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Many prion protein transformations are characterized by increased ß-sheet content (depicted by green arrows). In this picture, the left image is the normal PRNP protein. After isomerization, note that the right-side image contains considerably more ß-sheet content. These ß-sheets often constitute an electric dipole and can lead to amyloid aggregation.
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http://en.wikipedia.org/wiki/Image:Prion.gif
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This image is copyrighted. The copyright holder has irrevocably released all rights to it, allowing it to be freely reproduced, distributed, transmitted, used, modified, built upon, or otherwise exploited in any way by anyone for any purpose, commercial or non-commercial, with or without attribution of the author.
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