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https://test.wikidata.org/wiki/Wikidata:Main_Page
MediaWiki 1.47.0-wmf.3
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Q245486
0
340142
770256
2026-05-24T22:22:34Z
Sallemi Yosra
9075
/* wbeditentity-create:2|en */ Compositeur, classe des compositeurs de musique classique
770256
wikibase-item
application/json
{"type":"item","id":"Q245486","labels":{"fr":{"language":"fr","value":"Compositeur"}},"descriptions":{"fr":{"language":"fr","value":"classe des compositeurs de musique classique"}},"aliases":[],"claims":[],"sitelinks":[]}
kw85lzusb9wzjj91kozede640b05rmt
770257
770256
2026-05-24T22:24:52Z
Sallemi Yosra
9075
/* wbsetclaim-create:2||1 */ [[Property:P82]]: [[Q210391]]
770257
wikibase-item
application/json
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Q245487
0
340143
770258
2026-05-24T22:25:47Z
Sallemi Yosra
9075
/* wbeditentity-create:2|en */ Œuvre musicale, classe des œuvres de musique classique
770258
wikibase-item
application/json
{"type":"item","id":"Q245487","labels":{"fr":{"language":"fr","value":"\u0152uvre musicale"}},"descriptions":{"fr":{"language":"fr","value":"classe des \u0153uvres de musique classique"}},"aliases":[],"claims":[],"sitelinks":[]}
ew12g6hnxz3mg6x2yw5gt4chfhaxlrz
770259
770258
2026-05-24T22:26:05Z
Sallemi Yosra
9075
/* wbsetclaim-create:2||1 */ [[Property:P82]]: [[Q210391]]
770259
wikibase-item
application/json
{"type":"item","id":"Q245487","labels":{"fr":{"language":"fr","value":"\u0152uvre musicale"}},"descriptions":{"fr":{"language":"fr","value":"classe des \u0153uvres de musique classique"}},"aliases":[],"claims":{"P82":[{"mainsnak":{"snaktype":"value","property":"P82","hash":"f670dbedeea2fd17fb781f74533e4ca8ed527aeb","datavalue":{"value":{"entity-type":"item","numeric-id":210391,"id":"Q210391"},"type":"wikibase-entityid"}},"type":"statement","id":"Q245487$eb2ac3f7-40f8-6444-620c-4e6c8b575659","rank":"normal"}]},"sitelinks":[]}
f5109i78ltxafrnc5hjiy3blyivo9p0
Q245488
0
340144
770260
2026-05-24T22:27:07Z
Sallemi Yosra
9075
/* wbeditentity-create:2|en */ Symphonie, classe des symphonies
770260
wikibase-item
application/json
{"type":"item","id":"Q245488","labels":{"fr":{"language":"fr","value":"Symphonie"}},"descriptions":{"fr":{"language":"fr","value":"classe des symphonies"}},"aliases":[],"claims":[],"sitelinks":[]}
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770261
770260
2026-05-24T22:27:21Z
Sallemi Yosra
9075
/* wbsetclaim-create:2||1 */ [[Property:P82]]: [[Q210391]]
770261
wikibase-item
application/json
{"type":"item","id":"Q245488","labels":{"fr":{"language":"fr","value":"Symphonie"}},"descriptions":{"fr":{"language":"fr","value":"classe des symphonies"}},"aliases":[],"claims":{"P82":[{"mainsnak":{"snaktype":"value","property":"P82","hash":"f670dbedeea2fd17fb781f74533e4ca8ed527aeb","datavalue":{"value":{"entity-type":"item","numeric-id":210391,"id":"Q210391"},"type":"wikibase-entityid"}},"type":"statement","id":"Q245488$e4b5d94a-4aa0-87cb-6561-9220665c55a6","rank":"normal"}]},"sitelinks":[]}
rc0sybdtppj5qrzbi54ptocslcqd4og
Q245489
0
340145
770262
2026-05-24T22:29:28Z
Sallemi Yosra
9075
/* wbeditentity-create:2|en */ Compositeur test A, compositeur de test
770262
wikibase-item
application/json
{"type":"item","id":"Q245489","labels":{"fr":{"language":"fr","value":"Compositeur test A"}},"descriptions":{"fr":{"language":"fr","value":"compositeur de test"}},"aliases":[],"claims":[],"sitelinks":[]}
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770263
770262
2026-05-24T22:29:49Z
Sallemi Yosra
9075
/* wbsetclaim-create:2||1 */ [[Property:P82]]: [[Q245486]]
770263
wikibase-item
application/json
{"type":"item","id":"Q245489","labels":{"fr":{"language":"fr","value":"Compositeur test A"}},"descriptions":{"fr":{"language":"fr","value":"compositeur de test"}},"aliases":[],"claims":{"P82":[{"mainsnak":{"snaktype":"value","property":"P82","hash":"1e57686e57228425da86884b3791bbcee7f21363","datavalue":{"value":{"entity-type":"item","numeric-id":245486,"id":"Q245486"},"type":"wikibase-entityid"}},"type":"statement","id":"Q245489$080e0aef-4538-7087-e603-c6bfcc24d909","rank":"normal"}]},"sitelinks":[]}
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Q245490
0
340146
770264
2026-05-24T22:30:26Z
Sallemi Yosra
9075
/* wbeditentity-create:2|en */ Symphonie test 1, symphonie de test
770264
wikibase-item
application/json
{"type":"item","id":"Q245490","labels":{"fr":{"language":"fr","value":"Symphonie test 1"}},"descriptions":{"fr":{"language":"fr","value":"symphonie de test"}},"aliases":[],"claims":[],"sitelinks":[]}
f3qt7e8zg4vsmpw1vyj678njzyl4nba
770265
770264
2026-05-24T22:30:40Z
Sallemi Yosra
9075
/* wbsetclaim-create:2||1 */ [[Property:P82]]: [[Q230567]]
770265
wikibase-item
application/json
{"type":"item","id":"Q245490","labels":{"fr":{"language":"fr","value":"Symphonie test 1"}},"descriptions":{"fr":{"language":"fr","value":"symphonie de test"}},"aliases":[],"claims":{"P82":[{"mainsnak":{"snaktype":"value","property":"P82","hash":"01e4e48e0472827630dd1609621c9d05fdf37b01","datavalue":{"value":{"entity-type":"item","numeric-id":230567,"id":"Q230567"},"type":"wikibase-entityid"}},"type":"statement","id":"Q245490$9424157a-4fad-4b96-1e5e-d382ca8fb216","rank":"normal"}]},"sitelinks":[]}
mvsnor7doifa0oop5wjb4fpjg4a0h5j
770266
770265
2026-05-24T22:35:36Z
Sallemi Yosra
9075
/* wbsetclaim-update:2||1 */ [[Property:P82]]: [[Q245488]]
770266
wikibase-item
application/json
{"type":"item","id":"Q245490","labels":{"fr":{"language":"fr","value":"Symphonie test 1"}},"descriptions":{"fr":{"language":"fr","value":"symphonie de test"}},"aliases":[],"claims":{"P82":[{"mainsnak":{"snaktype":"value","property":"P82","hash":"a8b722717c9cc19de67e9c18f45ad694564ee414","datavalue":{"value":{"entity-type":"item","numeric-id":245488,"id":"Q245488"},"type":"wikibase-entityid"}},"type":"statement","id":"Q245490$9424157a-4fad-4b96-1e5e-d382ca8fb216","rank":"normal"}]},"sitelinks":[]}
84o6ljk6mfbvtvaefrl0nvz3gifojsx
770267
770266
2026-05-24T22:36:10Z
Sallemi Yosra
9075
/* wbsetclaim-create:2||1 */ [[Property:P96555]]: Compositeur test A
770267
wikibase-item
application/json
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pvt667ju0djrzg24ye4gk1vsgqp0dku
User:Mr. Ibrahem/test
2
340147
770268
2026-05-24T23:20:50Z
Mr. Ibrahem
1913
Created page with "{{#unlinkedwikibase:id=Q27155409}} {{Short description|Monoclonal antibody}} {{Infobox drug | image = Emicizumab.png | alt = <!-- Monoclonal antibody data --> | type = mab | mab_type = mab | source = zu | target = Activated [[factor IX]], [[factor X]] <!-- Names --> | pronounce = | tradename = Hemlibra | synonyms = ACE910, RG6013, emicizumab-kxwh | IUPAC_name = <!--..."
770268
wikitext
text/x-wiki
{{#unlinkedwikibase:id=Q27155409}}
{{Short description|Monoclonal antibody}}
{{Infobox drug
| image = Emicizumab.png
| alt =
<!-- Monoclonal antibody data -->
| type = mab
| mab_type = mab
| source = zu
| target = Activated [[factor IX]], [[factor X]]
<!-- Names -->
| pronounce =
| tradename = Hemlibra
| synonyms = ACE910, RG6013, emicizumab-kxwh
| IUPAC_name =
<!-- Clinical data -->
| class =
| uses = <!-- primary uses -->
| side_effects = <!-- common side effects and notable side effects -->
| interactions = <!-- notable interactions -->
| pregnancy_AU = B2
| pregnancy_AU_comment= <ref name="Hemlibra PI" />
| pregnancy_category=
| breastfeeding =
| routes_of_administration= [[Subcutaneous injection|Subcutaneous]]
| onset =
| duration_of_action=
| defined_daily_dose=
| typical_dose =
<!-- External links -->
| Drugs.com = {{drugs.com|monograph|emicizumab-kxwh}}
| MedlinePlus =
<!-- Legal data -->
| legal_AU = S4
| legal_AU_comment = <ref name="Hemlibra PI">{{cite web |url=https://www.guildlink.com.au/gc/ws/ro/pi.cfm?product=rophemli10218 |title=AUSTRALIAN PRODUCT INFORMATION – Hemlibra (Emicizumab) |archive-url=https://web.archive.org/web/20230515185854/https://www.guildlink.com.au/gc/ws/ro/pi.cfm?product=rophemli10218 |archive-date=15 May 2023 |access-date=8 January 2023}}</ref>
| legal_CA = Rx-only
| legal_CA_comment = / Schedule D<ref>{{cite web | title=Summary Basis of Decision (SBD) for Hemlibra | website=[[Health Canada]] | date=23 October 2014 | url=https://hpr-rps.hres.ca/reg-content/summary-basis-decision-detailTwo.php?linkID=SBD00411&lang=en | access-date=29 May 2022}}</ref>
| legal_EU = Rx-only
| legal_NZ = <!--Class A, B, C -->
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV-->
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM -->
| legal_US = Rx-only
| legal_status = Rx-only
| DailyMedID = Emicizumab
<!-- Pharmacokinetic data -->
| bioavailability =
| protein_bound =
| metabolism =
| metabolites =
| elimination_half-life=
| excretion =
<!-- Chemical and physical data -->
| C= 6434 | H= 9940 | N= 1724 | O= 2047 | S= 45
}}
<!-- Definition and medical uses -->
'''Emicizumab''', sold under the brand name '''Hemlibra''', is a medication used to treat [[haemophilia A]], including in those resistant to other treatments.<ref name=PI2025/> It is used in moderate to severe disease, and occationally mild disease.<ref name=Al2024>{{cite journal |last1=Alcedo Andrade |first1=PE |last2=Mannucci |first2=PM |last3=Kessler |first3=CM |title=Emicizumab: the hemophilia A game-changer. |journal=Haematologica |date=1 May 2024 |volume=109 |issue=5 |pages=1334-1347 |doi=10.3324/haematol.2022.282099 |pmid=37916312}}</ref><ref name=AHFS2025>{{cite web |title=Emicizumab-kxwh Monograph for Professionals |url=https://www.drugs.com/monograph/emicizumab-kxwh.html |website=Drugs.com |accessdate=3 October 2025 |language=en}}</ref> Benefits include that it is give subcutaneous and requires less frequent injections.<ref>{{cite journal | vauthors = Grabowska K, Grzelak M, Zhao LY, Płuciennik E, Pasieka Z, Kciuk M, Gielecińska A, Smakosz AK, Kałuzińska-Kołat Ż, Kołat D | title = Emicizumab as a Promising Form of Therapy for Type A Hemophilia - A Review of Current Knowledge from Clinical Trials | journal = Current Protein & Peptide Science | volume = 25 | pages = 719–737 | date = May 2024 | issue = 9 | pmid = 38797909 | doi = 10.2174/0113892037294674240509094418 }}</ref>
<!-- Side effects and mechanism -->
Common side effects include reactions at the side of injection, headache, and joint pain.<ref name=PI2025/> Less commonly [[antibodies]] may develop against the medication, or blood clots may form.<ref name=PI2025/><ref name=EMA2025/> It may react with [[activated prothrombin complex concentrate]].<ref name=PI2025/> It is a [[bispecific monoclonal antibody]] that helps the [[blood clot]] by bringing [[factor IXa]] and [[factor X]] together.<ref name=PI2025/><ref name=EMA2025>{{cite web |title=Hemlibra |url=https://www.ema.europa.eu/en/medicines/human/EPAR/hemlibra |website=www.ema.europa.eu |publisher=European Medicines Agency (EMA) |accessdate=3 October 2025 |language=en |date=23 August 2018}}</ref>
<!-- History and culture -->
Emicizumab was approved for medical use in the United States in 2017 and Europe in 2018.<ref name=PI2025>{{cite web |title=DailyMed - HEMLIBRA- emicizumab injection, solution |url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2483adba-fab6-4d1b-96c5-c195577ed071 |website=dailymed.nlm.nih.gov |accessdate=3 October 2025}}</ref><ref name=EMA2025/> In 2019 the cost for a typical adult in Canada was 670,000 CAD per year.<ref>{{cite news |title=Why one Nova Scotia boy is being treated with drugs that cost $6-million a year despite a better, cheaper alternative |url=https://www.theglobeandmail.com/canada/article-why-one-nova-scotia-boy-is-being-treated-with-6-million-a-year-drugs/ |accessdate=3 October 2025 |work=The Globe and Mail |date=5 May 2019 |language=en-CA}}</ref> In the United States this amount is about 480,000 USD per year as of 2025.<ref>{{cite web |title=Hemlibra Prices, Coupons, Copay Cards & Patient Assistance |url=https://www.drugs.com/price-guide/hemlibra |website=Drugs.com |accessdate=3 October 2025 |language=en}}</ref>
==Medical uses==
It is used to treat [[haemophilia A]] including in those with [[factor VIII]] inhibitors.<ref name=PI2025/> It is used preventatively to prevent bleeding.<ref name=AHFS2025/>
===Dosage===
It is started at a dose of 3 mg/kg once a week for four weeks followed by further doses every one to four weeks.<ref name=PI2025/> It is taken long term.<ref name=EMA2025/>
==Side effects==
The most common side effects are (incidence ≥10%) [[injection site reaction]]s, [[headache]], and [[arthralgia]].<ref>{{Drugs.com|pro|hemlibra}}</ref>
==Mechanism of action==
Emicizumab binds to both the activated [[coagulation factor IX]] and to [[factor X]], mediating the activation of the latter. This is normally the function of [[coagulation factor VIII]], which is missing in haemophilia A patients.<ref name="Spreitzer" /><ref>{{cite journal | vauthors = Shima M, Hanabusa H, Taki M, Matsushita T, Sato T, Fukutake K, Fukazawa N, Yoneyama K, Yoshida H, Nogami K | title = Factor VIII-Mimetic Function of Humanized Bispecific Antibody in Hemophilia A | journal = The New England Journal of Medicine | volume = 374 | issue = 21 | pages = 2044–53 | date = May 2016 | pmid = 27223146 | doi = 10.1056/NEJMoa1511769 | doi-access =free }}</ref>
==History==
It was developed by [[Genentech]] and [[Chugai]] (both organizations are subsidiaries of [[Hoffmann-La Roche]]).<ref name="Spreitzer">{{cite journal | vauthors = Spreitzer H | date = 4 July 2016 | title = Neue Wirkstoffe - Emicizumab | journal = Österreichische Apothekerzeitung | issue = 14/2016 | language = German }}</ref> The U.S. [[Food and Drug Administration]] (FDA) considers it to be a [[first-in-class medication]].<ref>{{cite report | title=New Drug Therapy Approvals 2017 | website=U.S. [[Food and Drug Administration]] (FDA) | date=January 2018 | url=https://www.fda.gov/media/110526/download | archive-url=https://web.archive.org/web/20190914090907/https://www.fda.gov/media/110526/download | url-status=dead | archive-date=14 September 2019 | format=PDF | access-date=16 September 2020}}</ref>
== References ==
{{Reflist}}
== External links ==
{{drug resources
<!--Identifiers-->
| CAS_number = 1610943-06-0
| PubChem =
| DrugBank = DB13923
| ChemSpiderID = none
| UNII = 7NL2E3F6K3
| KEGG = D10821
| KEGG_Ref = {{keggcite|correct|kegg}}
| ATC_prefix = B02
| ATC_suffix = BX06
}}
{{Antihemorrhagics}}
{{Monoclonals for bone, musculoskeletal, circulatory, and neurologic systems}}
{{Authority control}}
[[Category:Haemophilia drugs]]
[[Category:Drugs developed by Hoffmann-La Roche]]
[[Category:Drugs developed by Genentech]]
[[Category:Monoclonal antibodies]]
lzr5octro4skjtn5a4xai97jbcxpklb
770269
770268
2026-05-24T23:25:00Z
Mr. Ibrahem
1913
Replaced content with "."
770269
wikitext
text/x-wiki
.
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Q245491
0
340148
770270
2026-05-25T08:12:42Z
WolfgangFahl
6717
/* wbeditentity-create-item:0| */
770270
wikibase-item
application/json
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s2538yi0v99lne03jtnrwydjrxnkfqs
Q245492
0
340149
770271
2026-05-25T08:12:44Z
WolfgangFahl
6717
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770271
wikibase-item
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c53acffg7qd4wvttua05bwluq211odc
770272
770271
2026-05-25T08:12:44Z
WolfgangFahl
6717
/* wbsetclaim-create:1||1 */ [[Property:P96927]]: 2022
770272
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