamin B₆]])&mdash;to treat [[morning sickness]] insyd [[pregnant]] women. E be available [[over-the-counter]] wey dem dey sell am under such brand names as '''Unisom''', among odas; wey e be used insyd nighttime [[cold medicine]]s (e.g., [[NyQuil]]) den [[pain medication]]s wey dey contain [[paracetamol]] (acetaminophen) anaa [[codeine]] to help plus [[sleep]]. De medication be delivered chemically by de salt doxylamine succinate wey dem dey take am [[oral administration|by mouth]]. Doxylamine den oda [[first-generation antihistamine]]s be de most widely used sleep medications insyd de world.<ref name="SimonsSimons20112">{{cite journal |vauthors=Simons FE, Simons KJ |date=December 2011 |title=Histamine and H1-antihistamines: celebrating a century of progress |journal=The Journal of Allergy and Clinical Immunology |volume=128 |issue=6 |pages=1139–1150.e4 |doi=10.1016/j.jaci.2011.09.005 |pmid=22035879 |doi-access=free}}</ref> Typical [[side effect]]s of doxylamine dey include [[dizziness]], [[drowsiness]], [[grogginess]], den [[dry mouth]], among odas.<ref name="pmid17824496">{{cite journal|vauthors=Neubauer DN|title=The evolution and development of insomnia pharmacotherapies|journal=Journal of Clinical Sleep Medicine|volume=3|issue=5 Suppl|pages=S11–S15|date=August 2007|pmid=17824496|pmc=1978321|doi=10.5664/jcsm.26930}}</ref><ref name="pmid270574162">{{cite journal |vauthors=Culpepper L, Wingertzahn MA |date=2015 |title=Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety |journal=The Primary Care Companion for CNS Disorders |volume=17 |issue=6 |doi=10.4088/PCC.15r01798 |pmc=4805417 |pmid=27057416}}</ref> As an antihistamine, doxylamine be an [[inverse agonist]] of de [[histamine]] [[H1 receptor|H₁ receptor]]. As a first-generation antihistamine, e typically dey cross de [[blood–brain barrier]] into de [[brain]], thereby producing a suite of [[sedative]] den [[hypnotic]] effects wey be mediated by de [[central nervous system]]. Doxylamine sanso be a potent [[anticholinergic]], wey dey mean say e dey [[deliriant|cause delirium]] at high doses (i.e., at much higher doses dan recommended).<ref>{{cite web|url=https://psychonautwiki.org/wiki/Doxylamine|title=Doxylamine - PsychonautWiki|access-date=12 July 2023|archive-date=12 July 2023|archive-url=https://web.archive.org/web/20230712170916/https://psychonautwiki.org/wiki/Doxylamine|url-status=dead}}</ref> Specifically, e be an [[receptor antagonist|antagonist]] of de [[muscarinic acetylcholine receptor]]s [[muscarinic acetylcholine receptor M1|M₁]] thru [[muscarinic acetylcholine receptor M5|M₅]]. Dese sedative den deliriant effects have insyd sam cases lead to de drug being used recreationally. Na dem first describe doxylamine insyd 1948 anaa 1949.<ref name=Fis2006>{{cite book|vauthors=Fischer J, Ganellin CR|title=Analogue-based Drug Discovery|date=2006|publisher=John Wiley & Sons|isbn=9783527607495|page=546|url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA546}}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] 1gzdnzb4u5feg12iw3pfsiwnygzm237 115091 115090 2026-10-20T23:42:28Z DaSupremo 9 Improve article 115091 wikitext text/x-wiki {{Databox}} '''Doxylamine''' be an [[antihistamine]] medication dem use to treat [[insomnia]] den [[allergy|allergies]], and&mdash;in combination plus [[pyridoxine]] ([[vitamin B6|vitamin B₆]])&mdash;to treat [[morning sickness]] insyd [[pregnant]] women. E be available [[over-the-counter]] wey dem dey sell am under such brand names as '''Unisom''', among odas; wey e be used insyd nighttime [[cold medicine]]s (e.g., [[NyQuil]]) den [[pain medication]]s wey dey contain [[paracetamol]] (acetaminophen) anaa [[codeine]] to help plus [[sleep]]. De medication be delivered chemically by de salt doxylamine succinate wey dem dey take am [[oral administration|by mouth]]. Doxylamine den oda [[first-generation antihistamine]]s be de most widely used sleep medications insyd de world.<ref name="SimonsSimons20112">{{cite journal |vauthors=Simons FE, Simons KJ |date=December 2011 |title=Histamine and H1-antihistamines: celebrating a century of progress |journal=The Journal of Allergy and Clinical Immunology |volume=128 |issue=6 |pages=1139–1150.e4 |doi=10.1016/j.jaci.2011.09.005 |pmid=22035879 |doi-access=free}}</ref> Typical [[side effect]]s of doxylamine dey include [[dizziness]], [[drowsiness]], [[grogginess]], den [[dry mouth]], among odas.<ref name="pmid17824496">{{cite journal|vauthors=Neubauer DN|title=The evolution and development of insomnia pharmacotherapies|journal=Journal of Clinical Sleep Medicine|volume=3|issue=5 Suppl|pages=S11–S15|date=August 2007|pmid=17824496|pmc=1978321|doi=10.5664/jcsm.26930}}</ref><ref name="pmid270574162">{{cite journal |vauthors=Culpepper L, Wingertzahn MA |date=2015 |title=Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety |journal=The Primary Care Companion for CNS Disorders |volume=17 |issue=6 |doi=10.4088/PCC.15r01798 |pmc=4805417 |pmid=27057416}}</ref> As an antihistamine, doxylamine be an [[inverse agonist]] of de [[histamine]] [[H1 receptor|H₁ receptor]]. As a first-generation antihistamine, e typically dey cross de [[blood–brain barrier]] into de [[brain]], thereby producing a suite of [[sedative]] den [[hypnotic]] effects wey be mediated by de [[central nervous system]]. Doxylamine sanso be a potent [[anticholinergic]], wey dey mean say e dey [[deliriant|cause delirium]] at high doses (i.e., at much higher doses dan recommended).<ref>{{cite web|url=https://psychonautwiki.org/wiki/Doxylamine|title=Doxylamine - PsychonautWiki|access-date=12 July 2023|archive-date=12 July 2023|archive-url=https://web.archive.org/web/20230712170916/https://psychonautwiki.org/wiki/Doxylamine|url-status=dead}}</ref> Specifically, e be an [[receptor antagonist|antagonist]] of de [[muscarinic acetylcholine receptor]]s [[muscarinic acetylcholine receptor M1|M₁]] thru [[muscarinic acetylcholine receptor M5|M₅]]. Dese sedative den deliriant effects have insyd sam cases lead to de drug being used recreationally. Na dem first describe doxylamine insyd 1948 anaa 1949.<ref name=Fis2006>{{cite book|vauthors=Fischer J, Ganellin CR|title=Analogue-based Drug Discovery|date=2006|publisher=John Wiley & Sons|isbn=9783527607495|page=546|url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA546}}</ref> == References == <references /> == External links == {{Commons}} [[Category:2-Pyridyl compounds]] [[Category:Antiemetics]] [[Category:Antihistamines]] [[Category:Deliriants]] [[Category:Dimethylamino compounds]] [[Category:Ethanolamines]] [[Category:Ethers]] [[Category:H1 receptor antagonists]] [[Category:Hypnotics]] [[Category:M1 receptor antagonists]] [[Category:M3 receptor antagonists]] [[Category:M4 receptor antagonists]] [[Category:M5 receptor antagonists]] [[Category:Over-the-counter drugs insyd de United States]] [[Category:Sedatives]] [[Category:Translated from MDWiki]] mfgyay0zm3ymyb2bbq45holxtkrw2cx 14 31104 115092 2026-10-20T23:43:50Z DaSupremo 9 Fresh category 115092 wikitext text/x-wiki phoiac9h4m842xq45sp7s6u21eteeq1 14 31105 115093 2026-10-20T23:44:06Z DaSupremo 9 Fresh category 115093 wikitext text/x-wiki phoiac9h4m842xq45sp7s6u21eteeq1